Predictive value of D‐dimer/albumin ratio and fibrinogen/albumin ratio for in‐hospital mortality in patients with COVID‐19

Abstract

Introduction: Due to the high mortality of coronavirus disease 2019 (COVID-19), there are difficulties in the managing emergency department. We investigated whether the D-dimer/albumin ratio (DAR) and fibrinogen/albumin ratio (FAR) predict mortality in the COVID-19 patients.Methods: A total of 717 COVID-19 patients who were brought to the emergency department from March to October 2020 were included in the study. Levels of D-dimer, fibrinogen and albumin, as well as DAR, FAR, age, gender and in-hospital mortality status of the patients, were recorded. The patients were grouped by in-hospital mortality. Statistical comparison was conducted between the groups.Results: Of the patients included in the study, 371 (51.7%) were male, and their median age was 64 years (50-74). There was in-hospital mortality in 126 (17.6%) patients.The area under the curve (AUC) and odds ratio values obtained by DAR to predict inhospital mortality were higher than the values obtained by the all other parameters

Fibrinogen and Atherosclerotic Cardiovascular Diseases—Review of the Literature and Clinical Studies

“…Perhaps the reduction in fibrinogen concentration by statins is one of the elements of their beneficial influence on improving the prognosis of COVID-19 [ 107 , 108 ]. Moreover, the results of numerous clinical studies indicate that the assessment of fibrinogen concentration may be a useful indicator in the assessment of the prognosis of patients with COVID-19 [ 109 , 110 , 111 , 112 ].…”

Prognostic value of albumin‐related ratios in HBV‐associated decompensated cirrhosis

“…Meanwhile, recent studies showed that elevated plasma D‐dimer can predict poor prognosis in patients with liver diseases. 32 , 33 , 34 Küçükceran et al 15 found that DAR, as the ratio of D‐dimer to albumin, can serve as a valuable predictor for mortality in COVID‐19 patients. 15 However, the present results showed that DAR was similar between non‐survivors and survivors among HBV‐DeCi patients.…”

“…Decreased albumin is a common complication in cirrhotic patients that can lead to ascites and hepatic encephalopathy, and even a tendency toward spontaneous bacterial peritonitis, and has a negative impact on prognosis. 10 , 11 Recently, the clinical usefulness of albumin‐related biomarkers available from routine testing has been reported in various diseases, including liver diseases, such as C‐reactive protein‐to‐albumin ratio (CAR), 12 , 13 , 14 D‐dimer‐to‐albumin ratio (DAR), 15 prothrombin time‐international normalized ratio‐to‐albumin ratio (PTAR), 16 , 17 , 18 neutrophil count‐to‐albumin (NAR), 19 , 20 , 21 and blood urea nitrogen‐to‐albumin ratio (BAR). 22 , 23 , 24 , 25 However, no studies have investigated the differences in prognostic value of these albumin‐related ratios in HBV‐DeCi patients.…”

Age-Associated Increase in Thrombogenicity and Its Correlation with von Willebrand Factor

“…Multiple hematological abnormalities are observed in COVID-19 patients including elevated levels of fibrinogen and D-Dimer in critically ill patients [ 127 , 136 , 137 ]. However, hematological analyses of these patients have also found that VWF levels and activities were elevated five to six folds beyond the upper normal limit [ 128 , 138 ].…”