Predictive Value of Decreasing Antithrombin III in Deep-Vein Thrombosis

Andreasen, Thorkild

doi:10.1055/s-0038-1650103

Cited by 3 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The difference between the transfusion volumes was not significant by the 'W' ranking test other hand, some types of liver disease with markedly lowered AT levels are not asso ciated with thrombophilia [6,39], the pre sumed reason being the simultaneous deple tion of procoagulants. A relationship be tween a surgery-induced decrease of AT lev els and postoperative thrombosis has been assumed [36], but other authors consider it to be equivocal [5,37], Like other investigators addressing this question [36], we did not use objective (and invasive) methods to detect 'silent' instances of such complications, so the total of 16 cases in our former study of 372 patients [23] rep resents those episodes which had a discern ible effect on the clinical course. There were 3 cases of myocardial infarction, 1 pulmo nary embolism, 1 superficial venous throm bosis, as well as 4 venous and 7 arterial reoc clusions.…”

Section: Clinical Incidence Of Thromboembolic Complicationsmentioning

confidence: 99%

Antithrombin III and Related Parameters in Surgical Patients Receiving Blood Components

Lundsgaard-Hansen¹,

Ehrengruber²,

Frei³

et al. 1984

Vox Sanguinis

View full text Add to dashboard Cite

We examined the intra- and postoperative behavior of antithrombin III (AT), factor V, VIII, and fibrinogen in 27 elective surgical patients without evidence of disseminated intravascular coagulation (DIC) and treated according to the concept of blood component therapy inaugurated at our hospital in 1975. The intraoperative depletions of AT and fibrinogen were proportional to the transfusion volumes and correlated significantly. AT, fibrinogen, and especially factor V and VIII were significantly mobilized during surgery. A greater intraoperative depletion of AT was significantly associated with a faster recovery during the first 24 postoperative h. The AT activity was virtually stable over a period of 4 weeks in CPD-adenine red cell concentrates ; fresh frozen plasma and whole blood are thus not essential as a source of AT. The application of our concept did not increase the frequency of thromboembolic complications, despite the fact that the intraoperative AT values fell below the presumed ‘critical’ level of 60-70% in some patients. The probable reasons are the brief duration of such levels, the simultaneous depletion of coagulation-promoting plasma constituents (e.g. fibrinogen), and the use of antithrombotic prophylaxis. Our results suggest no reasons for a routine use of fresh frozen plasma in patients with a loss and replacement of less than about 75% of their blood volume.

show abstract

Section: Clinical Incidence Of Thromboembolic Complicationsmentioning

confidence: 99%

Antithrombin III and Related Parameters in Surgical Patients Receiving Blood Components

Lundsgaard-Hansen¹,

Ehrengruber²,

Frei³

et al. 1984

Vox Sanguinis

View full text Add to dashboard Cite

show abstract

“…The original concept comprised 5 treatment steps designed to safeguard the 'critical levels' of blood volume, hematocrit, total serum protein, plasmatic coagulation factors, and the platelets of the recipient [22]. In percent of his blood volume, losses are replaced as follows: (1) 0-20°/0: plasma substitute (in our hospital, 4% gelatin); (2) 20-50%: red cell concentrates (RCC) with 70% hematocrit, plus plasma substitute; (3) 5O-9O0/o: RCC plus 4-5% albumin; (4) 90-145%: depending on availability, either fresh whole blood or RCC plus fresh frozen plasma (FFP); ( 5 ) from the last year prior to the introduction of this system with those of 175 cases from the first year thereafter [23]. All ofthese patients received blood during major thoracic or vascular surgery under general anesthesia.…”

Section: Introductionmentioning

confidence: 99%

Antithrombin III and Related Parameters in Surgical Patients Receiving Blood Components

et al. 1984

View full text Add to dashboard Cite

We examined the intra- and postoperative behavior of antithrombin III (AT), factor V, VIII, and fibrinogen in 27 elective surgical patients without evidence of disseminated intravascular coagulation (DIC) and treated according to the concept of blood component therapy inaugurated at our hospital in 1975. The intraoperative depletions of AT and fibrinogen were proportional to the transfusion volumes and correlated significantly. AT, fibrinogen, and especially factor V and VIII were significantly mobilized during surgery. A greater intraoperative depletion of AT was significantly associated with a faster recovery during the first 24 postoperative h. The AT activity was virtually stable over a period of 4 weeks in CPD-adenine red cell concentrates; fresh frozen plasma and whole blood are thus not essential as a source of AT. The application of our concept did not increase the frequency of thromboembolic complications, despite the fact that the intraoperative AT values fell below the presumed 'critical' level of 60-70% in some patients. The probable reasons are the brief duration of such levels, the simultaneous depletion of coagulation-promoting plasma constituents (e.g. fibrinogen), and the use of antithrombotic prophylaxis. Our results suggest no reasons for a routine use of fresh frozen plasma in patients with a loss and replacement of less than about 75% of their blood volume.

show abstract

Antithrombin III-Veränderungen nach Herzinfarkt

Oehler¹,

Budinger²,

Heinrich³

et al. 1984

Klin Wochenschr

View full text Add to dashboard Cite

The antithrombin III (AT III) activity and the AT III concentration were investigated in 62 consecutive patients with acute myocardial infarction (AMI). To identify the reactant pattern of AT III in postaggressive situations, we also determined labile and acute phase proteins. Firstly, 29 patients were nourished orally and then 33 patients were fed by i.v. hyperalimentation (additional caloric intake of approximately 1,000 cal). AT III activities and concentrations as well as prealbumin and retinol-binding protein decreased concomittantly and significantly whereas haptoglobin, C-reactive protein and fibrinogen increased significantly after AMI. The changes cannot be interpreted as being alterations of the haematocrit. The alterations of AT III correlated significantly with the changes of labile proteins but not with the acute phase reactant proteins. The AT III decrease in the postinfarctional phase may promote a prethrombotic state. In addition it can be concluded from our results that AT III reacts as (nutritive-dependent) labile protein, which is lowered in postaggressive situation and does not increase as an acute phase reactant. This is in accordance with results from recent animal experiments.

show abstract

Predictive Value of Decreasing Antithrombin III in Deep-Vein Thrombosis

Cited by 3 publications

References 0 publications

Antithrombin III and Related Parameters in Surgical Patients Receiving Blood Components

Antithrombin III and Related Parameters in Surgical Patients Receiving Blood Components

Antithrombin III and Related Parameters in Surgical Patients Receiving Blood Components

Antithrombin III-Veränderungen nach Herzinfarkt

Contact Info

Product

Resources

About