Predictive value of early serum β‐hCG levels after single blastocyst transfer

Ochsenkühn, Robert; Arzberger, Andrea; Schönfeldt, Viktoria von; Engel, Jutta; Thaler, Christian J.; Noss, U.

doi:10.3109/00016340903322743

Cited by 24 publications

(21 citation statements)

References 27 publications

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“…[8] There has been published data on serum HCG as a predictor of pregnancy outcome from the western countries. [56] We present our data from the developing country in the Asian population. This is a retrospective study analyzing data in 139 patients with IVF conception.…”

Section: Discussionmentioning

confidence: 99%

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Predictive value of early serum beta-human chorionic gonadotrophin for the successful outcome in women undergoing in vitro fertilization

et al. 2013

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AIMS:Pregnancies achieved by in vitro fertilization (IVF) are at increased risk of adverse outcome. The main objective of this study was to evaluate the predictive value of β-human chorionic gonadotrophin (β-HCG) and age of the patient for the successful outcome in IVF.MATERIALS AND METHODS:A retrospective study was done in 139 pregnancies after IVF at single IVF center from June 2007 to July 2012. The age of the patient and initial serum values of β-HCG on day 14 of embryo transfer were correlated with ongoing pregnancy (>12 weeks gestation).RESULTS:The β-HCG level on day 14 of more than 347 mIU/ml has a sensitivity of 72.2% and specificity of 73.6% in prediction of pregnancy beyond 12 weeks period of gestation. Positive likelihood ratio (LR) is 2.74 and negative LR is 0.37, (receiver operating characteristic area = 0.79).DISCUSSION:In IVF cycles, there is a lot of stress on the couples while the cycle is going on. There was a positive correlation between the higher values of early serum β-HCG levels and ongoing pregnancy. Hence, it can be used as an independent predictor of a successful outcome of IVF cycle.CONCLUSION:We concluded from our study that early serum β-HCG can be used as a predictor of a successful outcome in IVF.

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Section: Discussionmentioning

confidence: 99%

“…The measurement of serum HCG levels on day 14 of ET has good sensitivity and specificity to predict pregnancy outcome in terms of viable and non-viable pregnancies. [567]…”

Section: Introductionmentioning

confidence: 99%

Predictive value of early serum beta-human chorionic gonadotrophin for the successful outcome in women undergoing in vitro fertilization

et al. 2013

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“…HCG is of placental origin, represents trophoblast functional integrity, and appears in maternal blood approximately 6 to 8 days after fertilization. Numerous studies have revealed that pregnancies with low initial hCG values are associated with a poor prognosis [2-6]. Serum hCG levels at 11 days post-ET are significantly lower for those that experience early pregnancy loss, and a cut-off of 50 mIU/mL was found to predict pregnancy outcome with good sensitivity and specificity of 75% and 81%, respectively [4].…”

Section: Introductionmentioning

confidence: 99%

“…However, the positive predictive value (PPV) of hCG at this cut-off level was around 50% and its negative predictive value (NPV) was 93% in those study. However, in two recent studies, with cut-off values of 80 and 76 mIU/mL, the PPV of hCG was 93.3% and 87% and NPV was 40% and 74%, respectively [2,3]. …”

Section: Introductionmentioning

confidence: 99%

Serum biomarkers for predicting pregnancy outcome in women undergoing IVF: human chorionic gonadotropin, progesterone, and inhibin A level at 11 days post-ET

Kim

Shin

et al. 2012

Clin Exp Reprod Med

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ObjectiveThis study was performed to assess the prognostic value of serum hCG, progesterone, and inhibin A levels measured at 11 days post-ET for predicting pregnancy outcome in women participating in IVF.MethodsBetween May 2005 and April 2008, sera were obtained from 70 infertile women who underwent IVF-ET at 11 days post-ET and stored. HCG, progesterone, and inhibin A levels were measured by commercial enzyme-linked immunosorbent assay kits. The predictive accuracy of hCG, progesterone, and inhibin A levels for establishment of intrauterine pregnancy and ongoing pregnancy was calculated by receiver-operating characteristic curve analysis.ResultsFor the prediction of intrauterine and ongoing pregnancy, serum hCG was better than progesterone and inhibin A. The predictive performance of progesterone and inhibin A was similar. The serum progesterone and inhibin A levels were significantly correlated each other (r=0.915, p=0.010).ConclusionA single measurement of the serum hCG level is sufficient to predict pregnancy outcome in IVF-ET patients.

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“…Most studies that evaluate early maternal serum hCG measurements and outcome are performed in an IVF setting (7)(8)(9)(10)(11)(12). The specific advantages of this population include accurate pregnancy dating and meticulous early pregnancy surveillance.…”

mentioning

confidence: 99%

Predictive value of maternal serum human chorionic gonadotropin levels in pregnancies achieved by in vitro fertilization with single cleavage and single blastocyst embryo transfers

Oron

Esh-Broder

Son

et al. 2015

Fertility and Sterility

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Predictive value of early serum β‐hCG levels after single blastocyst transfer

Abstract: The predictive value of a single beta-hCG measurement for pregnancy outcome after single blastocyst transfer increases between days 11 and 21 after OR. A single beta-hCG measurement on day 14 may balance the accuracy of prediction and the necessity of an early reassuring test.

Cited by 24 publications

References 27 publications

Predictive value of early serum beta-human chorionic gonadotrophin for the successful outcome in women undergoing in vitro fertilization

Predictive value of early serum beta-human chorionic gonadotrophin for the successful outcome in women undergoing in vitro fertilization

Serum biomarkers for predicting pregnancy outcome in women undergoing IVF: human chorionic gonadotropin, progesterone, and inhibin A level at 11 days post-ET

Predictive value of maternal serum human chorionic gonadotropin levels in pregnancies achieved by in vitro fertilization with single cleavage and single blastocyst embryo transfers

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