Predictive value of familiality, stressful life events and gender on the course of obsessive-compulsive disorder

Goldberg, Ximena; Soriano‐Mas, Carles; Alonso, Pino; Segalás, Cinto; Real, Eva; López-Solà, Clara; Subirà, Marta; Via, Esther; Jiménez‐Murcia, Susana; Menchón, José M.; Cardoner, Narcı́s

doi:10.1016/j.jad.2015.06.047

Cited by 26 publications

(12 citation statements)

References 42 publications

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“…There are several mechanisms that may explain the relationship we found between OCD, insecure attachment and depressive symptoms. First, maladaptive emotion regulation is common to these three constructs; a recent study demonstrated that expressive suppression of affect was related to negative affect, which contributed to OCD symptoms [58]. This is in line with the current finding, which suggests that OCD and depressive symptoms are prospectively related, particularly in cases of insecure attachment, which is strongly related to non-adaptive self-regulation of emotion and stress [59].…”

Section: Discussionsupporting

confidence: 88%

The long-term association of OCD and depression and its moderators: A four-year follow up study in a large clinical sample

et al. 2017

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Section: Discussionsupporting

confidence: 88%

The long-term association of OCD and depression and its moderators: A four-year follow up study in a large clinical sample

et al. 2017

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“…Additionally, more women than men were included (54 women versus 38 men). Previous research indicated that OCD male patients show a higher vulnerability for more severe disease manifestation (Goldberg et al, 2015). Moreover, OCD is a very heterogeneous disease with different symptomatic dimensions (contamination/cleaning, symmetry/repeating/ordering/counting, sexual/religious/aggressive, and harming) (American Psychiatric Association, 2013).…”

Section: Discussionmentioning

confidence: 99%

The efficacy of biofeedback approaches for obsessive-compulsive and related disorders: A systematic review and meta-analysis

Ferreira

Pêgo

Morgado

2019

Psychiatry Research

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A B S T R A C TBiofeedback is applied to target excessive and/or deficient physiological signals to help patients identifying and self-managing their symptoms. Biofeedback has been employed in psychiatric disorders, including obsessivecompulsive disorder (OCD), mainly by using neural signals -neurofeedback. Recently, OCD has been integrated into the obsessive-compulsive and related disorders (OCD&RD) category (body dysmorphic, hoarding, trichotillomania/hair-pulling, and excoriation/skin-picking disorders). The efficacy of biofeedback for OCD&RD is still unknown. Our work provides a complete overview of publications assessing the therapeutic efficacy of biofeedback in OCD&RD with a systematic review and meta-analysis. We found ten studies involving 102 OCD participants (three randomized controlled trials) mostly applying neurofeedback (one publication used thermal biofeedback). Five neurofeedback studies were selected for meta-analysis (89 patients; two randomized controlled trials). The overall effect size within the treatment group varied between medium to large, but high heterogeneity and inconsistency values were found. The methodological quality was low indicating a high risk of bias. In conclusion, a beneficial effect of neurofeedback for OCD patients was found but also critical limitations on methodology, high heterogeneity among studies, and a putative reporting bias. Future research following high-quality guidelines should be conducted to address the efficacy of biofeedback approaches for OCD&RD.

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“…Age at onset of MDD was defined as the age at which symptoms became a significant source of distress and interfered with the patient's functioning (Goldberg et al, 2015). Symptom severity at time of inclusion in the study was assessed with the 17-item Hamilton Depression Rating Scale (HAM-D-17) (Hamilton, 1960).…”

Section: Demographic and Clinical Assessmentmentioning

confidence: 99%

Childhood maltreatment and risk for suicide attempts in major depression: a sex-specific approach

Goldberg

Serra-Blasco

Vicent-Gil

et al. 2019

European Journal of Psychotraumatology

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Background : Childhood maltreatment increases the risk of suicide attempts in the general population, possibly having similar effects among patients with major depressive disorder (MDD). The few studies that have addressed this association have been restricted to specific populations (e.g. treatment-resistant depression, personality disorders) and have rarely taken sex into account. Objective : To examine the impact of childhood maltreatment on suicide attempts among MDD patients above and beyond other risk factors and potential confounders, while considering potential sex-specific effects. Methods : The study assessed 165 patients with a principal diagnosis of MDD. Neurological alterations, psychiatric comorbidities, and drug abuse were reasons for exclusion. Logistic regressions using the whole sample, and divided by sex, were run to test the association between childhood maltreatment and history of suicide attempts, controlling for symptom severity, comorbidities, and treatment-resistant depression. Results : There was a significant and clinically relevant association between childhood maltreatment and history of suicide attempts in the total sample. Patients with childhood maltreatment were 3.01 times more likely to present a history of suicide attempts than patients without childhood maltreatment. A family history of psychiatric disorders also contributed to the variance of attempted suicide, but its interaction with childhood maltreatment was not statistically significant. When testing the model separately, the effect of childhood maltreatment on suicide attempts remained for females, whereas for males, age of MDD onset and Childhood Trauma Questionnaire minimization–denial scale were predictive variables. Conclusions : Childhood maltreatment is a clear predictor of suicidal behaviour among MDD patients, and this effect remains significant after controlling for potential confounders. Also, the sex of patients emerges as a relevant factor that may model the mechanisms underlying the prediction of suicide attempts. Since suicide is the main cause of premature death among MDD patients, interventions targeting childhood maltreatment should be included in preventive and clinical strategies.

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Predictive value of familiality, stressful life events and gender on the course of obsessive-compulsive disorder

Cited by 26 publications

References 42 publications

The long-term association of OCD and depression and its moderators: A four-year follow up study in a large clinical sample

The long-term association of OCD and depression and its moderators: A four-year follow up study in a large clinical sample

The efficacy of biofeedback approaches for obsessive-compulsive and related disorders: A systematic review and meta-analysis

Childhood maltreatment and risk for suicide attempts in major depression: a sex-specific approach

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