Predictive value of fasting blood glucose for serious coronary atherosclerosis in non-diabetic patients

Zhao, Tong; Gong, Hai‐Bin; Zhao, Dong; Du, Yimeng; Lu, Qinghua; Chen, Huiqiang

doi:10.1177/0300060518798252

Cited by 12 publications

(4 citation statements)

References 20 publications

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“…The results of asp rosin were consistent with Mirada [22] who reported significant changes in the concentration of asp rosin in patients with atherosclerosis when compared to the results of healthy individuals, since cardiac events occur as a result of free radicals and processes involving an inflammatory response, the beneficial effects of asp rosin in turn crush free radicals and reduce apoptosis [23]. Cumulative diabetes results are consistent with Hernandez [24] finding that HbA1c is a predictor of individuals at risk as well high blood hemoglobin is a predictor of cardiovascular disease regardless of fasting glucose levels, high glucose is not only a symptom of diabetes but also of stress in which these people have what is called the Stress hyperglycemia common for patients with arterial disease these findings are consistent with Zhao [25] and Shah [26] with high sugar concentration in atherosclerosis patients. In the case of insulin hormone this finding is consistent with Monnier [27] finding that there were significant differences in insulin concentration his elevation was linked to arterial sclerosis for the average person the concentration of insulin in the portal vein was much higher than in the systemic circulation.…”

Section: Discussionsupporting

confidence: 66%

Study of Many Biochemical and Oxidative Stress Variables in Patients with Atherosclerosis in Kirkuk City

Al-Hadidi

Al-Obaidi

2022

J. Res. Appl. Sci. Biotechnol.

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The current study was designed to detect the role of a number of chemical variables represented by fasting blood sugar, hemoglobin A1c and insulin and oxidative stress factors in atherosclerosis patients. The present study involved (70) blood samples aged between (35-65) years the first group involved (40) blood samples from atherosclerosis patients and the second group involved (30) blood samples from healthy individuals, the samples were collected from respondents at Kirkuk General Hospital and Azadi Teaching Hospital in Kirkuk for a while 2021/12/22 to 2022/2/8 and the samples were taken after eight hours of fasting and all the information was taken from the reviewers by means of a questionnaire that included age, body mass index, systolic pressure and diastolic pressure and the results were as follows: significant increase in body mass index in the group of atherosclerosis patients compared to a healthy control group at a significant level (p 0.05) and 55% of them had elevated systolic pressure rate and 40% of them had high diastolic pressure ,the results from the current study show a significant increase in the concentration of asprosin compared to the control group at a significant level (p 0.05),the results of cardiac troponin(t) show a significant increase in the concentration of troponin in the patients of atherosclerosis compared to the control group at a significant level (p 0.05). The results of the study biochemical variables have shown significant increase in fasting blood sugar in the group of atherosclerosis patients compared to a control group at a significant level (p 0.05) and the results of glycated hemoglobin Test (A1c) showed a significant increase in the group of atherosclerosis patients compared to a control group at a significant level (p 0.05) and the results of insulin showed a significant increase in the group of atherosclerosis patients compared to a control group at a significant level (p 0.05). While the results of the study of the oxidative stress which included the glutathione and malondialdehyde there was insignificant reduction in serum concentration of GSH in atherosclerosis patients at a significant level (p 0.05) compared to a control group, and it has also been noted that was a significant increase in serum concentration of MDA in the atherosclerosis patients compared to a control group at a significant level (p 0.05).

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Section: Discussionsupporting

confidence: 66%

Study of Many Biochemical and Oxidative Stress Variables in Patients with Atherosclerosis in Kirkuk City

Al-Hadidi

Al-Obaidi

2022

J. Res. Appl. Sci. Biotechnol.

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“…Furthermore, a study by Iijima R, et al demonstrated that Patients with diabetes often accelerate atherosclerotic thrombosis, resulting in early, widespread, and rapidly progressing coronary artery disease ( 18 ). Tong Zhao et al concluded that hyperglycaemia was an independent predictor of severe coronary artery disease in non-diabetic patients ( 19 ). Our study definitively confirms that the association of glycemia with multi-vessel lesions is more significant in non-diabetic patients.…”

Section: Resultsmentioning

confidence: 99%

Association between glycemia and multi-vessel lesion in participants undergoing coronary angiography: a cross-sectional study

Dong,

Liu,

Chen

et al. 2024

Front. Cardiovasc. Med.

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BackgroundThis study aims to elucidate the association between glycemia and the occurrence of multi-vessel lesions in participants undergoing coronary angiography.MethodsWe analyzed 2,533 patients with coronary artery disease who underwent coronary angiography. Of these, 1,973 patients, identified by the endpoint of multi-vessel lesions, were examined using univariate and multivariate logistic regression analyses to determine the relationship between glycemia levels and multi-vessel lesion occurrence.ResultsThe analysis included 1,973 participants, among whom 474 patients were identified with coronary multi-vessel lesions. Univariate logistic regression analysis demonstrated a positive correlation between glycemia and the occurrence of coronary multi-vessel lesions (OR 1.04; 95% CI 1.01–1.08; p = 0.02). The adjusted model indicated that for each unit increase in glycemia, the risk of developing coronary multi-vessel lesions increased by 4%, showing a significant correlation (p < 0.05). Subgroup analyses revealed that the impact of glycemia on multi-vessel lesions in patients with PCI varied according to gender, age, and smoking status, with the effect being more pronounced in men, older patients, and smokers.ConclusionOur findings establish a significant association between glycemia and the incidence of multi-vessel lesions, particularly pronounced in male patients, individuals over 45, and smokers.

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“…There are relevant studies that show hypoglycemia and hyperglycemia on admission are associated with higher in-hospital mortality, The relationship between fasting blood glucose (FBG), admitted blood glucose and mean hospitalized blood glucose and in-hospital mortality was U-shaped or J-shaped [14,[16][17][18]. Park et al found a J-shaped relationship between fasting glucose levels and the risk of atherosclerotic cardiovascular disease [19].Yuhan Qin et al reviewed 958 consecutive AMI patients undergoing emergency coronary angiography, and found that FBG was positively correlated with Gensini score (r = 0.171,P< 0.001) [10].Tong Zhao et al reviewed 64 patients with chest discomfort accompanied by coronary angiography; In patients with diabetes (r = 0.312,P<0.012) and non-diabetic patients (r = 0.387, P<0.010), FBG was positively correlated with Gensini score [11].Jingjing Jiang et al included 1852 patients with coronary angiography for analysis, and the result showed that FBG was positively correlated with Gensini score (r = 0.09,P<0.01), regression analysis showed that FBG was independently correlated with Gensini score [12].In 85 patients with acute coronary syndrome who underwent emergency coronary angiography and implanted stents when necessary, FPG was positively correlated with Gensini score (r = 0.568,P<0.000) [8].In 906 patients who underwent coronary angiography and had no history of diabetes, a signi cant positive correlation was found between FPG and Gensini score (r = 0.172; P = 0.011) [13].Previous studies used single truncation method to distinguish high-risk hyperglycemia [14], Only considering the effect of blood glucose on gensini score,but both hypoglycemia and hyperglycemia are high-risk factors for AMI. In our study, we used three fasting glucose thresholds, hypoglycemic group 5.30mmol/L (2.69-6.15), medium glycemic group 7.11mmol/L (6.…”

Section: Discussionmentioning

confidence: 99%

“…gensini score is mainly an evaluation index re ecting the severity of coronary artery lesions. The increase of FBG is correlated with Gensini score [8,9].Previous studies have shown a signi cant positive correlation between fasting glucose and gensini scores, con rming even in the non-diabetic range [10][11][12][13].It has been found in the past that there is a positive linear correlation between blood glucose and GENSINI score. Only the in uence of blood glucose on GENSINI is considered, without considering the in uence of other factors such as uric acid, creatinine and age on GENSINI.Previous meta-analyses and the original article used a single truncation to distinguish high-risk hyperglycemia [14], however,both hypoglycemia and hyperglycemia are high-risk factors for AMI.…”

Section: Introductionmentioning

confidence: 97%

U-shaped relationship between fasting blood glucose concentration and gensini sore analysis in STEMI patients

Zhong

2023

Preprint

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Background: An association between fasting blood glucose (FBG) and gensini scores has been reported. However, no studies have investigated the relationship between ST elevation myocardial infarction and FBG. The purpose of this study was to investigate the association between FBG and coronary artery disease severity score (Gensini score) in patients with ST-segment elevation (STEMI) myocardial infarction. Methods: In a retrospective analysis of 464 enrolled patients, we used minimum absolute contraction and selection operator (lasso) regression analysis to screen for covariates; In multiple regression analyses, we used gensini scores as the dependent variable, glucose as the independent variable, Fasting blood glucose was divided into hypoglycemic group 5.30mmol/L (2.69-6.15), medium glycemic group 7.11mmol/L (6.19-8.61) and hyperglycemic group 10.70mmol/L (8.64-14.81)，and selected variables as covariates to adjust and observe the true association between glucose and gensini scores. Considering that there is not necessarily a linear relationship between blood glucose and Guernsini score in the real world, we used curve fitting to observe the changing trend of blood glucose and Guernsini score. Results: When confounding factors are not adjusted, The gensini scores in the medium-glycemic and high-glycemic groups had significant clinical significance (the medium-glycemic group, 95%CI: -140162--0.213, P=0.044; Hyperglycemia group, 95%CI: 5.295-19.221, P=0.0006;) The relationship between fasting blood glucose and Guernsini score is U-shaped but non-linear. Using minimum absolute contraction and selection operator (LASSO) regression to select variables, Variables included neutrophils, hemoglobin, platelets, albumin, low-density lipoprotein, D-dimer, urea nitrogen, glucose, white blood cells, systolic blood pressure, heart rate, age, dm, culprit vessel, history of myocardial infarction, Killip grade, number of stents, creatinine, uric acid, total cholesterol,CTNI, CKMB, left ventricular end-diastolic diameter, left atrial diameter. After adjusting for confounder factors, only the hyperglycemic group had significant clinical significance in Gensini score (95%CI: -16.95--2.71, P=0.015). Curve fitting analysis showed that fasting glucose and Gensini score presented a U-shaped but non-linear relationship in patients diagnosed with or without diabetes. Conclusions: The severity of coronary stenosis in patients with ST-segment elevation myocardial infarction is influenced by either excessively high or excessively low fasting glucose concentration,Whether people with or without diabetes.

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Predictive value of fasting blood glucose for serious coronary atherosclerosis in non-diabetic patients

Cited by 12 publications

References 20 publications

Study of Many Biochemical and Oxidative Stress Variables in Patients with Atherosclerosis in Kirkuk City

Study of Many Biochemical and Oxidative Stress Variables in Patients with Atherosclerosis in Kirkuk City

Association between glycemia and multi-vessel lesion in participants undergoing coronary angiography: a cross-sectional study

U-shaped relationship between fasting blood glucose concentration and gensini sore analysis in STEMI patients

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