Predictive Value of Laboratory Indexes on Renal Involvement in Children with Henoch-Schönlein Purpura

Xi, Leying; Xu, Shuang; Sun, Y. T.; Wen, Yingying; Wu, Jingjing; Ren, Xianqing

doi:10.2147/ijgm.s337437

Cited by 3 publications

(1 citation statement)

References 27 publications

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“…With regards to the role of serum IgA, some studies have reported that serum IgA concentration is associated with nephritis in children with IgAV [ 8 , 16 ], but results are conflicting [ 11 , 17 ]. Our study found no significant difference in the serum IgA analyses, and a previous meta-analysis concluded that increased serum IgA levels were not associated with kidney involvement in IgAV [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

Increased Urinary IgA in Paediatric IgA Vasculitis Nephritis

Marro

Chetwynd

Edwards

et al. 2022

IJMS

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IgA vasculitis (IgAV) is the most common form of paediatric vasculitis, with up to 50% of patients experiencing kidney inflammation. Much remains unknown about IgAV, but it is believed to arise due to galactose-deficient IgA1 promoting an auto-inflammatory response. This study assesses whether urinary IgA can be detected in children with IgAV to allow further evaluation of IgA1 and whether it has any relationship with nephritis. Urinary and serum IgA concentrations were measured using commercially available ELISA kits. Patients were grouped into IgAV nephritis (IgAVN) or IgAV without nephritis (IgAVwoN). Fifty-nine children were included: IgAVN n = 12, IgAVwoN n = 35, and healthy controls (HC) n = 12, with a mean age of 8.2 ± 4.1 years. Urinary IgA concentrations were statistically significantly higher in patients with IgAV (107.1 ± 136.3 μg/mmol) compared to HC (50.6 ± 26.3 μg/mmol; p = 0.027) and IgAVN (229.8 ± 226.3 μg/mmol) compared to both IgAVwoN (65.0 ± 37.8 μg/mmol; p = 0.002) and HC (p < 0.001). Urinary IgA concentrations were able to distinguish between renal status (AUC 0.838, 95%CI [0.704–0.973], p < 0.001) and did not correlate with proteinuria (r = 0.124; p = 0.407). Urinary IgA concentrations are increased in children with IgAVN, and it has the potential to act as a non-invasive biofluid to further evaluate nephritis in this disease.

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