Predictive value of mean platelet volume in young patients with non-ST-segment elevation acute coronary syndromes: a retrospective observational study

Abstract

Predictive value of mean platelet volume in young patients with non-ST-segment elevation acute coronary syndromes: a retrospective observational study ST-yükselmesiz ABSTRACTObjective: Platelets play an important role in both initiation and propagation of acute coronary syndromes. We sought to evaluate the predictive value of mean platelet volume (MPV) in young patients with non-ST-segment elevation acute coronary syndromes (NSTE-ACS).Methods: This is a retrospective observational study; evaluating the MPV values of 79 NSTE-ACS patients aged under 45 years and 45 control subjects having normal coronary anatomy. NSTE-ACS group was composed of 41 non-ST elevation myocardial infarction (NSTEMI) and 38 unstable angina pectoris (USAP) patients. MPV was measured using an automated hematologic analyzer called Coulter counter. The predictive value of MPV was evaluated using logistic regression analysis and comparison of MPV between NSTE-ACS and control groups was performed by Mann-Whitney U test. Results: The MPV was found to be significantly higher in the NSTE-ACS compared with control group (8.49±1.22 versus 7.78±0.65 fL, p=0.001).In logistic regression analysis, MPV was found to be an independent predictor of NSTE-ACS (OR=3.1, 95% CI 1.

The New Diagnostic Marker For Acute Pulmonary Embolism In Emergency Department; Mean Platelet Volume

“…Recently, clearly known that increased MPV is shown more reactive platelets. We also known that increased in MPV is closely correlated with thrombosis and to reflect thrombosis burden in different condition and increase in MPV has been identified as an independent risk factor of recurrent vascular events [9][10][11]16 . Previous studies showed that there is the hypercoagulable/prothrombotic state in APE, which is also important in development of thrombosis 17 .…”

“…Previous studies have shown that MPV is a marker of platelet function and is positively associated with indicators of platelet activity [5][6][7]9 . Recently, clearly known that increased MPV is shown more reactive platelets.…”

“…MPV is an indicator of platelet activation and there is strong evidence indicating that MPV is an important variable and that larger platelets have a higher thrombotic potential 5,6 . Elevated MPV has been recognized as an independent risk factor for different clinical conditions [7][8][9] . Recently, previous studies clearly showed that MPV was associated with acute deep venous thrombosis (DVT) and high levels of MPV might increase the specificity of D-dimer for exclusion of DVT 10,11 .…”

Predictive Value of Mean Platelet Volume in Saphenous Vein Graft Disease

“…Vasoactive mediators secreted by the platelets may contribute to inflammation and the process of atherogenesis. Increased risk of acute coronary syndrome in patients with high MPV may be explained by increased platelet activity, inflammation, and platelet aggregation [10] . MPV has been found to be more closely related to platelet function than to platelet count.…”

The prognostic value of white blood cell count-to-mean platelet volume ratio in patients with acute coronary syndrome

“…On the other hand, MPV is another recent hematologic parameter being extensively investigated. A number of studies have demonstrated that higher MPV values are associated with poorer long-term outcome in patients presented with ACS [13][14][15]. Therefore, increased levels of both WBC and MPV levels were shown to be associated with adverse CV outcomes; the proposed novel marker, WMR, would most likely blunt the predictive power of these parameters, as a result of dividing WBC by MPV.…”