Predictive value of modelled tumour control probability based on individual measurements of<i>in vitro</i>radiosensitivity and potential doubling time

Hedman, M.; Björk‐Eriksson, Thomas; Brodin, Ola; Toma-Daşu, Iuliana

doi:10.1259/bjr.20130015

Cited by 13 publications

(19 citation statements)

References 25 publications

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“…To calculate surviving fraction (SF) and tumor control probability (TCP) with regard to biologically effective dose (BED), by using breast cancer radiobiological parameters and the following equations: [14][15][16] ln(SF)= -E [17,18] I S S N 2347-3 4 8 7 Where: n (the number of well-spaced and identical fractions) =15 fractions, d (the dose per fraction) =2.67 Gy (hypofractionation regimen 40 Gy/15 fractions) [16]. (α/β) ratio (is the linear to quadratic coefficients in the linear quadratic (LQ) model, and represents the dose at which single and double-hit killing events are equal in number; at higher doses double-hit killing events start to progressively dominate) = 4 Gy [19].…”

Section: Radiobiological Calculationsmentioning

confidence: 99%

“…N0 (the initial number of clonogens in the tumor) = 109. V [15]. The density of clonogens per cubic centimeter (cc) =109 [15].…”

Section: Radiobiological Calculationsmentioning

confidence: 99%

“…V [15]. The density of clonogens per cubic centimeter (cc) =109 [15]. There is general agreement in the literature that 1 cm3 tumor mass contains, 10 9 cells [21].…”

Section: Radiobiological Calculationsmentioning

confidence: 99%

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Study the Influence of Treatment Interruptions in the Radical Irradiation of Breast Cancer

Azam

Oraby

Awad

et al. 2017

JAP

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Hypofractionated radiotherapy (HFRT) in breast cancer treatment regimen (40 Grey /15 fractions/3 weeks) is more convenient for patients, especially those coming from remote areas to radiotherapy facilities and for healthcare providers, than conventional fractionation (50 Gy/25 fractions/5weeks). So the effectof radiotherapy interruption on treatment outcome (loco-regional control (LRC)& overall survival (OS)) during hypofractionated schedule is the issue of our study.Materials and Methods: We studied retrospectively 174 female patients with breast cancer who received PORT at the Clinical Oncology & Nuclear Medicine Department, Faculty of Medicine, Mansoura University, Egypt, from January-2012 to December-2016. We determined the treatment outcome (OS&LRC) from the follow-up (FU) of the studied patients, as the patient still survived or died, and recurrence till now occurred or not, and were estimated with the Kaplan-Meier (K-M) method and Logrank test, respectively. Then we calculated surviving fraction (SF) and tumor control probability (TCP) with regard to biologically effective dose (BED), for all patients, using breast cancer radiobiological parameters.Results: When comparing patients without radiotherapy gap with patients with radiotherapy gaps, the results showed a decrease in LRC rate in patients with radiotherapy treatment interruptions by 15 % (P=0.019, a significant value), but no detrimental effect on OS because of the very limited number of the studied patients. Curves of the relationship between (SF&OTT) and (TCP&OTT) confirmed the detrimental effect of unscheduled gap during radiotherapy fractions on the treatment outcome. Also we found a significant-P value for (marital status, start day of radiotherapy fractions, time, number, and duration of gaps); it means these factors affect LRC during radiotherapy interruptions.Conclusions: Interruptions during postoperative hypofractionated irradiation of breast cancer (40 Gy/15 fractions/3weeks) should be avoided and if they are inevitable, they should not be prolonged more than two days, as they will adversely affect the treatment outcome (LRC).

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Section: Radiobiological Calculationsmentioning

confidence: 99%

“…N0 (the initial number of clonogens in the tumor) = 109. V [15]. The density of clonogens per cubic centimeter (cc) =109 [15].…”

Section: Radiobiological Calculationsmentioning

confidence: 99%

See 1 more Smart Citation

Study the Influence of Treatment Interruptions in the Radical Irradiation of Breast Cancer

Azam

Oraby

Awad

et al. 2017

JAP

View full text Add to dashboard Cite

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“…A large multicentre analysis also failed to correlate experimental determinations of T pot with treatment outcome in head and neck cancers [34]. However, a more recent analysis has shown that pretreatment proliferation parameters are better predictors of outcome when other factors like tumour size, individual radiosensitivity and overall treatment time are taken into account [35].…”

Section: Repopulationmentioning

confidence: 99%

The Six Rs of Head and Neck Cancer Radiotherapy

Marcu¹,

Toma-Daşu²,

Daşu³

2015

Contemporary Issues in Head and Neck Cancer Management

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“…Radiotherapy has been commonly used in clinics for treatment of cancer 2 . The total dose estimation for patient plays an important role in maximizing the effectiveness of treatment which is decided by various factors like type of tumour, size, and proliferation 3 .…”

Section: Introductionmentioning

confidence: 99%

Response of Normal Cells Following Multiple Radiation Exposure under Radiotherapy Setting

et al. 2017

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Radiotherapy is an established approach for killing of tumour cells. During the process, most of the normal cells also get affected due to direct exposure or by bystander effects. To measure the damage pattern in healthy cells, a pilot study was designed under radiotherapy settings. Right leg region of Strain ‘A’ male mice was locally exposed to Cobalt60 gamma radiation with a dose of 2 Gy/ day for 5 consecutive days. After completion of each fraction, blood haematology and γH2AX studies were performed at 1 h time point in blood and bone marrow cells. Chromosomal aberration study in bone marrow was carried out at 24 h post irradiation of each fraction for evaluation of DNA damage. γH2AX and chromosomal aberration were found significantly (p<0.001) increased with each consecutive dose upto 4th fractions. Blood hematology showed a linear reduction in total WBC counts which included the reduction in lymphocytes and increased granulocytes with each passing dose up to 4th fraction. However, non significant damage (p>0.05) for all parameters have been observed for 4th and 5th split doses. The study indicated that repeated exposure leads to damage fixation in normal cells, possibly indicating a state of adaptation.

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Predictive value of modelled tumour control probability based on individual measurements ofin vitroradiosensitivity and potential doubling time

Cited by 13 publications

References 25 publications

Study the Influence of Treatment Interruptions in the Radical Irradiation of Breast Cancer

Study the Influence of Treatment Interruptions in the Radical Irradiation of Breast Cancer

The Six Rs of Head and Neck Cancer Radiotherapy

Response of Normal Cells Following Multiple Radiation Exposure under Radiotherapy Setting

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