Predictive value of perioperative gastric acid tests.

Hood, John; Spencer, E. F. A.; MacRae, K D; Kennedy, T. L.

doi:10.1136/gut.17.12.998

Cited by 9 publications

(2 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Basal acid output, however, was higher both before and after operation in patients who suffered recurrent ulceration after highly selective vagotomy than in patients who did not have recurrences; this has been noted before. 24 When the peak acid responses to pentagastrin in patients with recurrent ulceration were compared with those in patients without recurrence no significant differences were found either before or after operation.…”

Section: Discussionmentioning

confidence: 99%

Highly selective vagotomy and duodenal ulcers that fail to respond to H2 receptor antagonists

Primrose

Axon²,

Johnston³

1988

BMJ

View full text Add to dashboard Cite

A study was conducted to see whether patients with duodenal ulcers that failed to heal in response to H2 receptor antagonists had a higher incidence of recurrent ulceration after highly selective vagotomy than patients whose ulcers healed with these drugs. Between 1977 and, 157 patients had a highly selective vagotomy for uncomplicated duodenal ulcer; in 57 patients the ulcer had failed to heal despite treatment with H2 receptor antagonists (refractory group), 19 patients had developed recurrent ulceration while receiving maintenance treatment, 67 patients had remained healed while taking H2 receptor antagonists but suffered frequent relapses when treatment was stopped, and 14 patients had not been given these drugs before operation. The overali incidence of recurrent ulceration was 6% after two years and 11% after five years of foliow up. In the refractory group, however, the incidence of recurrent ulceration was 18% at two years and 34% after five years, whereas the incidence of recurrence was only 1-5% at two years and 3% after five years in patients whose ulcers had healed with H2 receptor antagonists. Resistance to H2 receptor antagonists was not related to preoperative basal or peak acid output but was related to cigarette smoking. Factors associated with recurrent ulceration after highly selective vagotomy were basal acid outputs before and after operation, cigarette smoking, and the surgeon who performed the operation.Duodenal ulcers that fail to respond to H2 receptor antagonists represent a more severe ulcer diathesis, for which highly selective vagotomy is less effective.

show abstract

Section: Discussionmentioning

confidence: 99%

Highly selective vagotomy and duodenal ulcers that fail to respond to H2 receptor antagonists

Primrose

Axon²,

Johnston³

1988

BMJ

View full text Add to dashboard Cite

show abstract

“…However, a percentage of patients undergoing surgery develop undesirable side effects related to abnormalities of motility. Truncal vagotomy and pyloroplasty has a higher morbidity than highly selective vagotomy and pyloroplasty (22); however, the latter procedure is attended by a higher recurrence rate of peptic ulcer when performed on patients with acid hypersecretion (12,13). This assertion has been challenged by others (23).…”

Section: Patientmentioning

confidence: 99%

Marked Basal Gastric Acid Hypersecretion and Peptic Ulcer Disease

Hyman,

Hassall

1988

J. pediatr. gastroenterol. nutr.

View full text Add to dashboard Cite

SummaryThree children with peptic ulcer disease had recurrent symptoms unresponsive to cimetidine or ranitidine therapy alone. Acid secretory studies showed a marked basal acid hypersecretion, which was atropinesensitive in two of three patients and was best suppressed by ranitidine in combination with an anticholinergic drug. Marked reduction in acid output following intravenous atropine suggested that the hypersecretion was under vagal, muscarinic control. However, in one patient, large doses of the selective m1‐muscarinic antagonist pirenzepine were ineffective in suppressing basal acid hypersecretion. Given the efficacy and safety of drug therapy used in these children over a 3‐year period, we conclude that medical management is an effective alternative to surgery for pediatric patients with refractory or recurrent peptic ulcer disease.

show abstract

Magensekretion

Koelz¹

1985

Interdisziplinäre Gastroenterologie

View full text Add to dashboard Cite

Predictive value of perioperative gastric acid tests.

Cited by 9 publications

References 12 publications

Highly selective vagotomy and duodenal ulcers that fail to respond to H2 receptor antagonists

Highly selective vagotomy and duodenal ulcers that fail to respond to H2 receptor antagonists

Marked Basal Gastric Acid Hypersecretion and Peptic Ulcer Disease

Magensekretion

Contact Info

Product

Resources

About