Predictive value of plasma cytokines for acute kidney injury following lung resection surgery: prospective observational study

Matesanz, Cristina Monteserín; Gala, F. de la; Rancán, Lisa; Piñeiro, Patricia; Simón, Carlos; Tejedor, Alberto; Vara, Elena; González‐Cantero, Álvaro; Garutti, Ignacio

doi:10.1016/j.bjane.2019.03.005

Cited by 3 publications

(18 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Among the above, independent AKI predictors proved to be IL-8 and NGAL. It is consistent with the results obtained by other authors [ 6 , 13 , 15 , 18 , 21 , 34 ]. Another advantage of NGAL, MMP-9 and IL-18 usage in this instant is that they are marked in urine; therefore, the test is non-invasive.…”

Section: Discussionsupporting

confidence: 93%

See 1 more Smart Citation

Assessment and Prognosis in CSA-AKI Using Novel Kidney Injury Biomarkers: A Prospective Observational Study

Udzik

Waszczyk

Safranow

et al. 2021

Biology

View full text Add to dashboard Cite

Background: There is a need for early diagnostic solutions for cardiac surgery associated acute kidney injury (CSA-AKI) as serum creatinine changes do not occur dynamically enough. Moreover, new approaches are needed for kidney protective strategy in patients undergoing cardiac surgery procedures; Methods: Samples of serum and urine were taken from the selected group of patients undergoing elective cardiac surgery procedures. The aim of this study was to assess the utility of specific inflammation and kidney injury biomarkers in the early diagnostic of CSA-AKI and in the prognosis of long-term postoperative kidney function; Results: At 6 h after weaning from cardiopulmonary bypass, there were significant differences in IL-6, IL-8, TNF-α, MMP-9 and NGAL concentrations in patients with CSA-AKI, compared to the control group. Serum IL-8 and urine NGAL 6 h after weaning from CPB proved to be independent acute kidney injury predictors. The TNF-α, MMP-9, IL-18, TIMP-1 and MMP-9/TIMP-1 ratio in the early postoperative period correlated with long-term kidney function impairment; Conclusions: Novel kidney injury biomarkers are an eligible tool for early diagnosis of CSA-AKI. They are also reliable indicators of long-term postoperative kidney function impairment risk after cardiac surgery procedures.

show abstract

Section: Discussionsupporting

confidence: 93%

“…For this reason, it is used in scientific studies to diagnose CSA-AKI. Its serum concentration is significantly higher 6 h after the operation in patients with AKI compared to the control group [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Assessment and Prognosis in CSA-AKI Using Novel Kidney Injury Biomarkers: A Prospective Observational Study

Udzik

Waszczyk

Safranow

et al. 2021

Biology

View full text Add to dashboard Cite

show abstract

“…In total, our search identified 1260 records of which 113 records were removed as duplicates and a further 1091 records were excluded for not meeting our eligibility criteria upon the screening of the title and abstract. After a full-text examination, 18 studies met our selection criteria [5][6][7][8][9][10][11][12][27][28][29][30][31][32][33][34][35][36]. The reference lists for the bibliographies of the text articles were screened, which revealed two reports that met our inclusion criteria [19,37].…”

Section: Resultsmentioning

confidence: 99%

“…Table 1 presents the clinical characteristics of all the included studies. Of the 20 studies analyzed, 15 were retrospective observational studies [5-7,9,19,27-31,33-37], 4 were prospective observational studies [8,11,12,32], and 1 was a retrospective nested casecontrol study [10]. Two studies documented mixed thoracic surgical populations [19,29], thirteen documented lung surgical populations [5,7,9,11,12,27,30,[32][33][34][35][36][37], and five were of esophageal surgical populations [6,8,10,28,31].…”

Section: Resultsmentioning

confidence: 99%

Incidence and Associations of Acute Kidney Injury after General Thoracic Surgery: A System Review and Meta-Analysis

Yan

et al. 2022

JCM

View full text Add to dashboard Cite

(1) Background: Acute kidney injury (AKI) is related to adverse outcomes in critical illness and cardiovascular surgery. In this study, a systematic literature review and meta-analysis was carried out to evaluate the incidence and associations of AKI as a postoperative complication of thoracic (including lung resection and esophageal) surgical procedures. (2) Methods: Adopting a systematic strategy, the electronic reference databases (PubMed, EMBASE, and Cochrane Library) were searched for articles researching postoperative renal outcomes that were diagnosed using RIFLE, AKIN or KDIGO consensus criteria in the context of a thoracic operation. A random-effects model was applied to estimate the incidence of AKI and, where reported, the pooled relative risk of mortality and non-renal complications after AKI. The meta-analysis is registered in PROSPERO under the number CRD42021274166. (3) Results: In total, 20 studies with information gathered from 34,826 patients after thoracic surgery were covered. Comprehensively, the incidence of AKI was estimated to be 8.8% (95% CI: 6.7–10.8%). A significant difference was found in the mortality of patients with and without AKI (RR = 2.93, 95% CI: 1.79–4.79, p < 0.001). Additionally, in patients experiencing AKI, cardiovascular and respiratory complications were more common (p = 0.01 and p < 0.001, respectively). (4) Conclusions: AKI is a common complication associated with adverse outcomes following general thoracic surgery. An important issue in perioperative care, AKI should be considered as a highly significant prognostic indicator and an attractive target for potential therapeutic interventions, especially in high-risk populations.

show abstract

“…Likewise, the study by Mendoҫa and coworkers also found a relationship between increased creatinine and IFN-γ [ 39 ]. Recruitment of inflammatory cells to the kidneys, such as neutrophils and macrophages that release pro-inflammatory cytokines, contribute to the activation of renal and tubular endothelial cells, generating alterations in the vascular, tubular and glomerular functions of the kidneys [ 40 , 41 ]. In this way, it is possible that pro-inflammatory cytokines in the patients in our study contributed to renal dysfunction.…”

Section: Discussionmentioning

confidence: 99%

IL-4, IL-10, CCL2 and TGF-β as potential biomarkers for severity in Plasmodium vivax malaria

et al. 2022

View full text Add to dashboard Cite

Cytokines and chemokines are immune response molecules that display diverse functions, such as inflammation and immune regulation. In Plasmodium vivax infections, the uncontrolled production of these molecules is thought to contribute to pathogenesis and has been proposed as a possible predictor for disease complications. The objective of this study was to evaluate the cytokine profile of P. vivax malaria patients with different clinical outcomes to identify possible immune biomarkers for severe P. vivax malaria. The study included patients with non-severe (n = 56), or severe (n = 50) P. vivax malaria and healthy controls (n = 50). Patient plasma concentrations of IL-4, IL-2, CXCL10, IL-1β, TNF-α, CCL2, IL-17A, IL-6, IL-10, IFN-γ, IL-12p70, CXCL8 and active TGF-β1 were determined through flow cytometry. The levels of several cytokines and chemokines, CXCL10, IL-10, IL-6, IL-4, CCL2 and IFN-γ were found to be significantly higher in severe, compared to non-severe P. vivax malaria patients. Severe thrombocytopenia was positively correlated with IL-4, CXCL10, IL-6, IL-10 and IFN-γ levels, renal dysfunction was related to an increase in IL-2, IL-1β, IL-17A and IL-8, and hepatic impairment with CXCL10, MCP-1, IL-6 and IFN-γ. A Lasso regression model suggests that IL-4, IL-10, CCL2 and TGF-β might be developed as biomarkers for severity in P. vivax malaria. Severe P. vivax malaria patients present specific cytokine and chemokine profiles that are different from non-severe patients and that could potentially be developed as biomarkers for disease severity.

show abstract

Predictive value of plasma cytokines for acute kidney injury following lung resection surgery: prospective observational study

Cited by 3 publications

References 24 publications

Assessment and Prognosis in CSA-AKI Using Novel Kidney Injury Biomarkers: A Prospective Observational Study

Assessment and Prognosis in CSA-AKI Using Novel Kidney Injury Biomarkers: A Prospective Observational Study

Incidence and Associations of Acute Kidney Injury after General Thoracic Surgery: A System Review and Meta-Analysis

IL-4, IL-10, CCL2 and TGF-β as potential biomarkers for severity in Plasmodium vivax malaria

Contact Info

Product

Resources

About