Predictive Value of Preoperative Neutrophil-Lymphocyte and Platelet-Lymphocyte Ratio in Determining the Stage of Colon Tumors

Turhan, Veysel Barış; Ünsal, Alaattin; Gök, Halil Fatih; Öztürk, Bülent; Öztürk, Doğan; Şimşek, Gülçin Güler; Buluş, Hakan

doi:10.7759/cureus.18381

Cited by 12 publications

(12 citation statements)

References 21 publications

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“…In recent years, there has also been many researchs about platelet indices and cancer diagnosis, and cancer stage (21). Yang-Yang Wu et al (22) found in their study about colorectal cancer MPV/PC was significantly different in subgroups between patients with stage I/II and stage III/IV cancer, and they believed that this ratio might be helpful in the differential diagnosis of early and advanced colorectal cancer.…”

Section: Discussionmentioning

confidence: 98%

Diagnostic and prognostic value of the ratio of mean platelet volume to platelet count in acute mesenteric ischemia

ÖZKAN

TOPÇU

ŞAHİN>

et al. 2022

Journal of Health Sciences and Medicine

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Introduction: Acute mesenteric ischemia (AMI) is a condition in which there is a sudden cessation of blood supply to a particular intestinal segment and consequent cellular damage. Although it has a low incidence of approximately 0.09-0.2% of all emergency surgery admissions, AMI is a severe condition that can cause high early mortality. A direct relationship between an increased mean platelet volume (MPV) and acute thrombotic events has been shown in recent years. we aimed to find out whether the diagnosis of mesenteric ischemia and the amount of bowel segment affected by ischemia will guide clinicians preoperatively with these markers Material and Method: A total of 57 cases with bowel resection due to mesenteric ischemia were included in the study. The gender, age, serum platelet (PLT), MPV, white blood cell count (WBC), neutrophil count (NEU), lymphocyte count (LYM), Albumin, CRP, neutrophil-lymphocyte ratio (NLR), MPV/Platelet Count, and CRP-albumin ratio (CAR) levels at the time of admission, operation time, length of resected bowel segment, length of hospital stay, presence of necrosis and perforation from pathology reports, and length of bowel segment leading to necrosis were scanned. Results: A moderate (moderate) negative correlation was found between the length of resected bowel segment and PLT (P<0.001; r=-0.685). A moderate positive significant correlation was found between resection length and MPV (P<0.001; r=0.565). A high significant positive correlation was found between resection length and MPV/PC (P<0.001; r=0.857). PLT, WBC and MPV/PC values were statistically different between the perforated group and no-perforation group (p=0.009, p=0.024, p=0.010). WBC and MPV/PC values were significantly higher in the perforated group. Conclusion: MPV/PC and PLT value at hospital admission is a reliable and simple predictive factor in determining perforation and the amount of bowel segment affected in patients with acute mesenteric ischemia.

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Section: Discussionmentioning

confidence: 98%

Diagnostic and prognostic value of the ratio of mean platelet volume to platelet count in acute mesenteric ischemia

ÖZKAN

TOPÇU

ŞAHİN>

et al. 2022

Journal of Health Sciences and Medicine

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“…It has also been questioned due to a potential limitation of stage migration in gastric cancer, and it has been suggested that the lymph node ratio be used to overcome this staging problem for patients with lymph node who have been studied in small numbers; the hypothesis is that the N-ratio may represent the true burden of lymph node metastases. 14 , 15 In a large cohort of conventional lymph node dissections, N-Ratio staging was found to be superior to AJCC TNM N-staging. 16 The N-ratio cut-off value in this study was 0.32.…”

Section: Discussionmentioning

confidence: 99%

Does lymph node ratio (metastasis/total lymph node count) affect survival and prognosis in gastric cancer?

TOPÇU

Şahiner

Kendirci

et al. 2022

SMJ

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Objectives: To investigate the influence of the metastatic lymph node/total lymph node ratio (N-ratio) on survival and prognosis in surgically treated gastric carcinomas. Methods:A retrospective review of 73 patients who underwent curative resection at the Department of General Surgery, Hitit University Faculty of Medicine, Turkey. Receiver operating characteristic analysis was used to calculate the cut-off value for the N-ratio of the patients. The N-ratio cut-off value was determined to be 0.32. Patients were divided into 2 groups: below 0.32 (Group 1) and 0.32 and above 0.32 (Group 2). Original ArticleResults: Group 2 patients had a total lymph node mean of 25.10±13.64 while Group 1 patients had a total lymph node mean of 18.77±9.36 (p=0.04). In Group 2, the mean of metastatic lymph node was 15.97±10.30 (p<0.001). The mortality rate of Group 1 was 18% while Group 2 was 51.7%, and were statistically significant (p=0.0039). The estimated survival duration of Group 2 was 24.22 months, and Group 1 was 48.01 months (p=0.001). The mean estimated survival time for the entire group was 40.92 months. We differentiated patients from the development of mortality cut-off value in ROC analysis with 65.2% sensitivity and 72% specificity. This ratio was found to be 0.32, which was statistically significant (p=0.003). Ratios greater than 0.32 raised the risk of mortality by 4.8 times, which was statistically significant (p=0.003). Conclusion:The N-ratio could be a new metric to evaluate prognosis following curative gastrectomy and improve the existing tumor lymph node metastasis staging system.

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“…Turhan et al [15], reported a significant relationship between NLR values and colorectal cancer stage and no significant relationship between PLR values and colorectal cancer stage. In the research of Rohit Krishna and Anil Kumar [16], NLR values increase according to the stage of colorectal cancer, from stage I to stage II to stage III, but NLR values at stage IV are lower than stage III.…”

Section: Patients Selectionmentioning

confidence: 97%

Neutrophil to Hemoglobin Lymphocyte Ratio (NHLR) as a Novel Biomarker is Superior to Neutrophil Lymphocyte Ratio (NLR) and Platelet Lymphocyte Ratio (PLR) as Predictors of Advanced Colorectal Cancer

Purnomo,

Handaya,

Setyawan

2024

Indonesian Journal of Cancer

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Background: Neutrophils, Hemoglobin, and Lymphocytes are biological markers that may be related to the colorectal cancer stage. Neutrophils to Hemoglobin-Lymphocytes Ratio (NHLR) is a new biomarker that will be tested with Neutrophil Lymphocyte Ratio (NLR) and Platelet Lymphocyte Ratio (PLR) as common biomarkers that have been shown to have predictive value with colorectal cancer stage. This study aims to prove NHLR as a new biomarker that can predict advanced colorectal cancer in terms of staging and site of cancer compared to NLR and PLR. Methods: This is a retrospective cross-sectional study. Data obtained from the medical records of colorectal cancer patients undergoing surgery at Dr Sardjito Hospital from 2020 until 2022. Results: 386 patients enrolled in the study, and 62 patients met the inclusion criteria. Twentyeight patients (45.16 %) were male, and 34 (54.84 %) were female. The mean age is 58.82 years. Bivariate analysis showed a significant relationship between NHLR, NLR, and PLR with colorectal cancer stage and significant differences between NHLR and NLR with early and advanced colorectal cancer, but not with PLR. There are also significant differences between NHLR, NLR, and PLR with colorectal cancer sites in the colon and rectum. Still, in locally advanced stages of colorectal cancer, there is no significant association between NLR and cancer sites. On the contrary, there are significant differences between colon and rectal cancer sites with NHLR and PLR. Conclusions: NHLR is superior to NLR and PLR in predicting the stage and site of advanced colorectal cancer.

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Predictive Value of Preoperative Neutrophil-Lymphocyte and Platelet-Lymphocyte Ratio in Determining the Stage of Colon Tumors

Cited by 12 publications

References 21 publications

Diagnostic and prognostic value of the ratio of mean platelet volume to platelet count in acute mesenteric ischemia

Diagnostic and prognostic value of the ratio of mean platelet volume to platelet count in acute mesenteric ischemia

Does lymph node ratio (metastasis/total lymph node count) affect survival and prognosis in gastric cancer?

Neutrophil to Hemoglobin Lymphocyte Ratio (NHLR) as a Novel Biomarker is Superior to Neutrophil Lymphocyte Ratio (NLR) and Platelet Lymphocyte Ratio (PLR) as Predictors of Advanced Colorectal Cancer

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