Predictive value of semi-quantitative MRI-based scoring systems for future knee replacement: data from the osteoarthritis initiative

Hafezi-Nejad, Nima; Zikria, Bashir A.; Eng, John; Carrino, John A.; Demehri, Shadpour

doi:10.1007/s00256-015-2217-2

Cited by 33 publications

(25 citation statements)

References 38 publications

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“…Baseline BLOKS and WORMS cartilage scores were shown to predict TKR independently of total WOMAC scores and KLG. However, changes from baseline to 24 months follow-up in BLOKS and WORMS scores did not provide added predictive value 75 . Finally, knees with incident TKR displayed smaller baseline cartilage thickness and greater lateral femorotibial cartilage loss than matched non-TKR patients 76 .…”

Section: Prognosis/predictive Valuementioning

confidence: 88%

Osteoarthritis year in review 2016: imaging

Boesen

Ellegaard

Henriksen

et al. 2017

Osteoarthritis and Cartilage

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Section: Prognosis/predictive Valuementioning

confidence: 88%

Osteoarthritis year in review 2016: imaging

Boesen

Ellegaard

Henriksen

et al. 2017

Osteoarthritis and Cartilage

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“…Time in the study was defined by using the year of radiographic evaluation (for JSN progression) and using the days from the time of enrollment to the first KR or the last available follow-up visit (for subjects who did not undergo KR). Crude hazard ratios (HRs) and adjusted HRs were calculated, and stepwise adjustments were performed accordingly by considering other risk factors for OA progression and KR (age, sex, BMI, PASE score, WOMAC score, and KL grade) (16). To evaluate the progression of knee OA, the analysis was repeated by only including subjects with established OA at baseline (radiographic KL grade  2).…”

Section: Discussionmentioning

confidence: 99%

Meniscal Surgery: Risk of Radiographic Joint Space Narrowing Progression and Subsequent Knee Replacement—Data from the Osteoarthritis Initiative

et al. 2017

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Purpose To investigate the risk of radiographic joint space narrowing (JSN) progression evaluated in subjects with and those without underlying osteoarthritis at baseline and knee replacement (KR) associated with meniscal surgery in subjects with and those without a reported history of preceding knee trauma. Materials and Methods The HIPAA-compliant protocol was approved by the institutional review boards of the participating centers. Written informed consent was obtained from all participants. Subjects who underwent meniscal surgery with a preceding knee trauma at baseline (n = 564) and those without (n = 147) were drawn from the Osteoarthritis Initiative cohort (n = 4796). Radiographic JSN progression was evaluated by using Osteoarthritis Research Society International grading (progression in 1st-, 2nd-, 3rd-, 4th-, 6th-, or 8th-year radiographic findings compared with baseline). KR was assessed up to the 9th year of study (days passed from inclusion to KR or last follow-up). Cox hazard analysis was used to extract the adjusted hazard ratios (HRs) with adjustments for baseline age, sex, body mass index, physical activity, symptoms, and radiographic osteoarthritis features (Kellgren and Lawrence [KL] grade). Results Meniscal surgery with a history of preceding knee trauma was not associated with radiographic progression of JSN (adjusted HR, 0.91 [95% confidence interval {CI}: 0.78, 1.07]) or KR (adjusted HR, 1.02 [95% CI: 0.79, 1.34]; P = .854). However, meniscal surgery without a history of preceding knee trauma was associated with radiographic progression of JSN (adjusted HR, 1.27 [95% CI: 1.00, 1.63]) and KR (adjusted HR, 2.09 [95% CI: 1.52, 2.89]; P < .001). Additionally, there was a higher risk of KR in subjects with radiographic KL grade of less than 2 (adjusted HR, 6.97 [95% CI: 3.56, 13.64]; P < .001) at baseline in comparison with KL grade of at least 2 (adjusted HR, 1.76 [95% CI: 1.22, 2.54]; P < .05). Conclusion In contrast to subjects without a reported preceding trauma, meniscal surgery is not independently associated with increased risk of radiographic JSN progression and KR in patients with a reported preceding trauma. RSNA, 2016 Online supplemental material is available for this article.

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“…in differing opinions about the need for KR among individual orthopaedic surgeons, especially in younger patients (< 50 years old). In previously reported prediction models, clinical features, radiographic Kellgren-Lawrence (KL) grade, MRI features such as cartilage loss, Boston-Leeds Osteoarthritis Knee Score and unenhanced T2-weighted imaging of the infrapatellar fat pad were selected as the major risk factors of KR [9][10][11][12][13][14][15]. However, none of them was quantitative, as ordinal grading using the KL scale gave only a summary score of overall disease severity with varying intra-and inter-rater reliability [7].…”

Section: Electronic Supplementary Materialsmentioning

confidence: 99%

Predictive value of digital radiographic characteristics in combination with clinical evaluation scores in assessing the need for knee replacement

et al. 2019

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Objective To investigate the possibility of a combination of knee digital radiography (DR) characteristics and pain numerical rating scale (NRS) scores in predicting the need for knee replacement (KR). Materials and methods This follow-up study was approved by the local medical ethics review boards, and informed consent was obtained from the participants. Knee osteoarthritis (KOA) patients who underwent KR (n = 106; 90 females) and those who did not (n = 103; 78 females) along with normal controls (n = 104; 81 females) were followed up from December 2016 to March 2018. The minimum knee joint space width (MJSW) on radiographs, Kellgren-Lawrence (KL) grade, NRS scores, age at operation, and body weight were statistically analysed by binary logistic regression, ROC curves, and Kaplan-Meier analysis. Measurement reliability was assessed by using intraclass correlation coefficient (ICC) values. Results The results showed a high reliability (ICC > 0.98). NRS and MJSW showed a higher value for predicting KR (odds ratios 2.76 and 2.21, respectively). The combination of MJSW ≤ 2.08 mm and NRS score > 3.75 had better predictive value than either index alone. Conclusion The MJSW, an imaging characteristic derived from DR, and NRS scores have some predictive value for determining the need for KR in patients with KOA.

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Predictive value of semi-quantitative MRI-based scoring systems for future knee replacement: data from the osteoarthritis initiative

Cited by 33 publications

References 38 publications

Osteoarthritis year in review 2016: imaging

Osteoarthritis year in review 2016: imaging

Meniscal Surgery: Risk of Radiographic Joint Space Narrowing Progression and Subsequent Knee Replacement—Data from the Osteoarthritis Initiative

Predictive value of digital radiographic characteristics in combination with clinical evaluation scores in assessing the need for knee replacement

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