Predictive value of serum adiponectin and hemoglobin levels for vascular cognitive impairment in ischemic stroke patients

Li, Zhouling; Zhu, Manlian; Meng, C. I.; Lin, Hai; Huang, Lifen

doi:10.12669/pjms.38.3.5204

Cited by 3 publications

(3 citation statements)

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“…The proteins ARTN, HGF ( Gallo et al, 2015 ), and VEGF ( Lee et al, 2010 ) are associated with angiogenesis and neuroprotection, and their early predictive role in PSCI patients was identified ( Prodjohardjono et al, 2020 ; Hazelwood et al, 2022 ). Both neuroglobin and hemoglobin, which are subtypes of pearl proteins ( Lopez et al, 2010 ; Baez et al, 2016 ), play an important role in oxidative stress and protect brain tissue from hypoxic and ischemic damage, so their reduced levels increase the risk of developing PSCI ( Gao et al, 2022 ; Li Z. et al, 2022 ).…”

Section: Resultsmentioning

confidence: 99%

Post-stroke cognitive impairment: exploring molecular mechanisms and omics biomarkers for early identification and intervention

Lu,

Yu,

et al. 2024

Front. Mol. Neurosci.

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Post-stroke cognitive impairment (PSCI) is a major stroke consequence that has a severe impact on patients’ quality of life and survival rate. For this reason, it is especially crucial to identify and intervene early in high-risk groups during the acute phase of stroke. Currently, there are no reliable and efficient techniques for the early diagnosis, appropriate evaluation, or prognostication of PSCI. Instead, plenty of biomarkers in stroke patients have progressively been linked to cognitive impairment in recent years. High-throughput omics techniques that generate large amounts of data and process it to a high quality have been used to screen and identify biomarkers of PSCI in order to investigate the molecular mechanisms of the disease. These techniques include metabolomics, which explores dynamic changes in the organism, gut microbiomics, which studies host–microbe interactions, genomics, which elucidates deeper disease mechanisms, transcriptomics and proteomics, which describe gene expression and regulation. We looked through electronic databases like PubMed, the Cochrane Library, Embase, Web of Science, and common databases for each omics to find biomarkers that might be connected to the pathophysiology of PSCI. As all, we found 34 studies: 14 in the field of metabolomics, 5 in the field of gut microbiomics, 5 in the field of genomics, 4 in the field of transcriptomics, and 7 in the field of proteomics. We discovered that neuroinflammation, oxidative stress, and atherosclerosis may be the primary causes of PSCI development, and that metabolomics may play a role in the molecular mechanisms of PSCI. In this study, we summarized the existing issues across omics technologies and discuss the latest discoveries of PSCI biomarkers in the context of omics, with the goal of investigating the molecular causes of post-stroke cognitive impairment. We also discuss the potential therapeutic utility of omics platforms for PSCI mechanisms, diagnosis, and intervention in order to promote the area’s advancement towards precision PSCI treatment.

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Section: Resultsmentioning

confidence: 99%

Post-stroke cognitive impairment: exploring molecular mechanisms and omics biomarkers for early identification and intervention

Lu,

Yu,

et al. 2024

Front. Mol. Neurosci.

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“…As a main carrier of oxygen, hemoglobin level decreasing may result in oxygen deficiency in the body and lead to the hypoxic and ischemic injury of tissues and organs 3 . Previous researches have explored the relationships between hemoglobin and clinical outcomes in many disorders including cancer 4 , diabetes 5 , stroke 6 and trauma 7 .…”

Section: Introductionmentioning

confidence: 99%

Association between admission hemoglobin level and prognosis in sepsis patients based on a critical care database

Peng,

Su,

Luo

et al. 2024

Sci Rep

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This study aimed to explore the association between admission hemoglobin level and clinical outcomes in sepsis based on Medical Information Mart for Intensive Care IV(MIMIC-IV) database. It was a retrospective study. Sepsis patients in the database were included. Data extraction from MIMIC-IV was performed by PostgreSQL 9.6 software. Three different models including crude model (adjusted for none), model I (adjusted for gender and age) and model II (adjusted for all potential cofounders) were constructed. A generalized liner model and a smooth fitting curve for indicating the relationship between hemoglobin level and 30-day mortality were performed. 6249 septic patients with a 30.18% of 30-day mortality were included. With 1 g/dl increment in hemoglobin level, the values of odds ratio (OR) in crude model, model I and model II were 0.96 (95% confidential interval (CI) 0.94–0.99, P = 0.0023), 0.96 (95%CI 0.93–0.98, P = 0.0010) and 0.87 (95%CI 0.79–0.95, P = 0.0020), respectively. The smooth fitting curve indicated a non-linear relationship and the turning point was 7.2 g/dl. Compared the hemoglobin group < 7.2 g/dl, the risk of 30-day mortality significantly decreased by 32% in the hemoglobin group ≥ 7.2 g/dl (OR = 0.68, 95%CI 0.51–0.93, P = 0.0142). The non-linear relationship between admission hemoglobin level and 30-day mortality in sepsis was found. Hemoglobin supplementation might be beneficial for septic patients with hemoglobin level < 7.2 g/dl.

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“…Stroke survivors are prone to cognitive impairment and at high risk of dementia; however, the exact cause remains unknown. 2 Without any specific remedy or treatment protocol, it is of great importance to prevent the occurrence of cognitive impairment or dementia and treat the affected group with combination therapy. 3 Oxiracetam (OXR) represents an emerging kind of nootropics with claimed benefits to improve dysmnesia, repair damaged nerve cells, protect brain tissue from hypoxia, and enhance learning, while its efficacy requires corroboration.…”

Section: Introductionmentioning

confidence: 99%

Efficacy and association of hyperbaric oxygen therapy combined with butylphthalide and oxiracetam with serum levels of inflammatory markers in vascular cognitive impairment after acute ischemic stroke

Dong¹,

Wu²,

2023

Pak J Med Sci

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Objectives: This study evaluated the efficacy of hyperbaric oxygen therapy (HBOT) combined with butylphthalide (NBP) and oxiracetam (OXR) for vascular cognitive impairment after acute ischemic stroke and investigated the association between such combination therapy and the serum levels of inflammatory markers. Methods: This was a prospective study which included eighty patients with post-AIS cognitive impairment (PAISCI) treated in Dongguan City People’s Hospital from January 2020 to January 2022. They were randomized into study group and control group. The control group was provided with conventional therapy consisting of NBP for intravenous transfusion and oral OXR, while the study group received combination therapy of HBOT, NBP, and OXR. A comparison was drawn between the two groups regarding clinical outcomes, levels of recovery of cognitive and neurological function and intelligence, changes in inflammatory markers, and incidence of adverse drug reactions (ADRs). Results: The response rate of the study group was significantly higher than that of the control group (p=0.04). The cognitive function scores of the study group were significantly better than those of the control group at the end of treatment (p<0.05). The post-treatment levels of inflammatory markers were significantly reduced in the study group when compared with the control group (p<0.05). At two weeks after treatment, the ADR rate of study group was significantly lower than the control group (p=0.03). Conclusions: The combination therapy of HBOT, NBP, and OXR demonstrates robust efficacy in patients with PAISCI. It is deemed to be a safe and effective treatment regimen. doi: https://doi.org/10.12669/pjms.39.3.6828 How to cite this: Dong Q, Wu M, Hu W. Efficacy and association of hyperbaric oxygen therapy combined with butylphthalide and oxiracetam with serum levels of inflammatory markers in vascular cognitive impairment after acute ischemic stroke. Pak J Med Sci. 2023;39(3):829-834. doi: https://doi.org/10.12669/pjms.39.3.6828 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Predictive value of serum adiponectin and hemoglobin levels for vascular cognitive impairment in ischemic stroke patients

Cited by 3 publications

References 32 publications

Post-stroke cognitive impairment: exploring molecular mechanisms and omics biomarkers for early identification and intervention

Post-stroke cognitive impairment: exploring molecular mechanisms and omics biomarkers for early identification and intervention

Association between admission hemoglobin level and prognosis in sepsis patients based on a critical care database

Efficacy and association of hyperbaric oxygen therapy combined with butylphthalide and oxiracetam with serum levels of inflammatory markers in vascular cognitive impairment after acute ischemic stroke

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