Predictive value of serum YKL-40 for major adverse cardiovascular events within 30 days after PCI for acute ST-segment elevation myocardial infarction

Abstract

Background This study aimed to investigate the predictive value of serum YKL-40 for major adverse cardiovascular events within 30 days after PCI for acute ST-segment elevation myocardial infarction (STEMI). Methods In this study, 120 patients with STEMI admitted to the Second People's Hospital of Hefei from October 2020 to February 2022 were included. All patients received cubital venous blood sampling before PCI to detect serum YKL-40 concentration. Patients were followed up for 30 days after PCI and divided into the MACE group (n = 27) and Non-MACE group (n = 93) according to whether MACE occurred. Univariate and multivariate Cox regression analysis was used to analyze the effect of serum YKL-40 on MACE within 30 days after PCI in STEMI patients. The predictive value of serum YKL-40 for the occurrence of MACE within 30 days after PCI in patients with STEMI was assessed by plotting receiver operating characteristic (ROC) curves. Kaplan-Meier method was used to plot the survival curve of MACE occurring 30 days after PCI in STEMI patients. Results Serum YKL-40 levels were higher in patients in the MACE group than in patients in the Non-MACE group (1431.08±445.31 vs 1028.28±558.47 ng/dL, P < 0.05); Multivariate Cox regression analysis showed that serum YKL-40 was an independent risk factor for MACE events within 30 days after PCI in STEMI patients (OR = 1.002, 95% CI 1.001 – 1.002, P = 0.003); ROC curve analysis showed that the area under the curve (AUC) of serum YKL-40 was 0.768, the sensitivity was 0.741, the specificity was 0.763, and the optimal cutoff value was 1383.91 ng/dL in predicting the risk of MACE events within 30 days after PCI in STEMI patients; Kaplan-Meier survival curve analysis showed that the MACE-free survival rate at 30 days after PCI decreased with increasing serum YKL-40 levels in STEMI patients (Log-Rank P = 0.011). Conclusions Serum YKL-40 is associated with short-term prognosis in patients with STEMI. High serum YKL-40 levels can be used as a predictor of MACE within 30 days after PCI in STEMI patients.

Association of CHA2DS2-VASC Score with in-Hospital Cardiovascular Adverse Events in Patients with Acute ST-Segment Elevation Myocardial Infarction

“…A preprint has previously been published [Cao Yang Fang Zhenfei Chen et al 2022] [ 27 ]. Previously Published Articles [ 28 ].…”