Predictive value of the eosinophil counts in the biological diagnosis of lymphatic filariasis in French Polynesia

Musso, Didier; Vialette, V.

doi:10.1016/j.medmal.2012.09.006

Cited by 3 publications

(1 citation statement)

References 18 publications

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“…Lymphatic filariasis is typically associated with an eosinophilia; blood eosinophil count may be used as a nonspecific screening tool in endemic areas. 32 …”

Section: Peripheral Blood Filmsmentioning

confidence: 99%

The Utility of Blood and Bone Marrow Films and Trephine Biopsy Sections in the Diagnosis of Parasitic Infections

Miller¹,

Bain²

2015

Mediterr J Hematol Infect Dis

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The laboratory haematologist has a role in the diagnosis of parasitic infections. Peripheral blood examination is critical in the diagnosis of malaria, babesiosis, filariasis and trypanosomiasis. Bone marrow examination is important in the diagnosis of leishmaniasis and occasionally leads to the diagnosis of other parasitic infections. The detection of eosinophilia or iron deficiency anaemia can alert the laboratory haematologist or physician to the possibility of parasitic infection. In addition to morphological skills, an adequate clinical history is important for speedy and accurate diagnosis, particularly in non-endemic areas.

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“…Lymphatic filariasis is typically associated with an eosinophilia; blood eosinophil count may be used as a nonspecific screening tool in endemic areas. 32 …”

Section: Peripheral Blood Filmsmentioning

confidence: 99%

The Utility of Blood and Bone Marrow Films and Trephine Biopsy Sections in the Diagnosis of Parasitic Infections

Miller¹,

Bain²

2015

Mediterr J Hematol Infect Dis

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Lymphatic Filariasis in Oceania

Graves

Bossin

2016

Neglected Tropical Diseases

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Morphological Spectrum of Bone Marrow Aspirates in Infections: A Clinico-Hematological Analysis

Aggarwal,

More,

Singh

et al. 2023

Journal of Microscopy and Ultrastructure

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Context: Bone marrow examination (BME) is an invaluable tool for cases with pyrexia of unknown origin and pancytopenia. However, it is under-utilized for diagnosing infectious etiology and there is a paucity of literature regarding its role in infective pathology. Aims: This study aims to bring to light the role of BME in diagnosing infectious pathology. Settings and Design: A retrospective study was carried out on bone marrow aspirates (BMAs) sent to the hematology department over the past 4 years. Clinical details, peripheral smears and BMA were retrieved from the records and analyzed. Subjects and Methods: Leishman-stained peripheral smears and BMA were studied along with bone marrow biopsy wherever feasible. Results: A total of 52 cases were studied. The most common clinical presentation was fever, clinical finding was splenomegaly and hematological finding was anemia. Based on the morphological findings in combination with clinical history, cases were categorized into–parasitic (26.9%), viral (23.1%), tubercular (11.5%), and nonspecific infections (38.5%). Parasites such as Leishmania donovani, microfilaria, plasmodium falciparum, and vivax were reported in 14/52 (27%) cases. Associated BMA findings were plasmacytosis, eosinophilia, reactive lymphocytosis, or dyserythopoiesis. In 38% (20/52) cases, no specific cause of infection was found in the bone marrow. These patients showed histiocytosis, hemophagocytosis, maturation arrest in myeloid lineage, relative myeloid hyperplasia, dysmyelopoiesis, toxic granulation/vacuolation in myeloid cells, lymphocytosis, increased plasma cells or monocytosis in marrow. Conclusions: Increased histiocytes, hemophagocytosis, dysplastic changes, maturation arrest, relative myeloid hyperplasia or reactive plasmacytosis, lymphocytosis, and monocytosis are BMA features which must alert the pathologist towards an infectious disease process, a knowledge of these changes can help extend the scope of BME beyond hemato-lymphoid malignancies.

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Predictive value of the eosinophil counts in the biological diagnosis of lymphatic filariasis in French Polynesia

Cited by 3 publications

References 18 publications

The Utility of Blood and Bone Marrow Films and Trephine Biopsy Sections in the Diagnosis of Parasitic Infections

The Utility of Blood and Bone Marrow Films and Trephine Biopsy Sections in the Diagnosis of Parasitic Infections

Lymphatic Filariasis in Oceania

Morphological Spectrum of Bone Marrow Aspirates in Infections: A Clinico-Hematological Analysis

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