Predictive value of the Naples prognostic score on postoperative outcomes in patients with rectal cancer

Sugimoto, Atsushi; Fukuoka, Tatsunari; Nagahara, Hisashi; Shibutani, Masatsune; Iseki, Yasuhito; Kasashima, Hiroaki; Sasaki, Maho; Ohira, Masaichi; Maeda, Kiyoshi

doi:10.1007/s00423-023-02851-2

Cited by 5 publications

(3 citation statements)

References 33 publications

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“…Several studies showed that systemic inflammation is effective in demonstrating postoperative complications. Sugimoto et al reported that Naples prognostic score, which developed from inflammatory biomarkers, was an independent predictive marker for severe postoperative complications [ 29 ]. Tong et al showed that increased NLR and serum eotaxin-2 levels were strongly related to postoperative complications [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Should we consider Systemic Inflammatory Response Index (SIRI) as a new diagnostic marker for rectal cancer?

Yazici,

Eren Kayaci,

Sevindi

et al. 2024

Discov Onc

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Purpose The Systemic Inflammatory Response Index (SIRI), which depends on peripheral neutrophil, monocyte, and lymphocyte count, was found to be an effective prognostic indicator for various malignancies. In this study, we aimed to investigate the diagnostic value and the prognostic impact of SIRI on rectal cancer patients. Method The medical records of patients underwent sphincter-sparing rectal cancer surgery at general surgery between 2017 and 2022 were examined retrospectively. Patient demographics, operation types, neoadjuvant chemo/radiotherapies, pathological results, and complications were recorded. A total number of 99 patients who operated with diagnoses other than cancer were conducted as a control group. SIRI was calculated from preoperative peripheral blood samples’ neutrophil, lymphocyte, and monocyte count. The optimal cut-off value for SIRI was found to be 1.38. The clinicopathological outcomes and Overall Survival (OS) were analyzed under two groups according to the SIRI values lower or higher than 1.38. Results The number of eligible patients was 104. The median age of the entire cohort was 62 (31–89). The median follow-up time was 33 (1–62) months. The median SIRI value in the study group was significantly higher compared with the control group. The study group was examined under two groups: SIRI 1.38 and SIRI > 1.38. The male gender was significantly more frequent in the high SIRI group. The remaining patient demographics and operation types were similar between the groups. The pathological outcomes were similar between the two groups. Overall Survival rate was better in the low SIRI group than those higher. The higher group had significantly higher complication rates than the lower SIRI group (p: 0.004). Conclusion SIRI may be a valuable diagnostic marker in rectal cancer patients. Higher SIRI levels were also associated with poorer prognosis and increased complication rates. Still, further prospective studies with a larger number of patients are needed.

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Section: Discussionmentioning

confidence: 99%

Should we consider Systemic Inflammatory Response Index (SIRI) as a new diagnostic marker for rectal cancer?

Yazici,

Eren Kayaci,

Sevindi

et al. 2024

Discov Onc

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“…In recent years, some articles had confirmed the connection between preoperative NPS and short-term and long-term complications in the elderly with GC and CRC [ 9 , 42 ]. Also, a recent review noted that POD was the most common serious postoperative complication in the older individuals, with uncertain aetiology, limited preventative strategies, and poor long-term outcomes [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

Predictive value of the Naples prognostic score on postoperative delirium in the elderly with gastrointestinal tumors: a retrospective cohort study

Song,

Yu,

et al. 2024

BMC Geriatr

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Background Postoperative delirium (POD) is a common complication among elderly patients after surgery. The Naples Prognostic Score (NPS), a novel prognostic marker based on immune-inflammatory and nutritional status, was widely used in the assessment of the prognosis of surgical patients. However, no study has evaluated the relationship between NPS and POD. The aim of this article was to investigate the association between NPS and POD and test the predictive efficacy of preoperative NPS for POD in elderly patients with gastrointestinal tumors. Materials and methods In the present study, we retrospectively collected perioperative data of 176 patients (≥ 60 years) who underwent elective gastrointestinal tumor surgery from June 2022 to September 2023. POD was defined according to the chart-based method and the NPS was calculated for each patient. We compared all the demographics and laboratory data between POD and non-POD groups. Univariate and multivariate logistic regression analysis was used to explore risk factors of POD. Moreover, the accuracy of NPS in predicting POD was further assessed by utilizing receiver operating characteristic (ROC) curves. Results 20 had POD (11.4%) in a total of 176 patients, with a median age of 71 (65–76). The outcomes by univariate analysis pointed out that age, ASA status ≥ 3, creatinine, white blood cell count, fasting blood glucose (FBG), and NPS were associated with the risk of POD. Multivariate logistic regression analysis further showed that age, ASA grade ≥ 3, FBG and NPS were independent risk factors of POD. Additionally, the ROC curves revealed that NPS allowed better prognostic capacity for POD than other variables with the largest area under the curve (AUC) of 0.798, sensitivity of 0.800 and specificity of 0.667, respectively. Conclusion Age, ASA grade ≥ 3, and FBG were independent risk factors for POD in the elderly underwent gastrointestinal tumor surgery. Notably, the preoperative NPS was a more effective tool in predicting the incidence of POD, but prospective trials were still needed to further validate our conclusion. Trial registration The registration information for the experiment was shown below. (date: 3rd January 2024; number: ChiCTR2400079459)

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“…four altered values were assigned a score of 2. Four studies evaluated the clinical impact of the NPS in patients with CRC (TableV)(117)(118)(119)(120). All studies evaluated patients in the surgical setting.…”

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Clinical Impact of Nutrition and Inflammation Assessment Tools in Colorectal Cancer Treatment

AOYAMA,

YUKAWA,

SAITO

2024

Anticancer Res

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For resectable colorectal cancer (CRC), the standard treatment is perioperative adjuvant treatment and complete resection. For unresectable CRC, the standard treatment is systemic chemotherapy. The detection of promising biomarkers is necessary for optimizing the management of CRC and improving patient survival. If physicians can detect useful biomarkers, patients with CRC may benefit from more aggressive or less toxic treatment. Recent studies have shown that the inflammatory and nutritional status both influence the short and long-term oncological outcomes of patients with CRC during perioperative and/or chemotherapy. The utility of several tools for the evaluation of the inflammation and nutritional status has been reported. The introduction of such tools in the management of CRC could have a beneficial impact on postoperative surgical complications or adverse events of chemotherapy. An understanding of the characteristics of each of these evaluations is necessary for their introduction in daily clinical practice. The present report summarizes the background and current status of nutrition and inflammation evaluation tools and future perspectives on their application in the management of patients with CRC.Colorectal cancer (CRC) is the third most common cancer and the second leading cause of cancer-related deaths worldwide (1, 2). Curative resection and perioperative adjuvant treatment are standard treatments for resectable CRC, while chemotherapy is the standard treatment for unresectable CRC (3, 4). The prognosis of CRC is gradually improving, and the survival of more than half of patients with CRC is limited and poor after diagnosis. Therefore, CRC patients with risk factors for recurrence require more aggressive treatment and management.Recently, the nutritional and inflammatory status during treatment has been recognized as an important factor for both short-and long-term oncological outcomes in various malignancies (5-7). So far, various nutritional and inflammation assessment tools, such as the Glasgow Prognostic Score (GPS), Prognostic Nutritional Index (PNI), Controlling Nutritional Status (CONUT score), C-reactive protein Albumin ratio (CAR), and Albumin/Globulin Ratio (AGR), have been developed and evaluated in gastrointestinal cancers, including CRC. If physicians introduce these nutritional and inflammation assessment tools in daily clinical practice, CRC patients may be able to receive optimized treatments that are more aggressive in comparison to standard treatment. However, each nutritional and inflammatory evaluation tool has its own clinical characteristics. Therefore, physicians need to understand the characteristics of each nutritional and inflammation evaluation tool before their introduction into daily clinical practice.This review summarizes the background, current status, and future perspectives of nutritional and inflammatory assessment tools for CRC treatment. Clinical Impact of the Glasgow Prognostic Score (GPS) for CRC TreatmentThe Glasgow Prognostic Score (GPS) was first reported b...

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Predictive value of the Naples prognostic score on postoperative outcomes in patients with rectal cancer

Cited by 5 publications

References 33 publications

Should we consider Systemic Inflammatory Response Index (SIRI) as a new diagnostic marker for rectal cancer?

Should we consider Systemic Inflammatory Response Index (SIRI) as a new diagnostic marker for rectal cancer?

Predictive value of the Naples prognostic score on postoperative delirium in the elderly with gastrointestinal tumors: a retrospective cohort study

Clinical Impact of Nutrition and Inflammation Assessment Tools in Colorectal Cancer Treatment

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