2012
DOI: 10.1111/j.1442-9071.2012.02780.x
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Predictive value of the vitamin K epoxide reductase complex subunit 1 G‐1639A and C1173T single nucleotide polymorphisms in retinal vein occlusion

Abstract: It was found that subjects with the vitamin K epoxide reductase complex subunit 1 GG and CC genotypes had a higher risk of retinal vein occlusion.

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Cited by 10 publications
(7 citation statements)
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“…% 21; P=0.021). Çok değişkenli lojistik regresyon analizleri sonrasında da VKORC1 GG ve CC genotipleri daha fazla RVT riskine sahipti [3]. Bilindiği gibi vitamin-K bağımlı proteinler olan faktör-2, faktör-7, faktör-9 ve faktör-10 koagülasyon sü-recinde önemli fonksiyonlara sahiptir [4].…”
Section: Discussionunclassified
“…% 21; P=0.021). Çok değişkenli lojistik regresyon analizleri sonrasında da VKORC1 GG ve CC genotipleri daha fazla RVT riskine sahipti [3]. Bilindiği gibi vitamin-K bağımlı proteinler olan faktör-2, faktör-7, faktör-9 ve faktör-10 koagülasyon sü-recinde önemli fonksiyonlara sahiptir [4].…”
Section: Discussionunclassified
“…Обнаружено, что генотип GG по полиморфно-му маркеру G1639A гена vKoRc1 чаще встреча-ется в группе пациентов, перенёсших окклюзию вен сетчатки, что не противоречит ранее опубли-кованным данным зарубежных коллег [12,13]. Аналогичные результаты генотипирования были получены и у лиц с АОСС, однако из-за неболь-шого количества наблюдений эти данные были статистически недостоверны.…”
Section: заключениеunclassified
“…It occurs as a result of intraluminal thrombus formation and is associated with hypertension, hyperlipidemia, diabetes, smoking, oral contraceptive use and hypercoagulable states 105 . To explore whether genetic polymorphisms in the coagulation pathway are associated with RVO risk, a candidate gene study was recently conducted in a Turkish population 106 . There was a significant association between the VKORC1 –1639G>A and VKORC1 -1173 C>T polymorphisms and risk for RVO.…”
Section: Retinal Vascular Diseasementioning
confidence: 99%