Predictive value of traditional risk factors for cardiovascular disease in older people: A systematic review

Bussel, Emma F. van; Hoevenaar‐Blom, Marieke P.; Poortvliet, Rosalinde K.E.; Gussekloo, Jacobijn; Dalen, Jan Willem van; Gool, Willem A. van; Richard, Edo; Charante, Eric P. Moll van

doi:10.1016/j.ypmed.2020.105986

Cited by 44 publications

(37 citation statements)

References 53 publications

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“…A maior média de idade observada no grupo hipertenso reflete os índices encontrados na população em geral, em que se constata tendência de aumento de HAS nas maiores faixas etárias e elevada incidência entre os idosos (25) . Pesquisadores referenciam que, aproximadamente, 65% dos idosos em todo o mundo são hipertensos, mas fazem um alerta para que o aumento de pressão relacionado à idade não seja considerado uma condição fisiológica (26) .…”

Section: Discussionunclassified

“…As pessoas insuficientemente ativas aumentam em 20% e 30% o risco de mortalidade (25) . Estima-se que 3,2 milhões de pessoas morrem a cada ano devido à inatividade física (29) .…”

Section: Discussionunclassified

“…Estudo de metanálise (35) observou que indivíduos diabéticos apresentam risco três a quatro vezes maior de sofrer um evento cardiovascular e o dobro do risco de morrer desse evento em comparação à população geral. Esse aumento na prevalência de glicemia em jejum alterada é comparável ao que vem sendo observado em alguns países (2)(3)(4)(5)(6)25) .…”

Section: Estudos Epidemiológicos Como Nurses' Health Study Nhanes unclassified

“…Com base nos achados, a obesidade abdominal, por meio da medida de circunferência abdominal, foi considerada elevada, atendendo ao critério de ponto de corte para homens (102 cm) e mulheres (88 cm). Esse achado confirma que a medida da CA é importante para a utilização como indicador de RCV, e pode ser acrescentada como uma rotina clínica e nas unidades de saúde, como exame para avaliação do RCV, corroborando com outros estudos publicados na literatura (24)(25)(26)37) .…”

Section: Estudos Epidemiológicos Como Nurses' Health Study Nhanes unclassified

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Risco cardiovascular em hipertensos cadastrados em uma unidade de saúde no Norte do Brasil

Haito

Moreira

Freitas

et al. 2020

RBPS

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Este artigo está publicado em acesso aberto (Open Access) sob a licença Creative Commons, que permite uso, distribuição e reprodução em qualquer meio, sem restrições, desde que o trabalho seja corretamente citado. Risco cardiovascular em hipertensos cadastrados em uma unidade de saúde no Norte do Brasil Cardiovascular risk in hypertensive patients registered in a health unit in Northern Brazil Riesgo cardiovascular de pacientes con hipertensión registrados en una unidad de salud en el norte de Brasil

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Section: Discussionunclassified

“…As pessoas insuficientemente ativas aumentam em 20% e 30% o risco de mortalidade (25) . Estima-se que 3,2 milhões de pessoas morrem a cada ano devido à inatividade física (29) .…”

Section: Discussionunclassified

Section: Estudos Epidemiológicos Como Nurses' Health Study Nhanes unclassified

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Risco cardiovascular em hipertensos cadastrados em uma unidade de saúde no Norte do Brasil

Haito

Moreira

Freitas

et al. 2020

RBPS

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“…The understanding of CVD risk factors is quite important to establish the cardiovascular risk prediction models. The age, gender, body mass index (BMI), systolic blood pressure (SBP), diabetes mellitus, smoking, total cholesterol levels, and past cardiovascular events are established and traditional risk factors in middle-aged and older individuals [2].…”

Section: Introductionmentioning

confidence: 99%

Novel Urinary Glycan Biomarkers Predict Cardiovascular Events in Patients with Type 2 Diabetes: A Multicenter Prospective Study with 5-year Follow up (U-CARE Study 2)

Mise

Imamura

Yamaguchi

et al. 2021

Preprint

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BackgroundAlthough various biomarkers predict cardiovascular event (CVE) in patients with diabetes, the relationship of urinary glycan profile with CVE in patients with diabetes remains unclear.MethodsAmong 680 patients with type 2 diabetes, we examined the baseline urinary glycan signals binding to 45 lectins with different specificities. Primary outcome was defined as cardiovascular event including cardiovascular disease, stroke, and peripheral arterial disease.ResultsDuring approximately 5-year follow-up period, 62 patients reached the endpoint. Cox proportional hazards analysis revealed that urinary glycan signals binding to two lectins were significantly associated with the outcome after adjustment for known indicators of CVE and for false discovery rate, as well as increased model fitness. Hazard ratios for these lectins (+ 1 SD for the glycan index) were: UDA (recognizing glycan: mixture of Man5 to Man9): 1.78 (95% CI: 1.24–2.55, P = 0.002) and Calsepa (High-Man [Man2-6]): 1.56 (1.19–2.04, P = 0.001). Common glycan binding to these lectins was high-mannose type of N-glycans. Moreover, adding glycan index for UDA to a model including known factors of CVE improved the outcome prediction (Difference of Harrel’s C-index: 0.028 [95% CI: 0.001–0.055, P = 0.044], net reclassification improvement at 5-year risk increased by 0.368 [0.045–0.692, P = 0.026], and the Akaike information criterion and Bayesian information criterion decreased from 725.7 to 716.5, and 761.8 to 757.2, respectively).ConclusionsThe urinary excretion of high-mannose glycan may be a valuable marker for predicting CVE in patients with type 2 diabetes, which provide the rationale to explore the mechanism underlying abnormal N-glycosylation in CVE of patients with diabetes.Trial registrationThis study was registered with the University Hospital Medical Information Network in June 26th 2012 (Clinical trial number: UMIN000011525, URL: https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000013482).

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Impact of cardiac history and myocardial scar on increase of myocardial perfusion after revascularization

Jukema

Winter

Hopman

et al. 2023

Eur J Nucl Med Mol Imaging

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Purpose We sought to assess the impact of coronary revascularization on myocardial perfusion and fractional flow reserve (FFR) in patients without a cardiac history, with prior myocardial infarction (MI) or non-MI percutaneous coronary intervention (PCI). Furthermore, we studied the impact of scar tissue. Methods Symptomatic patients underwent [15O]H2O positron emission tomography (PET) and FFR before and after revascularization. Patients with prior CAD, defined as prior MI or PCI, underwent scar quantification by magnetic resonance imaging late gadolinium enhancement. Results Among 137 patients (87% male, age 62.2 ± 9.5 years) 84 (61%) had a prior MI or PCI. The increase in FFR and hyperemic myocardial blood flow (hMBF) was less in patients with prior MI or non-MI PCI compared to those without a cardiac history (FFR: 0.23 ± 0.14 vs. 0.20 ± 0.12 vs. 0.31 ± 0.18, p = 0.02; hMBF: 0.54 ± 0.75 vs. 0.62 ± 0.97 vs. 0.91 ± 0.96 ml/min/g, p = 0.04). Post-revascularization FFR and hMBF were similar across patients without a cardiac history or with prior MI or non-MI PCI. An increase in FFR was strongly associated to hMBF increase in patients without a cardiac history or with prior MI/non-MI PCI (r = 0.60 and r = 0.60, p < 0.01 for both). Similar results were found for coronary flow reserve. In patients with prior MI scar was negatively correlated to hMBF increase and independently predictive of an attenuated CFR increase. Conclusions Post revascularization FFR and perfusion were similar among patients without a cardiac history, with prior MI or non-MI PCI. In patients with prior MI scar burden was associated to an attenuated perfusion increase.

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Predictive value of traditional risk factors for cardiovascular disease in older people: A systematic review

Cited by 44 publications

References 53 publications

Risco cardiovascular em hipertensos cadastrados em uma unidade de saúde no Norte do Brasil

Risco cardiovascular em hipertensos cadastrados em uma unidade de saúde no Norte do Brasil

Novel Urinary Glycan Biomarkers Predict Cardiovascular Events in Patients with Type 2 Diabetes: A Multicenter Prospective Study with 5-year Follow up (U-CARE Study 2)

Impact of cardiac history and myocardial scar on increase of myocardial perfusion after revascularization

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