Predictive value of uric acid/albumin ratio for the prediction of new-onset atrial fibrillation in patients with ST-Elevation myocardial infarction

Abstract

Background: There is a lack of studies supporting the association between the uric acid/albumin ratio (UAR) and the development of new-onset atrial fibrillation (NOAF) in ST-elevation myocardial infarction (STEMI) patients treated with primary percutaneous coronary intervention (pPCI). Objective: The objective of the study was to assess the efficacy of the UAR for predicting the occurrence of NOAF in STEMI patients undergoing pPCI. Methods: We recruited 1484 consecutive STEMI patients in this retrospective and cross-sectional investigation. The population sample was classified based on the development of NOAF during hospitalization. NOAF was defined as an atrial fibrillation (AF) observed during hospitalization in patients without a history of AF or atrial flutter. The UAR was computed by dividing the serum uric acid (UA) level by serum albumin level.Results: After pPCI, 119 STEMI patients (8%) were diagnosed with NOAF. NOAF patients had higher serum UAR levels than individuals who did not have NOAF. According to the multivariable logistic regression model, the UAR was an independent predictor for NOAF in STEMI patients (OR: 6.951, 95% CI: 2.978-16.28, p < 0.001). The area under curve (AUC) value of the UAR in a receiver operating characteristics (ROC) evaluation was 0.758, which was greater than those of its components (albumin [AUC: 0.633] and UA [AUC: 0.647]) and C-reactive protein (AUC: 0.714). The optimal UAR value in predicting NOAF in STEMI patients was greater than 1.39, with a sensitivity of 69% and a specificity of 74.5%. Conclusion: To the best of our knowledge, this is the first study indicating that the UAR was an independent predictor of NOAF development in STEMI patients.

Elevated uric acid/albumin ratio as a predictor of poor coronary collateral circulation development in patients with non‐ST segment elevation myocardial infarction

“…39 The UAR index was associated with the occurrence of atrial fibrillation and kidney injury. 40,41 Furthermore, Toprak et al 15 and Şaylık et al 16…”

“… 39 The UAR index was associated with the occurrence of atrial fibrillation and kidney injury. 40 , 41 Furthermore, Toprak et al 15 and Şaylık et al 16 have found that UAR was a superior marker in predicting poorly‐developed CCC in stable coronary heart disease. However, the relationship between the UAR and CCC development in NSTEMI patients remains poorly understood.…”

Relationship between uric acid to albumin ratio and in-stent restenosis in patients with coronary artery disease undergoing drug-eluting stenting

“…Consequently, individuals with higher UAR values might exhibit increased susceptibility to inflammation, oxidative stress, and severe CAD compared with those with lower UAR values. Recent research has supported this idea and recognized UAR as a novel marker for inflammation and oxidative stress, which exhibits a robust correlation with cardiovascular disorders [ 11 , 13 ].…”

“…The uric acid-albumin ratio (UAR) – an innovative inflammatory and oxidative stress metric that combines UA and albumin measurements to reflect the body’s overall inflammatory and oxidative status – reportedly correlates with adverse cardiovascular prognostic events [ 11 – 13 ] and the severity of CAD [ 14 , 15 ]. However, no research has explored the association between UAR and the occurrence of ISR in individuals who undergo DES placement.…”

The association between systemic inflammatory response index and new-onset atrial fibrillation in patients with ST-elevated myocardial infarction treated with percutaneous coronary intervention

“…Additionally, a retrospective analysis of 402 STEMI individuals treated with PCI had demonstrated that SII can independently predict NOAF [ 31 ]. A retrospective and cross-sectional investigation of 1484 STEMI individuals following PCI conducted by Selçuk et al had displayed that the value of uric acid/albumin can independently predict the development of NOAF [ 32 ]. Another recent investigation concluded that SII is an independent predictor of postoperative AF after analyzing 391 consecutive cases treated with isolated coronary artery bypass grafting and also demonstrated that the predictive role of SII is superior to that of NLR or platelet to lymphocyte ratio[ 33 ].…”