Predictive Value of Xrcc1 Gene Polymorphisms for Side Effects in Patients undergoing Whole Breast Radiotherapy: a Meta-analysis

Xie, Xiaoxue; Ouyang, Shuyu; Jin, He; Wang, Hui; Zhou, Jinsong; Hu, Bingqiang

doi:10.7314/apjcp.2012.13.12.6121

Cited by 9 publications

(11 citation statements)

References 38 publications

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“…Treatment-related factors include total RT dose, RT fraction size, RT technique, volume of skin irradiated, and addition of adjuvant chemotherapy. Patient-related factors include breast size, smoking history, diabetes mellitus, and BMI (Tucker et al, 1992;Fernando et al, 1996;Fisher et al, 2000;Pommier et al, 2004;Xie et al, 2012). In our study, total RT dose and lymph nodal irradiation were significant prognostic factors for radiation dermatitis.…”

Section: Discussionmentioning

confidence: 52%

Topical Use of Recombinant Human Epidermal Growth Factor (EGF)-Based Cream to Prevent Radiation Dermatitis in Breast Cancer Patients: a Single-Blind Randomized Preliminary Study

Kong¹,

Hong²

2013

Asian Pacific Journal of Cancer Prevention

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Background: The purpose of this study was to assess the effectiveness of a recombinant human epidermal growth factor (EGF)-based cream for the prevention of acute radiation dermatitis in breast cancer patients receiving radiotherapy (RT). Materials and Methods: Between December 2012 and April 2013, 40 breast cancer patients who received postoperative RT were prospectively enrolled in this study and randomly assigned to receive human recombinant EGF-based cream (intervention group) or general supportive skin care (control group). The grade of radiation dermatitis and pain score were examined at weekly intervals during RT and 6 weeks after RT completion. Results: All patients completed the planned RT and complied well with instructions for applying the study cream and general supportive skin care. In the intervention group, radiation dermatitis of maximum grade 3, 2, and 1 developed in 3 (15%), 11 (55%), and 6 patients (30%), respectively. In comparison, in the control group, radiation dermatitis of maximum grade 3, 2, and 1 developed in 8 (40%), 10 (50%), and 2 patients (10%), respectively. The intervention group showed lower incidence of grade 3 radiation dermatitis than the control group (p=0.068 in univariate analysis and p=0.035 in multivariate analysis). There was no statistically significant difference in the maximal pain score between the two groups (p=0.934). Conclusions: This single-blind randomized preliminary study showed that recombinant human EGF-based cream can have a beneficial role in preventing or minimizing radiation dermatitis in breast cancer patients. To confirm the results of our study, additional studies with a large sample size are required.

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Section: Discussionmentioning

confidence: 52%

Topical Use of Recombinant Human Epidermal Growth Factor (EGF)-Based Cream to Prevent Radiation Dermatitis in Breast Cancer Patients: a Single-Blind Randomized Preliminary Study

Kong¹,

Hong²

2013

Asian Pacific Journal of Cancer Prevention

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“…In a recent meta-analysis [28], the predictive value of XRCC1 SNPs for side effects in patients undergoing whole breast radiotherapy has been determined. 11 studies mainly comprising Caucasian patients, addressing both acute and late toxicity, were included in the analysis.…”

Section: Discussionmentioning

confidence: 99%

Polymorphisms in X-Ray Repair Cross-Complementing Group 1 Gene: Haplotypes, Breast Cancer Risk and Individual Radiosensitivity

Patrono¹,

Sterpone²,

Testa³

et al. 2015

MEDJ

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Abstract:The aim of this paper is to analyse the role exerted by X-ray repair cross-complementing group 1 (XRCC1) genetic polymorphisms and haplotypes in increasing breast cancer risk and in modulating radiotherapy-induced adverse reactions. An Italian cohort of breast cancer patients and a matching group of healthy controls were genotyped for XRCC1-77T>C, Arg194Trp and Arg399Gln polymorphisms. Our data indicated that polymorphisms at codon 399 and at -77 position of the 5'-untraslated region both contribute to cancer risk. We also showed that the haplotype H3, containing the wild-type allele at codon 194 and the variant alleles at codon 399 and at -77 position is significantly associated with an increased risk of breast cancer. We found no statistical association between XRCC1 SNPs and individual radiosensitivity.

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“…Until now, no association between SNPs and late toxicity has been confirmed, either for BC or for prostate cancer [38] . Therefore, large, well-designed studies are needed to obtain more robust results.…”

Section: Resultsmentioning

confidence: 99%

“…The results of the meta-analysis by Xie et al [38] are summarised in Table 3. No significant association between the XRCC1 Arg399Gln SNP and IR-induced toxicity was observed in the overall analysis.…”

Section: Ape1mentioning

confidence: 99%

“…In particular, several studies on BC patients evaluating the association between the risk of acute and late skin reactions to RT and SNPs in DNA repair genes (especially XRCC1) were performed; however, these studies yielded conflicting results. Eleven studies on XRCC1 SNPs, mainly involving Caucasian patients, were collected in a recent meta-analysis [38] .…”

Section: Snps In Ber Genes and Radiosensitivitymentioning

confidence: 99%

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Polymorphisms in base excision repair genes: Breast cancer risk and individual radiosensitivity

Patrono

Sterpone

Testa

et al. 2014

WJCO

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Breast cancer (BC) is the most common cancer among women worldwide. The aetiology and carcinogenesis of BC are not clearly defined, although genetic, hormonal, lifestyle and environmental risk factors have been established. The most common treatment for BC includes breast-conserving surgery followed by a standard radiotherapy (RT) regimen. However, radiation hypersensitivity and the occurrence of RT-induced toxicity in normal tissue may affect patients' treatment. The role of DNA repair in cancer has been extensively investigated, and an impaired DNA damage response may increase the risk of BC and individual radiosensitivity. Single nucleotide polymorphisms (SNPs) in DNA repair genes may alter protein function and modulate DNA repair efficiency, influencing the development of various cancers, including BC. SNPs in DNA repair genes have also been studied as potential predictive factors for the risk of RT-induced side effects. Here, we review the literature on the association between SNPs in base excision repair (BER) genes and BC risk. We focused on X-ray repair cross complementing group 1 (XRCC1 ), which plays a key role in BER, and on 8-oxoguanine DNA glycosylase 1, apurinic/apyrimidinic endonuclease 1 and poly (ADP-ribose) polymerase-1, which encode three important BER enzymes that interact with XRCC1. Although no association between SNPs and radiation toxicity has been validated thus far, we also report published studies on XRCC1 SNPs and variants in other BER genes and RT-induced side effects in BC patients, emphasising that large well-designed studies are needed to determine the genetic components of individual radiosensitivity.© 2014 Baishideng Publishing Group Inc. All rights reserved.Key words: Breast cancer; Polymorphisms; Base excision repair; Susceptibility; Radiosensitivity Core tip: Single nucleotide polymorphisms (SNPs) in DNA repair genes may modulate DNA repair efficiency, influencing the development of various cancers, including breast cancer (BC). SNPs in DNA repair genes have also been studied as predictors for the risk of radiotherapy-induced side effects. We reviewed the literature on the association between SNPs in base excision repair (BER) genes and BC risk. We focused on X-ray repair cross complementing group 1, 8-oxoguanine DNA glycosylase 1, apurinic/apyrimidinic endonuclease 1 and poly (ADP-ribose) polymerase-1, which encode four important BER proteins. We also report published studies on SNPs in BER genes and individual radiosensitivity in BC patients.

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Predictive Value of Xrcc1 Gene Polymorphisms for Side Effects in Patients undergoing Whole Breast Radiotherapy: a Meta-analysis

Cited by 9 publications

References 38 publications

Topical Use of Recombinant Human Epidermal Growth Factor (EGF)-Based Cream to Prevent Radiation Dermatitis in Breast Cancer Patients: a Single-Blind Randomized Preliminary Study

Topical Use of Recombinant Human Epidermal Growth Factor (EGF)-Based Cream to Prevent Radiation Dermatitis in Breast Cancer Patients: a Single-Blind Randomized Preliminary Study

Polymorphisms in X-Ray Repair Cross-Complementing Group 1 Gene: Haplotypes, Breast Cancer Risk and Individual Radiosensitivity

Polymorphisms in base excision repair genes: Breast cancer risk and individual radiosensitivity

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