Predictive Values of Aspartate Aminotransferase and Gamma-Glutamyl Transferase for the Hepatic Accumulation of Copper in Cattle and Buffalo

Minervino, Antônio Humberto Hamad; Barrêto, Raimundo Alves; Queiróz, Genílson Fernandes de; Headley, Selwyn A.; Ortolani, Enrico Lippi

doi:10.1177/104063870802000613

Cited by 17 publications

(14 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…BHBA is a ketone that is found at high concentrations in the blood of dairy cows suffering from ketosis, which easily occurs during NEB [13]. γ-GTP is also known as a blood marker of liver abnormalities [27, 28]. We, therefore, conclude that there is likely a close relationship between the lower embryonic development competence of oocytes derived from cattle with liver disorders and the high concentrations of BHBA and γ-GTP.…”

Section: Discussionmentioning

confidence: 98%

The Developmental Potential of Oocytes is Impaired in Cattle with Liver Abnormalities

Sarentonglaga

Ogata

Taguchi

et al. 2013

Journal of Reproduction and Development

View full text Add to dashboard Cite

Here, we investigated the effect of liver abnormality on the developmental potential of bovine oocytes. Good quality oocytes from healthy cows and from animals with a liver abnormality were matured and fertilized in vitro and then cultured to the blastocyst stage. On day 7 after fertilization, embryo cleavage and development were assessed. The concentrations of glucose, nonesterified fatty acid (NEFA), γ-glutamyl transpeptidase (γ-GTP), β-hydroxybutyrate (BHBA) and glutathione were measured in follicular fluids (FF). The proportion of good quality oocytes and the frequency of development to the blastocyst stage were lower in the liver anomaly group than those of the control group (P<0.05). The concentrations of γ-GTP and BHBA in the FF of the liver anomaly group were higher than those of the control group (P<0.05). The concentration of glutathione in the FF of the liver anomaly group was lower than that of the control group (P<0.05). Moreover, there was a negative correlation between these concentrations and the proportions of oocytes that developed to the blastocyst stage (P<0.05). Supplementation of the culture medium with γ-GTP or BHBA did not affect the rate of oocyte maturation but did cause a concentration-dependent reduction in the frequency of fertilized oocytes that developed to the blastocyst stage. Our findings indicate that the quality of oocytes and their potential for development are lower in cattle with liver disorders than those in healthy cattle; one possible cause may be the high concentration of γ-GTP and/or BHBA in their FF.

show abstract

Section: Discussionmentioning

confidence: 98%

The Developmental Potential of Oocytes is Impaired in Cattle with Liver Abnormalities

Sarentonglaga

Ogata

Taguchi

et al. 2013

Journal of Reproduction and Development

View full text Add to dashboard Cite

show abstract

“…Heat stress during metabolically demanding conditions including lactation, pregnancy, or growth can put adverse effects on liver physiology, which is not the case with dry buffaloes as no changes in liver enzymes were observed during the summer season in the present study. Both AST and gamma-glutamyl transferase (GGT) have shown excellent predictive value for liver damage in cattle but in case of buffalo GGT is reported to be a more reliable indicator of liver damage ( 47 ). As we did not measure GGT in this study which is a limitation of the present study and should be considered in future studies.…”

Section: Discussionmentioning

confidence: 99%

Seasonal Dynamics of Physiological, Oxidative and Metabolic Responses in Non-lactating Nili-Ravi Buffaloes Under Hot and Humid Climate

Hassan

Guo

et al. 2020

Front. Vet. Sci.

View full text Add to dashboard Cite

“…Serum activity of hepatic enzymes, such as AST and GGT ( Figure 3) are used to diagnose hepatic impairment in domestic animals. The nature of hepatic pathology, whether necrotic or cholestatic, can be determined by the simultaneous analysis of the serum activity of the AST and GGT enzymes (Minervino et al, 2008). Some stimulation of exogenous origin, such as high concentrate feed and abrupt changes in diets, can cause damage to liver cells and the leakage of enzymes into the blood, increasing their levels (Braun et al, 1983;Moreira et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Wet citrus pulp in finishing diets for feedlot lambs:

Mello¹,

Moreira²,

Polizel³

et al. 2020

Braz. J. Vet. Res. Anim. Sci.

View full text Add to dashboard Cite

Pectin industry generates a citrus pulp residue compounded by peduncle, endocarp, juice vesicles, columella, seeds and tiny fractions of epicarp and mesocarp of citrus fruits, denominated Wet Citrus Pulp (WCP), which has not yet been tested as food for lamb’s nutrition. Thus, this study aimed to determine the effect of partial replacement of ground corn by WCP in high-concentrate diets on the performance and hepatic enzyme concentration of feedlot lambs. Forty-two male lambs (15 Santa Inês and 27 ½ Dorper × Santa Inês), with 24.7 ± 1.5 kg of BW and 60 ± 5 d of age was assigned to a randomized complete block design. Within blocks (n = 14), lambs were randomly assigned to 1 of 3 treatments: 0WCP (control) – diet containing 75.5% ground corn without WCP; 20WCP – diet containing 20% WCP in replacement of ground corn, and 40WCP – diet containing 40% WCP in replacement of ground corn. The experiment lasted 70 days, which was split in 3 experimental periods (14 days of diets’ adaptation and 2 sub-periods of 28 days each). Statistical analyses were performed using the MIXED procedure of the SAS. Orthogonal polynomials for diet response were determined by linear and quadratic effects. There was a quadratic effect for DM, CP, ash, ether extract and NFC intake The highest DM and CP intake was observed for lambs fed 20WCP, however, the control diet increased the ash, ether extract and NFC intake. The increased levels of WCP decreased the ADG and feed efficiency (FE) during the adaptation period, however, did not affect the ADG and FE on periods 1 and 2. Consequently, the increased levels of WCP inclusion decreased linearly the BW. There was no effect of WCP inclusion in diets on Gamma-Glutamyl Transferase (GGT) concentration. However, there was a linear increase for Aspartate Aminotransferase (AST) concentration during the adaptation period, but without difference in other periods. In conclusion, adding up to 40% of WCP in finishing diets for feedlot lambs decrease performance during adaptation period, compromising the final body weight, but without damages effects on liver enzymes.

show abstract

Predictive Values of Aspartate Aminotransferase and Gamma-Glutamyl Transferase for the Hepatic Accumulation of Copper in Cattle and Buffalo

Cited by 17 publications

References 9 publications

The Developmental Potential of Oocytes is Impaired in Cattle with Liver Abnormalities

The Developmental Potential of Oocytes is Impaired in Cattle with Liver Abnormalities

Seasonal Dynamics of Physiological, Oxidative and Metabolic Responses in Non-lactating Nili-Ravi Buffaloes Under Hot and Humid Climate

Wet citrus pulp in finishing diets for feedlot lambs:

Contact Info

Product

Resources

About