Predictor variables of the course of weight—a multicenter, prospective, controlled trial

Herpertz, Stephan; Kielmann, R.; Stang, Antonia; Siffert, Winfried; Joeckel, Karl-Heinz; Wolf, Anne; Husemann, B.; Senf, Wolfgang

doi:10.1016/s0022-3999(03)00157-0

Cited by 4 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In many cases, the primary objective of studies was not to assess BED through DSM‐IV research criteria. Rather, studies focused on identifying predictors of laparoscopic gastric banding complications , quantifying prevalence of mental disorders or assessing BED through eating behaviour scores . Consequently, original study groups had to be reconstructed to compare ‘exposed’ (mutation carriers) and ‘unexposed’ (non‐carriers) participants.…”

Section: Resultsmentioning

confidence: 99%

Gain‐of‐function variants in the melanocortin 4 receptor gene confer susceptibility to binge eating disorder in subjects with obesity: a systematic review and meta‐analysis

et al. 2018

View full text Add to dashboard Cite

Summary The association between coding variants in the melanocortin 4 receptor gene (MC4R) and binge eating disorder (BED) in patients with obesity is controversial. Two independent reviewers systematically searched MEDLINE, Embase, PsycINFO, BIOSIS Previews, Web of Science Core Collection and Google Scholar up to February 2018, using terms describing the MC4R gene and BED. Six of 103 identified references were included. Studies examined associations between at least one coding variant/mutation in MC4R and BED and screened for BED as per the Diagnostic and Statistical Manual of Mental Disorders. Risk of bias was assessed using a modified version of the Q‐Genie tool, and overall quality of evidence was assessed using Grading of Recommendations Assessment, Development and Evaluation guidance. Meta‐analysis was conducted via logistic regression models. A positive association between gain‐of‐function (GOF) variants in the MC4R and BED was observed (odds ratio [OR] = 3.05; 95% confidence interval [CI]: 1.82, 5.04; p = 1.7 × 10−5), while no association was detected between loss‐of‐function (LOF) mutations and BED (OR = 1.50; 95% CI: 0.73, 2.96; p = 0.25). Similar results were found after accounting for study quality (GOF variants: OR = 3.15; 95% CI: 1.76, 5.66; p = 1.1 × 10−4; LOF mutations: OR = 1.50; 95% CI: 0.73, 2.97; p = 0.25). Our systematic review and meta‐analysis provides evidence that GOF variants as opposed to LOF mutations in MC4R are associated with BED in subjects with obesity.

show abstract

Section: Resultsmentioning

confidence: 99%

Gain‐of‐function variants in the melanocortin 4 receptor gene confer susceptibility to binge eating disorder in subjects with obesity: a systematic review and meta‐analysis

et al. 2018

View full text Add to dashboard Cite

show abstract

“…A substantial percentage of bariatric surgery patients suffer from BED as a newly defined provisional eating disorder category included in the DSM (67) or BE symptoms in the sense of overeating episodes that are accompanied by both a subjective loss of control and significant emotional distress. Prevalence rates range from 7.3% (68) to 49% (31,69), respectively. Of the six studies explicitly evaluating BED as a possible predictor of weight loss and mental health, three studies used a prospective design (30,53,55), two a retrospective design (25,31), and one study compared different subsamples pre‐ and postsurgery (24).…”

Section: Resultsmentioning

confidence: 99%

Do Psychosocial Variables Predict Weight Loss or Mental Health after Obesity Surgery? A Systematic Review

et al. 2004

View full text Add to dashboard Cite

HERPERTZ, S., R. KIELMANN, A.M. WOLF, J. HEBEBRAND, AND W. SENF. Do psychosocial variables predict weight loss or mental health after obesity surgery? A systematic review. Obes Res. 2004;12:1554 -1569. Objective: The objective of this study was to present a systematic review of psychological and psychosocial predictors of weight loss and mental health after bariatric surgery. This systematic review included all controlled and noncontrolled trials of the last 2 decades with either a retrospective or prospective design and a follow-up period of at least 1 year. Research Methods and Procedures:The relevant literature was identified by a search of computerized databases. All articles published in English and German between 1980 and 2002 were reviewed. Results: Using the above inclusion/exclusion criteria, 29 articles were identified focusing on psychosocial predictors of weight loss and mental health after obesity surgery. Discussion: Personality traits have no predictive value for the postoperative course of weight or mental state. Apart from serious psychiatric disorders including personality disorders, psychiatric comorbidity seems to be of more predictive value for mental and physical well-being as two essential aspects of quality of life than for weight loss postsurgery. However, depressive and anxiety symptoms as correlates of psychological stress with regard to obesity seem to be positive predictors of weight loss postsurgery. The severity of the symptoms or the disorder is more relevant for the outcome of obesity surgery than the specificity of the symptoms. It is also not solely the consumption of distinct "forbidden" foods, such as sweets or soft drinks, but rather a general hypercaloric eating behavior, either as an expression of the patient's inadequate compliance or a dysregulation in energy balance, which is associated with a poor weight loss postsurgery.

show abstract

“…Immerhin 15 % der Patienten legten den Verdacht einer depressiven Störung nahe. Auf niedrigere Prävalenzen für depressive Störungen weisen die in einem strukturierten psychiatrischen Interview erhobenen Daten unserer eigenen z. T. laufenden kontrollierten prospektiven Studie[48]. In unserer Stichprobe von 140 chirurgischen Patienten mit dem Anliegen einer Adipositaschirurgie lag die Punktprävalenz für eine depressive Störung nach ICD-10 [49] bei 5,1 %, die Lifetime-Prävalenz bei 26 % im Vergleich zu 2,9 % bzw.…”

unclassified

“…2). zur Prävalenz der Binge-Eating-Störung bei Adipositaschirurgiepatienten schwanken je nach Literatur zwischen 8 %[48] und 47 %[52], wobei Studien, die strukturierte Interviews verwenden, die höchste Validität zukommt. Bariatrische Patienten mit Binge-Eating-Symptomatik wiegen mehr als Patienten ohne Binge-Eating-Symptomatik[53], sie sind im Allgemeinen depressiver und haben erheblich gröûere Selbstwertprobleme[2,54,55].…”

unclassified

Psychosoziale Aspekte der Adipositaschirurgie

Herpertz¹,

Kielmann²,

Wolf³

2002

Akt Ernähr Med

View full text Add to dashboard Cite

HinweisManuskript nach einem Vortrag bei der 17. Jahrestagung der Deutschen Adipositasgesellschaft in Bremen, 18. ± Zusammenfassung Konservative Gewichtsreduktionsmaûnahmen sind bei Menschen mit Adipositas permagna (Adipositas Grad III, BMI > 40 kg/m 2 ) in der Regel wenig Erfolg versprechend. Die Adipositaschirurgie hat sich bei sinkendem Operationsrisiko im Hinblick auf eine deutliche und dauerhafte Gewichtsreduktion bei zumindest zwei Drittel der Patienten bewährt. Dennoch stellt sich bei 30 % der operierten Patienten der postoperative Gewichtsverlauf unbefriedigend dar, wobei die Ursachen weniger im chirurgischen als vielmehr im psychiatrisch-psychosomatischen Fachgebiet zu finden sind und unter dem Begriff ¹Compliancestörungª unzureichend abgebildet werden. Auch in der Adipositaschirurgie gewinnt die Frage der Lebensqualität operierter Patienten zunehmend an Bedeutung. Der Begriff der Lebensqualität gründet sich nicht nur auf medizinische, sondern auch auf psychosoziale Aspekte, die wiederum mit psychiatrischen/psychosomatischen Symptomen oder Störungen untrennbar verbunden sind. Nicht zuletzt durch die Grundsatzstellungnahme des Medizinischen Dienstes der Spitzenverbände der Krankenkassen wird die Adipositaschirurgie nicht nur unter dem Aspekt der Gewichtsabnahme und des Morbiditäts-und Mortalitätsrisikos, sondern auch im Hinblick auf Fragen der Lebensqualität kontrovers diskutiert. Die vorliegende Arbeit unternimmt den Versuch, psychosomatische Aspekte der Adipositaschirurgie kritisch zu beleuchten, um letztendlich die Notwendigkeit sowohl einer spezialisierten chirurgischen als auch psychiatrischen/psychosomatischen Diagnostik und Behandlung herauszustellen. AbstractConservative weight reduction measures in people with morbid obesity (BMI > 40 kg/m 2 ) are as a rule not very promising. Obesity surgery with an increasingly lower operation risk has proven to be successful with regard to weight reduction in at least two thirds of those patients operated on; in 30 % of the operated patients, however, the postoperative course of weight is unsatisfactory. The reasons for this may not necessarily be found in the surgical but rather in the psychiatric/psychosomatic field and are described inadequately by the term ¹compliance disorderª. In obesity surgery, the question regarding the quality of life in operated patients has increasingly gained importance. The term quality of life is not only based on medical but also on psychosocial aspects; these in turn are inseparately connected to psychiatric/ psychosomatic symptoms or disorders. It is lastly not only due to the basic principles set up by the medical services of the insurance companies that obesity surgery is discussed quite controversially with regard to weight reduction, morbidity and mortality risks as well as with regard to quality of life. The aim of the present paper is to illuminate the psychosomatic aspects of obesity surgery in order to expose and emphasize the necessity for both a specialized surgery as well as psychiatric/psychosomatic diagnostics an...

show abstract

Predictor variables of the course of weight—a multicenter, prospective, controlled trial

Cited by 4 publications

References 0 publications

Gain‐of‐function variants in the melanocortin 4 receptor gene confer susceptibility to binge eating disorder in subjects with obesity: a systematic review and meta‐analysis

Gain‐of‐function variants in the melanocortin 4 receptor gene confer susceptibility to binge eating disorder in subjects with obesity: a systematic review and meta‐analysis

Do Psychosocial Variables Predict Weight Loss or Mental Health after Obesity Surgery? A Systematic Review

Psychosoziale Aspekte der Adipositaschirurgie

Contact Info

Product

Resources

About