Predictors and consequences of adherence to the treatment of pediatric patients with attention-deficit/hyperactivity disorder in Central Europe and East Asia

Hong, Jihyung; Novick, Diego; Treuer, Tamás; Montgomery, William; Haynes, Virginia S.; Wu, Shenghu; Haro, Josep María

doi:10.2147/ppa.s50628

Cited by 27 publications

(34 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The family history of ADHD needs to be taken into account in children and adolescents treated for ADHD, because it may have negative effects on adherence to ADHD medication in children (Gau et al, 2008;Hong et al, 2013).…”

Section: Factors With Possible Influence On Adherence Behaviour In Asmentioning

confidence: 99%

“…In asthma, concomitant depressive symptoms were accompanied by less adherence to the prescribed medication (Krauskopf et al, 2013;Smith et al, 2006). In ADHD, children with a high Body Mass Index (BMI) were prone to show low adherence to ADHD medication treatment (Hong et al, 2013). Severity may impact on adherence differently depending on which disease is involved.…”

Section: Factors With Possible Influence On Adherence Behaviour In Asmentioning

confidence: 99%

“…Non-adherence behaviour related to ADHD medication is linked to less symptom improvement (Gau et al, 2008;Hong et al, 2013), encompassing less active interaction with parents and more severe behaviour problems at home in children (Gau et al, 2006), as well as lower academic grades in students (Marcus & Durkin, 2011).…”

Section: Effects Of Low Adherence In Asthma and Adhdmentioning

confidence: 99%

“…The negative effects of suboptimal adherence to asthma (Darba et al, 2016;Murphy et al, 2012;Stern et al, 2006;Williams et al, 2011;Williams et al, 2004) and ADHD medication (Gau et al, 2008;Gau et al, 2006;Hong et al, 2013;Marcus & Durkin, 2011) are detrimental to the individual and need to be prevented. This should be possible to some degree, as the beneficial effects of prevention actions directed against nonadherence are recognized.…”

Section: Adherence To Medicationmentioning

confidence: 99%

“…Low adherence to long-term therapy may influence treatment effects (Gau et al, 2008;Hong et al, 2013;Murphy et al, 2012), which in turn affect people's health (Sabaté, 2003;Stern et al, 2006;Williams et al, 2011). This is a concern, because some studies have found that about 50% of those on prescribed medication are reported to not adhere to the pharmacological therapy recommended by health care providers (Sabaté, 2003).…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Treatment adherence in Asthma and Attention Deficit Hyperactivity Disorder (ADHD), Personality traits, Beliefs about medication and Illness perception

Emilsson¹

2017

Linköping University Medical Dissertations

View full text Add to dashboard Cite

Adherence to medication in asthma and attention deficit hyperactivity disorder (ADHD) is important because medication may prevent serious consequences, possibly with lifelong effects. Several factors have been identified that influence adherence to medication in these disorders, but the importance of personality traits, beliefs about medication and illness perception has been insufficiently explored. The overall aim of this thesis was to study adherence to medication in asthma and ADHD, and in particular factors associated with adherence.The participants (n=268) in Study I were recruited epidemiologically and consisted of young adults with asthma, aged 22 years (±1 year). Impulsivity and, in men Antagonism and Alexithymia were associated with low adherence among respondents with regular asthma medication (n=109). The participants (n=35) in Study II were recruited from primary care clinics and consisted of adults (mean age 53 years). In men, Neuroticism was associated with low adherence, but Conscientiousness with high adherence. Beliefs about the necessity of medication were positively associated with adherence behaviour in women. In the total sample, a positive necessity-concern differential of beliefs predicted higher adherence. The participants in Study III, IV (n=101) and V (n=99) were recruited from Child and Adolescent Psychiatric clinics and consisted of adolescents with ADHD on long-term ADHD medication. Study IV assessed the reliability and validity of Swedish translations of the Beliefs about Medicines Questionnaire-specific (BMQ-Specific) and Brief Illness Perception Questionnaire (B-IPQ) for use in adolescents with ADHD. Exploratory Principal Component Analysis (PCA) loadings of the BMQ-Specific items confirmed the original components, the specific-necessity and specific-concerns. The exploratory PCA for B-IPQ revealed two components; the first one, B-IPQ Consequences, captured questions regarding perceptions of the implication of having ADHD (items 1, 2, 5, 6 and 8) and the second one, B-IPQ-Control, the perceptions of the ability to manage the ADHD disorder (items 3, 4 and 7). Adherence correlated positively with BMQnecessity-concern differential but negatively with beliefs about medication regarding concerns and side effects as well as Antagonism. Adolescents with more beliefs in the necessity, but with less concerns and side effects were less intentionally non-adherent. Adolescents with more perceptions that ADHD affected life showed less unintentional non-adherence. Negative Affectivity was associated with beliefs in the necessity of medication, but also with concern about medication and side effects. Negative Affectivity was positively associated with perceived consequences in life caused by ADHD and less control over ADHD. Hedonic Capacity was associated with less concerns about medication. In conclusion: In asthma and ADHD, adherence was associated with personality and beliefs about medications treatment. The personality traits showed numerous associations with perception about ADHD a...

show abstract

Section: Factors With Possible Influence On Adherence Behaviour In Asmentioning

confidence: 99%

Section: Factors With Possible Influence On Adherence Behaviour In Asmentioning

confidence: 99%

Section: Effects Of Low Adherence In Asthma and Adhdmentioning

confidence: 99%

Section: Adherence To Medicationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Treatment adherence in Asthma and Attention Deficit Hyperactivity Disorder (ADHD), Personality traits, Beliefs about medication and Illness perception

Emilsson¹

2017

Linköping University Medical Dissertations

View full text Add to dashboard Cite

show abstract

Methylphenidate for attention deficit hyperactivity disorder (ADHD) in children and adolescents - assessment of adverse events in non-randomised studies

Storebø

Pedersen

Ramstad

et al. 2018

Cochrane Database of Systematic Reviews

244

161

View full text Add to dashboard Cite

Our findings suggest that methylphenidate may be associated with a number of serious adverse events as well as a large number of non-serious adverse events in children and adolescents, which often lead to withdrawal of methylphenidate. Our certainty in the evidence is very low, and accordingly, it is not possible to accurately estimate the actual risk of adverse events. It might be higher than reported here.Given the possible association between methylphenidate and the adverse events identified, it may be important to identify people who are most susceptible to adverse events. To do this we must undertake large-scale, high-quality RCTs, along with studies aimed at identifying responders and non-responders.

show abstract

Beliefs regarding medication and side effects influence treatment adherence in adolescents with attention deficit hyperactivity disorder

Emilsson

Gustafsson

Öhnström

et al. 2016

Eur Child Adolesc Psychiatry

View full text Add to dashboard Cite

Adherence to attention deficit hyperactivity disorder (ADHD) treatment is important because, when untreated, it may have serious consequences with lifelong effects. In the case of adolescents on long-term medicine prescription, more knowledge is needed regarding adherence and factors influencing adherence, which was the purpose of this study. Adolescents (n = 101) on ADHD medication ≥6 months were administrated questionnaires at a monitoring appointment: Medication Adherence Report Scale (MARS), beliefs about medicines (BMQ) and the Brief Illness Perception Questionnaire (B-IPQ). Adherence was high, the mean value was 88% of the maximum MARS score, and correlated positively with the “BMQ-necessity-concerns differential” but negatively with “BMQ-concerns” and “BMQ-side effects”. Adolescents with more belief in the necessity of the medication, less concerns and less experience of side effects tended to be more adherent to medication prescription (“intentional non-adherence”), while “unintentional non-adherence” (forgetfulness) was associated with how much they perceived that their ADHD affected their lives. In a multiple regression model, the variance of MARS total (R 2 = 0.21) and “intentional non-adherence” (R 2 = 0.24) was explained by the “BMQ-necessity–concern differential” and “BMQ-experienced side effects”. The variance of “unintentional non-adherence” (R 2 = 0.12) was explained by the “BMQ-necessity–concern differential” and “B-IPQ-consequences of ADHD”. In conclusion, adolescents on long-term medication reported good adherence, mainly influenced by more beliefs in the necessity versus concerns of the medications, less experienced side effects and more perceived consequences of ADHD. BMQ could be useful to identify risks of low adherence, which should be counteracted by partially gender-specific interventions.Electronic supplementary materialThe online version of this article (doi:10.1007/s00787-016-0919-1) contains supplementary material, which is available to authorized users.

show abstract

Predictors and consequences of adherence to the treatment of pediatric patients with attention-deficit/hyperactivity disorder in Central Europe and East Asia

Cited by 27 publications

References 35 publications

Treatment adherence in Asthma and Attention Deficit Hyperactivity Disorder (ADHD), Personality traits, Beliefs about medication and Illness perception

Treatment adherence in Asthma and Attention Deficit Hyperactivity Disorder (ADHD), Personality traits, Beliefs about medication and Illness perception

Methylphenidate for attention deficit hyperactivity disorder (ADHD) in children and adolescents - assessment of adverse events in non-randomised studies

Beliefs regarding medication and side effects influence treatment adherence in adolescents with attention deficit hyperactivity disorder

Contact Info

Product

Resources

About