Predictors and management of chest wall toxicity after lung stereotactic body radiotherapy

Shaikh, Talha; Turaka, Aruna

doi:10.1016/j.ctrv.2014.09.003

Cited by 17 publications

(3 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These variables need to be accurately reported and considered in statistical analyses of results, as they may cause inconsistencies in findings between experimental groups within a research project and between separate studies. Radiation exposure at a young age has long been known to lead to more severe long-term normal tissue radiation injury compared to radiation exposure in adults [156]. Mulrooney et al reported health outcomes in a cohort of just over 14,000 survivors of childhood and adolescent cancer and found that this population was at substantial risk for cardiovascular disease, with a two-to six-fold increased relative risk for coronary events in patients who had received >15 Gy to the heart compared to non-irradiated survivors [157].…”

Section: Preclinical Models To Study Cardiac Radiation Toxicities: Anmentioning

confidence: 99%

Advances in Preclinical Research Models of Radiation-Induced Cardiac Toxicity

Schlaak

SenthilKumar

Boerma

et al. 2020

Cancers

View full text Add to dashboard Cite

Radiation therapy (RT) is an important component of cancer therapy, with >50% of cancer patients receiving RT. As the number of cancer survivors increases, the short-and long-term side effects of cancer therapy are of growing concern. Side effects of RT for thoracic tumors, notably cardiac and pulmonary toxicities, can cause morbidity and mortality in long-term cancer survivors. An understanding of the biological pathways and mechanisms involved in normal tissue toxicity from RT will improve future cancer treatments by reducing the risk of long-term side effects. Many of these mechanistic studies are performed in animal models of radiation exposure. In this area of research, the use of small animal image-guided RT with treatment planning systems that allow more accurate dose determination has the potential to revolutionize knowledge of clinically relevant tumor and normal tissue radiobiology. However, there are still a number of challenges to overcome to optimize such radiation delivery, including dose verification and calibration, determination of doses received by adjacent normal tissues that can affect outcomes, and motion management and identifying variation in doses due to animal heterogeneity. In addition, recent studies have begun to determine how animal strain and sex affect normal tissue radiation injuries. This review article discusses the known and potential benefits and caveats of newer technologies and methods used for small animal radiation delivery, as well as how the choice of animal models, including variables such as species, strain, and age, can alter the severity of cardiac radiation toxicities and impact their clinical relevance.

show abstract

Section: Preclinical Models To Study Cardiac Radiation Toxicities: Anmentioning

confidence: 99%

Advances in Preclinical Research Models of Radiation-Induced Cardiac Toxicity

Schlaak

SenthilKumar

Boerma

et al. 2020

Cancers

View full text Add to dashboard Cite

show abstract

“…The 'mediastinum' was expanded 5 mm to create a planning risk volume (PRV mediastinal envelope) to account for setup inaccuracy or movement. The ribs were contoured within 5 cm of the PTV (excluding the intercostal space; [15]). The chest wall constituted of a 1.5-cm expansion from the lungs.…”

Section: Target and Oar Definitionsmentioning

confidence: 99%

Photons, protons or carbon ions for stage I non-small cell lung cancer – Results of the multicentric ROCOCO in silico study

Wink

Roelofs

Simone

et al. 2018

Radiotherapy and Oncology

View full text Add to dashboard Cite

“…Anti-inflammatory medications are the primary analgesic followed by gabapentin or narcotics if required. 36 Pain requiring intervention has been reported in up to 24% of patients and rib fracture in up to 42% of those with peripheral tumors treated by SBRT. 37,38 However, around two-thirds of rib fractures will be asymptomatic.…”

Section: Toxicity Chest Wallmentioning

confidence: 99%

Treatment of Peripheral Non-Small Cell Lung Carcinoma with Stereotactic Body Radiation Therapy

Roach

Videtic

Bradley

2015

Journal of Thoracic Oncology

View full text Add to dashboard Cite

Stereotactic body radiation therapy (SBRT) is an effective and well-tolerated noninvasive treatment for medically inoperable patients with peripheral non-small cell lung carcinoma. The term "peripheral" refers to lesions that lie 2 cm or more from the mediastinum and proximal bronchial tree and was instituted based on results from a specific dose and fractionation schedule. Improvements in immobilization, respiratory motion management, and image guidance have allowed for SBRT's highly conformal and accurate delivery of large radiation doses per fraction. Results from prospective and retrospective studies suggest that lung SBRT has superior outcomes when compared with conventionally fractionated treatments and is comparable with surgical resection. Investigations into the optimal SBRT dosing regimen for peripheral lesions are ongoing, with recent trials suggesting comparable efficacy between single and multiple fraction schedules. Chest wall toxicity after peripheral treatment is common, but it usually resolves with conservative management. Pneumonitis is less often observed after treatment of peripheral lesions, and changes in pulmonary function tests are minimal. Studies in the frail and elderly suggest that neither baseline pulmonary function tests nor age should preclude treatment. Recent technical developments have reduced delivery time and resulted in more conformal treatments. This review is on behalf of the IASLC Advanced Radiation Technology Committee.

show abstract

Predictors and management of chest wall toxicity after lung stereotactic body radiotherapy

Cited by 17 publications

References 53 publications

Advances in Preclinical Research Models of Radiation-Induced Cardiac Toxicity

Advances in Preclinical Research Models of Radiation-Induced Cardiac Toxicity

Photons, protons or carbon ions for stage I non-small cell lung cancer – Results of the multicentric ROCOCO in silico study

Treatment of Peripheral Non-Small Cell Lung Carcinoma with Stereotactic Body Radiation Therapy

Contact Info

Product

Resources

About