2013
DOI: 10.1093/eurjhf/hft004
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Predictors and prognostic implications of incident heart failure following the first diagnosis of atrial fibrillation in patients with structurally normal hearts: the Belgrade Atrial Fibrillation Study

Abstract: AimAtrial fibrillation (AF) commonly co-exists with heart failure (HF). The risk factors for and prognostic implications of incident HF development in patients with first-diagnosed AF and structurally normal hearts are poorly defined. In a cohort of patients with first-diagnosed AF and structurally normal hearts on baseline echocardiography, we investigated baseline risk factors for the development of incident HF and tested the hypothesis that incident HF was an independent predictor of adverse outcomes during… Show more

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Cited by 60 publications
(50 citation statements)
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“…Previous studies of incident HF in those with AF (1214) have focused primarily on risk prediction and, as such, have incorporated both modifiable and non-modifiable risk factors assessed at AF baseline. The clinical impact of these studies is limited, however, by the absence of evidence for HF preventive therapies in AF.…”
Section: Discussionmentioning
confidence: 99%
“…Previous studies of incident HF in those with AF (1214) have focused primarily on risk prediction and, as such, have incorporated both modifiable and non-modifiable risk factors assessed at AF baseline. The clinical impact of these studies is limited, however, by the absence of evidence for HF preventive therapies in AF.…”
Section: Discussionmentioning
confidence: 99%
“…To date, three models have been developed with C statistics ranging from 0.7 to 0.84, but none has been externally validated. [127][128][129] Future models might also benefit from inclusion of non-invasive measures of cardiac function and assessments of novel biomarkers.…”
Section: Strengths and Limitationsmentioning
confidence: 99%
“…140 Smoking was not a risk factor for incident heart failure in individuals with AF. 141,142 Neither the CHADS 2 nor the CHA 2 DS 2 –VASc scores include smoking as a risk factor for stroke. However, smoking is a risk factor for stroke in AF, even accounting for coexisting risk factors, 143,144 but this relationship was not evident in one study.…”
Section: Introductionmentioning
confidence: 99%