Predictors for cognitive impairment one year after surgery for aneurysmal subarachnoid hemorrhage

Ørbo, Marte; Waterloo, Knut; Egge, Arild; Isaksen, Jørgen Gjernes; Ingebrigtsen, Tor; Romner, Bertil

doi:10.1007/s00415-008-0047-z

Cited by 52 publications

(63 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…No specific physiopathological mechanism to explain the cognitive dysfunction has been identified, but severity of initial presentation and volume of subarachnoid blood have often been correlated with cognitive outcomes. 7,10,26 The influence of other factors such as hydrocephalus, aneurysm location, treatment method, vasospasm, and ischemic complications on neurocognitive sequelae are less clear. 10,12,16,28 These pathological processes are acute or subacute issues and would not be expected to lead to permanent deficits in the absence of ischemic damage to the neural tissue.…”

Section: Discussionmentioning

confidence: 99%

Increased Frontal Lobe Activation After Aneurysmal Subarachnoid Hemorrhage

Costa

Dunkley

Bethune

et al. 2016

Stroke

View full text Add to dashboard Cite

Background and Purpose— Neurocognitive deficits are common among survivors of aneurysmal subarachnoid hemorrhage, even among those with good outcomes and no structural lesions. This study aims to probe the neurophysiological underpinnings of cognitive dysfunction among patients with ruptured intracranial aneurysms using magnetoencephalography (MEG). Methods— Thirteen patients who had undergone uncomplicated coiling for aneurysmal subarachnoid hemorrhage and 13 matched controls were enrolled. Neuropsychological tests were done before magnetoencephalography scans. Magnetoencephalography data were acquired in a 151-channel, whole-head magnetoencephalography system for resting state and 2 cognitive tasks (go-no-go and set-shifting). Mean time from treatment to test was 18.8 months. Results— Cognitive tasks of inhibition (go-no-go) indicated greater activation in the right anterior cingulate and inferior frontal gyrus, and cognitive set-shifting tasks (mental flexibility) indicated greater activity in the bilateral anterior cingulate cortex and right medial frontal gyrus among aneurysmal subarachnoid hemorrhage patients, with significantly different timing of activation between groups. Resting-state, beta-band connectivity of the anterior cingulate correlated negatively with Montreal Cognitive Assessment scores (left: r =−0.56; P <0.01 and right: r =−0.55; P <0.01): higher connectivity of this region was linked to poorer cognitive test performance. Conclusions— We have shown increased activation in areas of the anterior cingulate gyrus and frontobasal regions during the execution of more demanding tasks in good grade. The degree of activation in the anterior cingulate gyrus has a negative correlation with cognitive (Montreal Cognitive Assessment) scores. These subtle differences may be related to the common neurocognitive and behavioral complaints seen in this patient population.

show abstract

Section: Discussionmentioning

confidence: 99%

Increased Frontal Lobe Activation After Aneurysmal Subarachnoid Hemorrhage

Costa

Dunkley

Bethune

et al. 2016

Stroke

View full text Add to dashboard Cite

show abstract

“…Consequently, the prevalence of executive dysfunction in aSAH survivors is very wide with estimates ranging from 3% to 76%. 10,[12][13][14][15][16][17][18][19]37 Interestingly, self-reported deficits in executive function do not appear to correlate with results from objective cognitive tests; Ravnik and colleagues 38 found that patients with aSAH reported attentional deficits most frequently, yet patients performed better on tests of attention than on tests of other cognitive domains. Discordance between self-reported cognitive deficits and results from objective cognitive tests has also been reported in other domains, like memory.…”

Section: Executive Functionmentioning

confidence: 99%

“…Findings from most other studies, however, suggest no relationship between ruptured aneurysm location and the profile of cognitive impairment. 13,20,22,32,41,42 Interestingly, Manning and colleagues 43 found that patients with aSAH who had ruptured anterior communicating artery aneurysms (proximal to the frontal lobes) performed significantly better than patients with nonanterior aneurysms on the Tower of London task, 44 a test of executive function. The relationship between aneurysm location and the profile of cognitive impairment thus remains unclear.…”

Section: Executive Functionmentioning

confidence: 99%

“…Among studies conducted in the past 10 years, deficits in cognitive flexibility, as measured by the Wisconsin Card Sorting Task, were found in 8% to 44% of patients with aSAH, 12,13,[15][16][17]19 whereas deficits in inhibition, as measured by the Stroop task, were found in 17% to 56% of patients with aSAH. 13,15,16 A study by Manning and colleagues 43 highlights the need to address different aspects of executive function. Manning and colleagues 43 evaluated executive function in 35 aSAH survivors who had made a "good recovery" according to the Glasgow Outcome Scale (GOS).…”

Section: Executive Functionmentioning

confidence: 99%

See 1 more Smart Citation

Cognitive and Functional Outcome After Aneurysmal Subarachnoid Hemorrhage

Al-Khindi

Macdonald

Schweizer

2010

Stroke

664

478

View full text Add to dashboard Cite

Background and Purpose-Aneurysmal subarachnoid hemorrhage (aSAH) is a medical emergency characterized by the accumulation of blood in the subarachnoid space surrounding the brain. The acute treatment of aSAH is well documented but less is known about the long-term effects of aSAH on cognition and day-to-day functioning. Methods-We reviewed all studies in the past 10 years that have focused on the effects of aSAH on cognition and day-to-day functioning. Results-Sixty-one empirical studies examining cognitive and functional outcome in patients with aSAH met inclusion criteria. Survivors of aSAH commonly experience deficits in memory, executive function, and language. These cognitive impairments interact to affect patients' day-to-day functioning, including activities of daily living, instrumental activities of daily living, return to work, and quality of life. Deficits in cognition and day-to-day functioning are further compounded by depression, anxiety, fatigue, and sleep disturbances. Conclusions-Much remains to be learned about the brain changes underlying cognitive and functional deficits, including the role of diffuse brain damage and secondary complications like vasospasm and elevated intracranial pressure. A consideration of these issues is necessary to obtain a better understanding of how aSAH affects cognition and day-to-day functioning in the long-term. (Stroke. 2010;41:e519-e536.)

show abstract

“…Some authors claim that there is no correlation between these two aspects (8,15,16), whereas others state the opposite (17) .…”

Section: Introductionmentioning

confidence: 99%

Caracterização das afasias na hemorragia subaracnóidea aneurismática

Maranhão

Souza

Costa

et al. 2018

CoDAS

View full text Add to dashboard Cite

RESUMO Objetivo Caracterizar o perfil dos quadros afásicos determinados pela hemorragia subaracnóidea aneurismática (HSA) da artéria cerebral média esquerda. Método Estudo analítico, retrospectivo, transversal, tendo como banco de dados as avaliações cognitivas de 193 pacientes do Hospital da Restauração com HSA aneurismática no período de março de 2007 a novembro de 2009. Destes, foram selecionados 26 pacientes com HSA em território da ACM-E, confirmada por angiografia digital. Os quadros afásicos foram classificados através do desempenho da linguagem dos pacientes através do Protocolo Montreal Toulose - Versão Alpha e a tarefa de fluência verbal da bateria CERAD. A pesquisa foi realizada no período de junho a agosto de 2015. Resultados Foi identificado comprometimento da linguagem e fluência verbal nos pacientes com HSA em território de ACM–E quando comparados com a população controle (50 indivíduos). Dos 26 pacientes com HSA, 11 apresentaram quadros afásicos ainda no período pré-operatório. Conclusão Os resultados da pesquisa corroboram com a literatura, mostrando que o quadro da HSA promove comprometimentos cognitivos ainda na fase pré-operatória para oclusão de aneurisma. Tendo em vista os aspectos observados, os quadros afásicos predominantes caracterizam afasia de compreensão por sequelas nas áreas cerebrais posteriores.

show abstract

Predictors for cognitive impairment one year after surgery for aneurysmal subarachnoid hemorrhage

Abstract: The severity of cognitive impairment one year post SAH is predicted by the volume of blood in the subarachnoid space as measured by the Fisher score.

Cited by 52 publications

References 44 publications

Increased Frontal Lobe Activation After Aneurysmal Subarachnoid Hemorrhage

Increased Frontal Lobe Activation After Aneurysmal Subarachnoid Hemorrhage

Cognitive and Functional Outcome After Aneurysmal Subarachnoid Hemorrhage

Caracterização das afasias na hemorragia subaracnóidea aneurismática

Contact Info

Product

Resources

About