Predictors for erectile dysfunction among diabetics

Zheng, Hui; Wang, Fan; Li, Guangwei; Tam, Theresa

doi:10.1016/j.diabres.2005.07.011

Cited by 46 publications

(43 citation statements)

References 21 publications

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“…This study also showed that glycemic control, as assessed by HbA1c level, was a risk factor for ED in diabetic men. In previous studies, glycemic control was reported to be positively and significantly associated with ED, [9][10][11]24 whereas in other studies it was of marginal [25][26][27] or null [12][13][14] significance. The reasons for these discrepancies among different observational studies are not readily apparent; apart from evident differences in sample size, the role of glycemic control as a risk factor for ED in diabetic men has been studied by adopting multivariate analysis strategy for most; the number and the diversity of covariates included in the model, as well as the way to select covariates for model building might have produced biased results.…”

Section: Discussionmentioning

confidence: 91%

“…12 A recent assessment of the association between physical activity and ED comes from a meta-analysis of population-based studies showing the existence of a simple doseresponse relationship, with higher physical activity conferring lower risks. The adjusted reduction of the risk of having ED was 58% for high activity and 37% for moderate activity, as compared with men with low physical activity.…”

Section: Discussionmentioning

confidence: 99%

“…Some observational studies have shown that a poor glycemic control, as reflected by higher values of glycated hemoglobin A1c (HbA1c), was associated with higher risk of ED, [9][10][11] whereas other studies did not find an association. [12][13][14] The reasons for these divergent results are not evident; however, diabetic men may be afflicted by a multitude of comorbidities, including hypertension, overweight or obesity, the metabolic syndrome, atherogenic dyslipidemia, cigarette smoking, autonomic neuropathy, and so on, all of which are by themselves risk factors for ED. 11,15,16 Moreover, the different approaches used in the different studies, such as, although not limited to inappropriate sample size, and statistical analyses, may have contributed to these divergent results.…”

Section: Introductionmentioning

confidence: 99%

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Determinants of erectile dysfunction in type 2 diabetes

et al. 2010

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This study was designed to evaluate the prevalence and correlates of ED in a population of diabetic men. Consecutive patients with type 2 diabetes were recruited among outpatients regularly attending Diabetes Clinics. Inclusion criteria for the initial selection of patients were a diagnosis of type 2 diabetes for at least 6 months but less than 10 years, age 35-70 years, body mass index (BMI) of 24 or higher, HbA1c of 6.5% or higher: a total of 555 (90.8%) of the 611 men were analyzed in this study. ED was assessed by the IIEF-5 instrument. Approximately, 6 in 10 men in our sample of diabetic men had varying degrees of erectile dysfunction: mild 9%, mild to moderate 11.2%, moderate 16.9% and severe 22.9%. The prevalence of severe ED increased with age. Higher hemoglobin A1c (HbA1c) levels were associated with ED; similarly, the presence of metabolic syndrome, hypertension, atherogenic dyslipidemia (low levels of HDL-cholesterol and high levels of triglycerides) and depression was associated with ED. Physical activity was protective of ED; men with higher levels of physical activity were 10% less likely to have ED as compared with those with the lowest level. In conclusion, among subjects with type 2 diabetes glycemic control and other metabolic covariates were associated with ED risk, whereas higher level of physical activity was protective. These results encourage the implementation of current medical guidelines that place intensive lifestyle changes as the first step of the management of type 2 diabetes.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Determinants of erectile dysfunction in type 2 diabetes

et al. 2010

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“…Diabetes mellitus DM is a major (if not the principal) risk factor for both ED and CVD [122][123][124][125][126] and is associated with both neuropathy and endothelial dysfunction, both cardinal risk factors for ED and diabetic angiopathy. The metabolic syndrome, the criteria for which include glucose intolerance, obesity, hypertension and dyslipidaemia, is now associated with ED.…”

Section: Ros Andmentioning

confidence: 99%

Reactive oxygen species and erectile dysfunction: possible role of NADPH oxidase

et al. 2006

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Erectile dysfunction (ED) is a widespread condition, the incidence of which is increasing globally. ED is also indicative of underlying vasculopathy and represents a predictor of more serious cardiovascular disorders. Understanding the aetiology of ED may therefore provide invaluable pointers to the pathobiology of other cardiovascular diseases (CVDs) and syndromes. It follows, too, that therapeutic interventions that are successful in treating ED may, ipso facto, be effective in treating the early stages of conditions that include atherosclerosis, angina, plaque rupture and diabetic angiopathy. One common pathological denominator in both CVD and ED is oxidative stress, that is, the overproduction of reactive oxygen species (ROS), in particular, superoxide (O 2 KÀ ) and hydrogen peroxide (H 2 O 2 ). In this review, therefore, we consider the aetiology and pathobiology of O 2 KÀ in promoting ED and focus on NADPH oxidase as an inducible source of O 2 KÀ and H 2 O 2 . Therapeutic strategies aimed at reducing oxidative stress to improve erectile function are also discussed.

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“…Sexual dysfunction was reported by 22% of diabetic men. Sexual dysfunction is related to age, BMI, duration of diabetes, and diabetic complications (Zheng, Fan, Li, & Tam, 2006). There was no correlation with glycosylated hemoglobin.…”

Section: Diabetes Mellitusmentioning

confidence: 99%

Epidemiology of Male Sexual Dysfunction

Hatzimouratidis

2007

Am J Mens Health

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Predictors for erectile dysfunction among diabetics

Cited by 46 publications

References 21 publications

Determinants of erectile dysfunction in type 2 diabetes

Determinants of erectile dysfunction in type 2 diabetes

Reactive oxygen species and erectile dysfunction: possible role of NADPH oxidase

Epidemiology of Male Sexual Dysfunction

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