Predictors of Adherence to Antiretroviral Therapy among HIV/AIDS Patients in the Upper West Region of Ghana

Obirikorang, Christian; Selleh, Peter Kuugemah; Abledu, Jubilant Kwame; Fofie, Chris

doi:10.1155/2013/873939

Cited by 57 publications

(86 citation statements)

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“…The relationship between perceived benefit and barrier and ARV therapy adherence The result of the study showed that there was a relationship between perceived benefit and barrier and the compliance to ARV therapy which was statistically significant with the score of (p= 0.016), high perceived benefit and barrier would increase the compliance to conduct ARV therapy. These results supported the research of Obirikorang et al (2013) which stated that other diseases and drug side effects negatively affected the adherence of ARV therapy while the perceptions of health, family support and regularity have a positive effect on ARV therapy.…”

Section: The Relationship Between Know-supporting

confidence: 88%

Association between Knowledge, Perceived Seriousness, Perceived Benefit and Barrier, and Family Support on Adherence to Anti-Retrovirus Therapy in Patients with HIV/AIDS

Sunaryo¹,

Demartoto

Adriyani³

2016

J HEALTH PROMOT BEHAV

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Background: The cumulative of HIV/AIDS cases in Surakarta are 1.212 cases, and 376 of them died in the span of Oktober 2005 until Januari 2014 . HIV infections have not found a cure, so it is possible someone with AIDS often experience psychological problems, especially anxiety, depression, which can suppress the immune system, making people more vulnerable against illness and pain. AIDS can not be cured, but the life expectancy of people living with HIV/ AIDS (PLWHA) can be extended with antiretroviral treatment (ART). This treatment can boost immunity so that the quality of life of PLHIV increased. Subjects and Method: The study was observational analytic research with cross sectional design. The location of research in PHC Manahan Surakarta total of 36 patients with HIV / AIDS who do ARV therapy. The data analysis using logistic regression. Results: There is a positive correlation was not statistically significant from the knowledge of the drugs with antiretroviral therapy adherence (OR=4.03; 95% CI= 0.22 to 73.32; p=0.347). There is a positive correlation was statistically significant on the perception of the seriousness of the disease with antiretroviral therapy adherence (OR=26.70; 95% CI= 1.30 to 550.51; p=0.033). There is a positive relationship and statistically significant on the perception of the benefits and barriers to compliance with antiretroviral therapy (OR=17.73; 95% CI= 1.12 to 279.59; p=0.041). There is a positive correlation was statistically significant from family support with antiretroviral therapy adherence (OR=28.89; 95% CI= 1.24 to 647.71; p=0.036). Conclusion:The perception of the seriousness of the disease is the most variable bergubungan with antiretroviral therapy adherence (p=0.033).

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Section: The Relationship Between Know-supporting

confidence: 88%

Association between Knowledge, Perceived Seriousness, Perceived Benefit and Barrier, and Family Support on Adherence to Anti-Retrovirus Therapy in Patients with HIV/AIDS

Sunaryo¹,

Demartoto

Adriyani³

2016

J HEALTH PROMOT BEHAV

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“…The finding is in consonance with other studies. 6,12 Majority of patients (84.31%) were on non PI based regime. This finding is in accordance with other studies.…”

Section: Resultsmentioning

confidence: 99%

A study of utilization pattern of drugs in HIV positive patients at antiretroviral therapy centre of a tertiary care teaching hospital

Parmar

Sharma

Trivedi

2018

Int J Basic Clin Pharmacol

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Background: Infection with human immunodeficiency virus (HIV) and subsequent acquired immunodeficiency syndrome (AIDS) continues to be a major public health problem. Treatment and therapeutic guidelines have evolved over a period of time. Drug utilization study helps to evaluate changing pattern of drug use, compliance with national guidelines and rational use of drugs.Methods: Authors conducted observational, non interventional, descriptive study in outdoor HIV positive patients for one year. We have analysed collected data using descriptive statistics to determine drug use indicators and utilization pattern of drugs.Results: Study showed that average number of drugs per encounter was 3.96. The most commonly prescribed antiretroviral therapy (ART) regime was combination of zidovudine, lamivudine with nevirapine (51.92%). Among antiretroviral drugs prescribed, nucleoside reverse transcriptase inhibitors (49.45%) were the most common drug subclass and lamivudine (33.33%) was the most common antiretroviral drug. Second most common medication class was antibacterial agents (18.77%) and co-trimoxazole (10.11%) was the most common antibacterial agent. The third most commonly prescribed drug class was vitamins namely folic acid and multivitamins (2.63 %). Percentage of encounters with an antibiotic prescribed was 41.46%. Tuberculosis was the most common opportunistic infection. In 90.05% of encounters with ART prescriptions, adherence was more than 95%.Conclusions: Overall the results suggest that the prescribing pattern to be in accordance with national guidelines and reflect changing patterns of drug usage in HIV positive patients in World. Drug use indicators reflect rational approach to prescribing pattern.

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“…This low level of non-adherence to ART highlights the success of the national ART program in Kenya, where non-adherence levels are lower than reported in other sub-Saharan African countries, including: Rwanda, where 23% of ART patients were non-adherent based on 30-day recall [14]; Ghana, where 14% of ART patients were non-adherent [15]; rural Zambia where 40% of ART patients were not adherent [16], and a pooled analysis of African adherence studies, where overall non-adherence levels were reported to be 23% [17]. Data from developed countries also suggest higher non-adherence levels, with estimates of 45% in a pooled analysis of adherence studies in North America [17], 37% in Sweden [18], 34% in Brazil [19], and 43% in Spain [20].…”

Section: Discussionmentioning

confidence: 99%

Rates and Predictors of Non-Adherence to Antiretroviral Therapy among HIV-Positive Individuals in Kenya: Results from the Second Kenya AIDS Indicator Survey, 2012

et al. 2016

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IntroductionUnderstanding the levels and associated factors of non-adherence to antiretroviral therapy (ART) is crucial in designing interventions to improve adherence and health outcomes of ART. We assessed non-adherence to ART among HIV-infected persons reporting ART use in a nationally representative survey in Kenya.MethodsThe Kenya AIDS Indicator Survey 2012 was a population-based, household survey of persons aged 18 months-64 years conducted in 2012–2013. Self-reported information was collected on demographics, sexual behaviour, HIV status, and ART use. Blood was collected for HIV testing, and if HIV infected, CD4 and viral load testing. HIV-positive specimens were tested for the presence of antiretroviral (ARV) drugs using a qualitative ARV assay using liquid chromatography-tandem mass spectrometry. HIV-positive persons who reported receiving ART but did not have the ARV biomarker present were defined as being non-adherent to their ARV medication. We restricted our analysis to HIV-infected persons aged 15–64 years who reported receiving ART and had laboratory-confirmed results from ARV testing. Multivariate logistic regression was used to identify variables associated with non-adherence.ResultsA total of 648 (5.6%; CI 4.9–6.3) tested HIV-positive of whom 559 (86.3%) had sufficient volume of blood to be tested for ARV drugs. Of those, 271 (47.7%; CI 41.8–53.6) self-reported HIV-positive status during the interview and 186 (69.1%; CI 62.2–76.0) of those reported taking ART. The ARV biomarker was absent in 18 of 186 individuals (9.4%; CI 4.9–13.8) who thus were defined as being non-adherent to ART. Non-adherence was associated with being aged 15–29 years (AOR 8.39; CI 2.26–31.22, p = 0.002) compared to aged 30–64 years, rural residence (AOR 5.87; CI 1.39–25.61, p = 0.016) compared with urban residence and taking recreational drugs in the past 30 days (AOR 5.89; CI 1.30–26.70, p = 0.022).ConclusionOverall, less than 10% of Kenyans aged 15–64 years on ART were not adhering to their HIV medication, highlighting the success of the Kenyan national ART program. Our findings, however, point to the need for targeted interventions particularly for young persons, those in rural areas to improve adherence outcomes, as well as delivery of treatment programs that include psychosocial support as a preventative measure to minimize substance abuse and the risk of treatment failure.

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Predictors of Adherence to Antiretroviral Therapy among HIV/AIDS Patients in the Upper West Region of Ghana

Cited by 57 publications

References 8 publications

Association between Knowledge, Perceived Seriousness, Perceived Benefit and Barrier, and Family Support on Adherence to Anti-Retrovirus Therapy in Patients with HIV/AIDS

Association between Knowledge, Perceived Seriousness, Perceived Benefit and Barrier, and Family Support on Adherence to Anti-Retrovirus Therapy in Patients with HIV/AIDS

A study of utilization pattern of drugs in HIV positive patients at antiretroviral therapy centre of a tertiary care teaching hospital

Rates and Predictors of Non-Adherence to Antiretroviral Therapy among HIV-Positive Individuals in Kenya: Results from the Second Kenya AIDS Indicator Survey, 2012

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