Predictors of Axillary Lymph Node Metastases (ALNM) in a Korean Population with T1-2 Breast Carcinoma: Triple Negative Breast Cancer has a High Incidence of ALNM Irrespective of the Tumor Size

Lee, Jong Hoon; Kim, Sung Hwan; Suh, Young Jin; Shim, Byoung Yong; Kim, Hoon Kyo

doi:10.4143/crt.2010.42.1.30

Cited by 58 publications

(58 citation statements)

References 24 publications

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“…These findings were in accordance with previous reports [7][8][9][10][11][12][13]. Our study could not find out the association between molecular subtype and SLN metastasis, in contrast with previous reports [3,6,[14][15][16][17][18][19][20][21][22]. Possible explanation to the discrepancy between previous reports and our results is that the distribution in among subtype might affect the results: HER 2 type was very few (7.0%), and this seems to be the reason why low frequency of SLN metastasis in HER 2 subtype was shown in our study.…”

Section: Discussionsupporting

confidence: 87%

“…A lot of studies have elucidated several series of new tumor markers, however, axillary lymph node metastasis still has been a strong prognostic indicator for the patients with invasive breast cancer [1][2][3]. It is quite difficult to make exact diagnosis of node metastasis, especially, in T1-T2 breast cancer, therefore, sentinel lymph node (SLN) biopsy (SLNB) for clinically N0 breast cancer has already become a standard procedure [4].…”

Section: Introductionmentioning

confidence: 99%

“…A various clinicopathological factors have been identified as independent predictors of axillary lymph node metastasis in early stage breast cancer [6]. These include clinical palpability [7][8][9][10], tumor size [7][8][9][10][11][12][13], lymphatic or vascular involvement [7][8][9][10][11]13], tumor grade [7,10], hormone receptor (HR) status [12,13], age [8,11,12], and molecular subtypes [3,6,[14][15][16][17][18][19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%

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The Association between Sentinel Lymph Node Metastasis and Ki-67 Labeling Index

Koyama

Sakata²,

Sakata³

et al. 2013

ABCR

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Background: The purpose of this study was to elucidate the association between sentinel lymph node (SLN) metastasis and Ki67 labeling index and to elucidate whether Ki-67 was useful or not for prediction of SLN metastasis in breast cancer. Methods: We identified 343 invasive breast cancer patients with sentinel lymph node biopsy (SLNB) from 2003 to 2012. The association between SLN status and clinicopathological features, molecular subtypes and Ki-67 labeling index were evaluated. Results: SLN metastasis was detected in 79 patients (23.0%). SLN metastasis was significantly associated with clinical T-stage (p = 0.0003), lymphovascular involvement (LVI) (p < 0.0001). Ki-67 labeling index of primary tumor was significantly lower in SLN positive patients (p = 0.0331), and Ki-67 cut-off point of 7.5% was useful for dividing SLN positive from negative (p = 0.0197). Conclusion: Low value of Ki-67 labeling index, in addition to progression of clinical T-stage and presence of LVI, is significantly associated with SLN metastasis, and it seems to be useful to consider Ki-67 labeling index for SLN metastasis prediction.

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Section: Discussionsupporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Association between Sentinel Lymph Node Metastasis and Ki-67 Labeling Index

Koyama

Sakata²,

Sakata³

et al. 2013

ABCR

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“…The presence or absence of axillary lymph node involvement (ALNI) is the most important prognostic indicator for patients with early stage breast cancer (Rosen et al, 1993;Cianfrocca and Goldstein, 2004;Westenend et al, 2005;Lee et al, 2010). Increasing the number of involved axillary lymph nodes (ALN) is associated with an increased probability of recurrence and mortality (Colleoni et al, 2005).Efforts have been made to identify factors which can predict the risk of axillary lymph node involvement.…”

Section: Introductionmentioning

confidence: 99%

Predictive Role of Tumor Size in Breast Cancer with Axillary Lymph Node Involvement - Can Size of Primary Tumor be used to Omit an Unnecessary Axillary Lymph Node Dissection?

Orang

Marzony²,

Afsharfard³

2013

Asian Pacific Journal of Cancer Prevention

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Background: Breast cancer is the most common cancer among women worldwide. The aim of this study was to investigate the relationship between tumor size and axillary lymph node involvement (ALNI) in patients with invasive lesions, to find the best candidates for a full axillary dissection. Additionally, we evaluated the association between tumor size and invasive behavior. The study was based on data from 789 patients with histopathologically proven invasive breast cancer diagnosed in Shohada University hospital in Tehran, Iran (1993-2009). Cinical and histopathological characteristics of tumors were collected. Patients were divided into 6 groups according to primary tumor size: group I (0.1-≤1cm), II (1.1-≤2cm), III (2.1-≤3cm), IV (3.1-≤4cm), V (4.1-≤5cm) and VI (>5cm). The mean(±SD) size of primary tumor at the time of diagnosis was 3.59±2.69 cm that gradually declined during the course of study. There was a significant correlation between tumor size and ALNI (p<0.001). A significant positive correlation between primary tumor size and involvement of surrounding tissue was also found (p<0.001). The mean number of LNI in group VI was significantly higher than other groups (p<0.05).We observed more involvement of lymph nodes, blood vessels, skin and areola-nipple tissue with increase in tumor size.We found 15.3% overall incidence of ALNI in tumors ≤2 cm, indicating the need for more investigation to omit full axillary lymph node dissection with an acceptable risk for tumors below this diameter. While in patients with tumors ≥2 cm, 84.3% of them had nodal metastases, so the best management for this group would be a full ALND. Tumor size is a significant predictor of ALNM and involvement of surrounding tissue, so that an exact estimation of the size of primary tumor is necessary prior to surgery to make the best decision for management of patients with invasive breast cancer.

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“…However, one study by Iwase reported that triple negative patients were more frequently postmenopausal (16). Numerous studies indicated that in comparison with other cases, pathological grade of TNTs were higher (13,17,(20)(21)(22)(23) and Ki67 over expression was more common (8,9,14,20,21). In a retrospective cohort study on Korean breast cancer society registration program data, TNBC patients showed higher tumor size, lymphatic stage, histological grade, and more lymphovascular invasion.…”

Section: Discussionmentioning

confidence: 99%

A Survey in the Basal Like Breast Carcinoma Phenotype in North East of Iran

et al. 2017

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Background: Breast carcinoma is not a homogenous disease. It is divided into 5 pathological subtypes of luminal1, luminal2, strongly Her2 positive, basal like, and normal breast like. Basal like breast carcinoma that accounts for about 15% of all breast cancers has an aggressive clinical behavior with the features of high nuclear grade, negative estrogen receptor, progesterone receptor, and Her2 reactivity (triple negative). Objectives: We aimed at identifying the prevalence of basaloid phenotype among triple negative (TN) cases in our region via immunohistochemistry (IHC) staining using basaloid markers. Methods: We reviewed breast cancer patients in Omid and Imam Reza hospitals, Mashhad, Iran, between 2003 and 2007. We obtained the paraffin blocks from TN cases for immune-staining using cytokeratin 5/6 (CK5/6), cytokeratin 14 (CK14) and epidermal growth factor receptor1 (EGFR1) markers. Results: The incidence of TN disease among breast cancers was 21% (156/747). Based on IHC reactivity with at least one of the basaloid markers, from 59 available samples, 44 (75.4%) were basaloid. Conclusions: In our region, most triple negative tumors were basal like breast cancer (BLBC). Among these cases, most immunereactivity was observed for EGFR1, followed by CK14 and CK5/6.

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Predictors of Axillary Lymph Node Metastases (ALNM) in a Korean Population with T1-2 Breast Carcinoma: Triple Negative Breast Cancer has a High Incidence of ALNM Irrespective of the Tumor Size

Cited by 58 publications

References 24 publications

The Association between Sentinel Lymph Node Metastasis and Ki-67 Labeling Index

The Association between Sentinel Lymph Node Metastasis and Ki-67 Labeling Index

Predictive Role of Tumor Size in Breast Cancer with Axillary Lymph Node Involvement - Can Size of Primary Tumor be used to Omit an Unnecessary Axillary Lymph Node Dissection?

A Survey in the Basal Like Breast Carcinoma Phenotype in North East of Iran

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