Predictors of bronchial hyperresponsiveness in chronic rhinosinusitis with nasal polyp

Han, Doo Hee; Kim, S. W.; Cho, Sang Heon; Kim, Dong Young; Lee, C. H.; Kim, Sun Sin; Rhee, Chae‐Seo

doi:10.1111/j.1398-9995.2008.01841.x

Cited by 27 publications

(20 citation statements)

References 21 publications

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“…Han et al 10 2009 122 Tissue eosinophil (cells/HPF) The mean tissue eosinophil counts (p = 0.045) and serum eosinophil counts (p = 0.001) were higher in patients with CRSsNP with BHR group than non-BHR.…”

Section: Discussionmentioning

confidence: 95%

“…The cut-point at >0.30 × 10 9 /L or 4.4% of white blood cells as proposed is still within the normal range and has a negative predictive value of 67%. Han et al 10 also proposed the same cut-point of >0.30 × 10 9 /L for predicting bronchial hyperresponsiveness in CRSsNP with sensitivity of 70% and specificity of 70%. Sakuma et al 26 proposed the cut-point of ≥6% eosinophils of the total leukocytes for predicting ECRS with a sensitivity of 97.4% and a specificity of 70.7%.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Structured histopathology profiling of chronic rhinosinusitis in routine practice

Snidvongs

Lam

Sacks

et al. 2012

Int Forum Allergy Rhinol

197

264

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The diagnosis of ECRS has unique prognostic implications. Traditional features of the ECRS phenotype are not necessarily reliable markers for the presence of tissue eosinophilia. Serum eosinophilia may be a good surrogate marker of tissue eosinophilia but of limited use. The routine use of structured histopathology reporting in CRS is suggested, to allow for the diagnosis of ECRS and to identify other prognostic markers.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Structured histopathology profiling of chronic rhinosinusitis in routine practice

Snidvongs

Lam

Sacks

et al. 2012

Int Forum Allergy Rhinol

197

264

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show abstract

“…Further studies, such as a regression analysis in a larger cohort of Chinese patients with CRS, should be performed to better determine asthma risk and factors that contribute to asthma. 8 We conclude that Chinese patients with CRS have a low level of asthma comorbidity compared with Western populations. Further studies of the mechanisms of CRS and factors that contribute to asthma could improve management of the united airway.…”

Section: A Lower Prevalence Of Asthma Among Patients With Chronic Rhimentioning

confidence: 92%

A lower prevalence of asthma among patients with chronic rhinosinusitis in southern China

Fan

Chen

et al. 2011

Journal of Allergy and Clinical Immunology

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“…73 A later study demonstrated that sneezing and a serum eosinophil count of over 300 cells per microliter may be predictive factors for BHR in patients with CRSwNP. 74 We compared pulmonary function between CRS patients without any diagnosed lung diseases and healthy subjects. There were no significant differences between the two groups in terms of forced expiratory volume in 1 s and the percentage of predicted vital capacity.…”

Section: Presence and Characterization Of Comorbidity Of Chronic Rhinmentioning

confidence: 99%

Association and management of eosinophilic inflammation in upper and lower airways

Okano

Kariya

Ohta

et al. 2015

Allergology International

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This review discussed the contribution of eosinophilic upper airway inflammation includes allergic rhinitis (AR) and chronic rhinosinusitis (CRS) to the pathophysiology and course of asthma, the representative counterpart in the lower airway. The presence of concomitant AR can affect the severity of asthma in patients who have both diseases; however, it is still debatable whether the presence of asthma affects the severity of AR. Hypersensitivity, obstruction and/or inflammation in the lower airway can be detected in patients with AR without awareness or diagnosis of asthma, and AR is known as a risk factor for the new onset of wheeze and asthma both in children and adults. Allergen immunotherapy, pharmacotherapy and surgery for AR can contribute to asthma control; however, a clear preventive effect on the new onset of asthma has been demonstrated only for immunotherapy. Pathological similarities such as epithelial shedding are also seen between asthma and CRS, especially eosinophilic CRS. Abnormal sinus findings on computed tomography are seen in the majority of asthmatic patients, and asthmatic patients with CRS show a significant impairment in Quality of Life (QOL) and pulmonary function as compared to those without CRS. Conversely, lower airway inflammation and dysfunction are seen in non-asthmatic patients with CRS. Treatments for CRS that include pharmacotherapy such as anti-leukotrienes, surgery, and aspirin desensitization show a beneficial effect on concomitant asthma. Acting as a gatekeeper of the united airways, the control of inflammation in the nose is crucial for improvement of the QOL of patients with co-existing AR/CRS and asthma.

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Predictors of bronchial hyperresponsiveness in chronic rhinosinusitis with nasal polyp

Abstract: Taken together, these results indicate that moderate to severe sneezing and a serum eosinophil count > or = 300 cells/microl may be predictive factors for BHR in patients with CRSNP.

Cited by 27 publications

References 21 publications

Structured histopathology profiling of chronic rhinosinusitis in routine practice

Structured histopathology profiling of chronic rhinosinusitis in routine practice

A lower prevalence of asthma among patients with chronic rhinosinusitis in southern China

Association and management of eosinophilic inflammation in upper and lower airways

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