Predictors of delayed first voiding in newborn

Vuohelainen, Tuomo; Ojala, Riitta; Virtanen, Arja; Holm, Päivi; Tammela, Outi

doi:10.1111/j.1651-2227.2008.00809.x

Cited by 19 publications

(11 citation statements)

References 34 publications

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“…AVP is a neurophyseal peptide hormone which among other functions regulates fluid balance. In our two earlier studies we showed AVP hypersecretion to induce transient fluid retention in response to prolonged or otherwise stressful birth in healthy term infants [7], [8]. This stress response appears to be purposeful and is evidently physiological, unlike the fluid retention with VLBW infants observed in our present study.…”

Section: Introductionsupporting

confidence: 53%

Decreased Free Water Clearance Is Associated with Worse Respiratory Outcomes in Premature Infants

et al. 2011

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ObjectiveThe goal was to elucidate predictors of decreased free water clearance (DFWC) in very low birth weight (VLBW) infants. We hypothesized that DFWC and fluid retention are linked to the severity of pulmonary problems and prolonged respiratory support, especially to nCPAP treatment.MethodsThe investigation was carried out at Tampere University Hospital between 2001 and 2006. The study population comprised 74 VLBW infants born at 29.21 (24.57–34.14) weeks of gestation. Median birth weight was 1175 (575–1490) grams. We measured plasma and urine osmolality and 24-hour urine volume to calculate free water clearance (FWC) for each infant. If FWC was less than 30 ml/kg/day the infant was classified as having DFWC.ResultsThere were 38 (51.4%) infants with DFWC in the study population. The median duration of the observed DFT period was 14 (4–44) days. The gestational age at birth was lower for DFWC infants compared to infants with normal FWC (NFWC), 28.29 (24.57–32.86) vs. 30.00 (25.57–34.14) weeks (p = 0.001). DFWC infants also needed longer ventilator treatment, 2 (0–23) vs. 0.50 (0–23) days (p = 0.046), nCPAP treatment 30 (0–100) vs. 3 (0–41) days (p<0.0001) and longer oxygen supplementation 47 (0–163) vs. 22 (0–74) days (p = 0.011) than NFWC infants. All values presented here are medians with ranges.ConclusionsDFWC appears to be frequently connected with exacerbation and prolongation of pulmonary problems in VLBW infants. Cautious fluid administration seems to be indicated in VLBW infants with prolonged respiratory problems and DFWC.

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Section: Introductionsupporting

confidence: 53%

Decreased Free Water Clearance Is Associated with Worse Respiratory Outcomes in Premature Infants

et al. 2011

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“…Increased AVP levels at birth have been linked to delayed first voiding in newborns ( 93 , 115 ), and copeptin concentrations at birth are inversely related to postnatal weight loss by day 3 of life ( 86 ). Reducing urinary water loss at birth until the enteral supply picks with the establishment of lactation appears to be a prudent strategy, and cesarean section without any previous labor deprives the newborn infant of the wave of fetal AVP, which serves as a preemptive adaptation.…”

Section: Avp In Healthy Neonatesmentioning

confidence: 99%

Arginine Vasopressin and Copeptin in Perinatology

Evers

Wellmann

2016

Front. Pediatr.

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Arginine vasopressin (AVP) plays a major role in the homeostasis of fluid balance, vascular tonus, and the regulation of the endocrine stress response. The measurement of AVP levels is difficult due to its short half-life and laborious method of detection. Copeptin is a more stable peptide derived from the same precursor molecule, is released in an equimolar ratio to AVP, and has a very similar response to osmotic, hemodynamic, and stress-related stimuli. In fact, copeptin has been propagated as surrogate marker to indirectly determine circulating AVP concentrations in various conditions. Here, we present an overview of the current knowledge on AVP and copeptin in perinatology with a particular focus on the baby’s transition from placenta to lung breathing. We performed a systematic review of the literature on fetal stress hormone levels, including norepinephrine, cortisol, AVP, and copeptin, in regard to birth stress. Finally, diagnostic and therapeutic options for copeptin measurement and AVP functions are discussed.

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“…The natural delay of first voiding in newborns, [22][23][24][25] especially after prolonged complicated deliveries, 26 and our desire not to cause harm and avoid too many trials of urine sampling resulted in obtaining urine cultures only in 61% of the study group, three-quarters of them in the first 24 hours and only a quarter between 24 and 72 hours. The small number of positive urine cultures further limited our ability to draw definite conclusions, especially regarding possible differences in the rate of UTI in the first 24 versus the next 24 to 72 hours of life.…”

Section: Discussionmentioning

confidence: 99%

Is it Justified to Include Urine Cultures in Early (< 72 Hours) Neonatal Sepsis Evaluations of Term and Late Preterm Infants?

et al. 2012

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Predictors of delayed first voiding in newborn

Abstract: Delayed voiding appears to be related to a prolonged and stressful birth. Laboratory findings in the first urine suggest increased AVP and aldosterone secretion in such cases.

Cited by 19 publications

References 34 publications

Decreased Free Water Clearance Is Associated with Worse Respiratory Outcomes in Premature Infants

Decreased Free Water Clearance Is Associated with Worse Respiratory Outcomes in Premature Infants

Arginine Vasopressin and Copeptin in Perinatology

Is it Justified to Include Urine Cultures in Early (< 72 Hours) Neonatal Sepsis Evaluations of Term and Late Preterm Infants?

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