Predictors of Depression and Anxiety in Patients with Intracranial Neoplasms

Appleby, Brian S.; Appleby, Kristin K.; Rabins, M.P.H. Peter V.

doi:10.1176/jnp.2008.20.4.447

Cited by 7 publications

(3 citation statements)

References 16 publications

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“…As shown in Table 2, potential targets for PAT are the depression, anxiety, and SUD that are common, under-reported, and often undertreated in patients with brain tumors, stroke, SAH, TBI, spinal cord injury, chronic spinal disability, other pain syndromes, and Parkinson disease. 3,4,76-104 For example, psilocybin-assisted therapy may help some of these patients gain greater acceptance of their disability, reduce apathy, and promote living more fully. 82,83…”

Section: Mood Disorders and Addictionmentioning

confidence: 99%

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Psychedelic-Assisted Therapy and Psychedelic Science: A Review and Perspective on Opportunities in Neurosurgery and Neuro-Oncology

et al. 2022

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After a decades-long pause, psychedelics are again being intensely investigated for treating a wide range of neuropsychiatric ailments including depression, anxiety, addiction, post-traumatic stress disorder, anorexia, and chronic pain syndromes. The classic serotonergic psychedelics psilocybin and lysergic acid diethylamide and nonclassic psychedelics 3,4-methylenedioxymethamphetamine and ketamine are increasingly appreciated as neuroplastogens given their potential to fundamentally alter mood and behavior well beyond the time window of measurable exposure. Imaging studies with psychedelics are also helping advance our understanding of neural networks and connectomics. This resurgence in psychedelic science and psychedelic-assisted therapy has potential significance for the fields of neurosurgery and neuro-oncology and their diverse and challenging patients, many of whom continue to have mental health issues and poor quality of life despite receiving state-of-the-art care. In this study, we review recent and ongoing clinical trials, the set and setting model of psychedelic-assisted therapy, potential risks and adverse events, proposed mechanisms of action, and provide a perspective on how the safe and evidence-based use of psychedelics could potentially benefit many patients, including those with brain tumors, pain syndromes, ruminative disorders, stroke, SAH, TBI, and movement disorders. By leveraging psychedelics' neuroplastic potential to rehabilitate the mind and brain, novel treatments may be possible for many of these patient populations, in some instances working synergistically with current treatments and in some using subpsychedelic doses that do not require mind-altering effects for efficacy. This review aims to encourage broader multidisciplinary collaboration across the neurosciences to explore and help realize the transdiagnostic healing potential of psychedelics.

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Section: Mood Disorders and Addictionmentioning

confidence: 99%

“…NA, not available; SUD, substance use disorders.aSUD includes for alcohol, opioids, and/or nicotine.Refer to references: 76-104 .…”

Section: Mood Disorders and Addictionmentioning

confidence: 99%

Psychedelic-Assisted Therapy and Psychedelic Science: A Review and Perspective on Opportunities in Neurosurgery and Neuro-Oncology

et al. 2022

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“…The open syncmer sketch is suitable for the MinHash algorithm for full k-mer sets As highlighted earlier, the MinHash and FracMinHash algorithms both utilize a bottom sketch strategy: they use a single hash function to uniformly and randomly project arbitrary k-mers into hash space to select elements by hash values instead of using a family of min-wise independent hash functions to select elements separately [3]. In metagenomic analysis, the single hash manner is mostly used for computational efficiency, and hash functions from murmurhash [1] family are popular choices.…”

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confidence: 99%

Connecting Syncmers to FracMinHash: similarities and advantages

Liu,

Koslicki

2023

Preprint

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MotivationSketching methods provide scalable solutions for analyzing rapidly growing genomic data. A recent innovation in sketching methods, syncmers, has proven effective and has been employed for read alignment. Syncmers share fundamental features with the FracMinHash technique, a recent modification of the popular MinHash algorithm for set similarity estimation between sets of different sizes. While previous researchers have demonstrated the effectiveness of syncmers in read alignment, their potential for use in genomic analysis (for which FracMinHash was designed) has not been fully realized.ResultsWe demonstrate that the open syncmer sketch is equivalent to a FracMinHash sketch when applying tok-mer-based similarities, yet it exhibits superior distance distribution and genomic coverage. Moreover, we can expand the concept ofk-mer truncation to open syncmers, enabling multi-resolution estimation in metagenomics as well as flexible-sized seeding for sequence comparisons.ReproducibilityAll analysis scripts can be found onGitHub.

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