Predictors of Depressive Relapse in Women Undergoing Infertility Treatment

Freeman, Marlene P.; Lee, Hang; Savella, Gina M.; Sosinsky, Alexandra Z.; Marfurt, Samantha P; Murphy, Shannon; Cohen, Lee S.

doi:10.1089/jwh.2017.6878

Cited by 15 publications

(14 citation statements)

References 36 publications

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“…Moreover, further evidence has demonstrated a direct link between inflammatory processes and rMDD [17]. For instance, Freeman et al demonstrated that CRP levels were associated with depression relapse (odds ratio = 1.92; 95% confidence interval 1.43–2.55; p < 0.0001), suggesting that inflammation contributes to the risk of relapse [33]. Copeland et al also demonstrated that cumulative episodes predict changes in CRP levels independently, although body mass index, nicotine use, and recent infections were partial mediators of the effect of cumulative episodes on CRP levels [34].…”

Section: Link Between Inflammation and Rmddmentioning

confidence: 99%

Role of inflammation in depression relapse

Liu

Zhang

et al. 2019

J Neuroinflammation

120

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Major depressive disorder (MDD) is a leading cause of disability worldwide. After the first episode, patients with remitted MDD have a 60% chance of experiencing a second episode. Consideration of therapy continuation should be viewed in terms of the balance between the adverse effects of medication and the need to prevent a possible relapse. Relapse during the early stages of MDD could be prevented more efficiently by conducting individual risk assessments and providing justification for continuing therapy. Our previous work established the neuroimaging markers of relapse by comparing patients with recurrent major depressive disorder (rMDD) in depressive and remitted states. However, it is not known which of these markers are trait markers that present before initial relapse and, consequently, predict disease course. Here, we first describe how inflammation can be translated to subtype-specific clinical features and suggest how this could be used to facilitate clinical diagnosis and treatment. Next, we address the central and peripheral functional state of the immune system in patients with MDD. In addition, we emphasize the important link between the number of depressive episodes and rMDD and use neuroimaging to propose a model for the latter. Last, we address how inflammation can affect brain circuits, providing a possible mechanism for rMDD. Our review suggests a link between inflammatory processes and brain region/circuits in rMDD.

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Section: Link Between Inflammation and Rmddmentioning

confidence: 99%

Role of inflammation in depression relapse

Liu

Zhang

et al. 2019

J Neuroinflammation

120

View full text Add to dashboard Cite

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“…We did not find any clinical trial specifically investigating the effects of hormonal treatments on depressive symptoms in unipolar or bipolar disorder patients. In a recent prospective observational study that included women receiving infertility treatments with a history of major depressive disorder or bipolar disorder (24), a high risk of depressive relapse was found, even in those women maintaining psychotropic medication. These results suggest that maintenance of medication is not sufficient to avoid affective relapses.…”

Section: Discussionmentioning

confidence: 99%

“…Pregnant women did not differ in depressive symptoms compared to the other two groups, suggesting a lack of negative effect of fertility treatments on psychopathological symptoms. More recently, Freeman et al (24) carried out a prospective observational study in women with a previous history of unipolar or bipolar depression undergoing fertility treatment (24). They concluded that maintenance of psychotropic medication was not sufficient for avoiding affective recurrences.…”

Section: Introductionmentioning

confidence: 99%

Women Undergoing Hormonal Treatments for Infertility: A Systematic Review on Psychopathology and Newly Diagnosed Mood and Psychotic Disorders

et al. 2020

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Background: The association between infertility treatments and mental disorders has been poorly addressed. This work aims to review current evidence on the psychopathological effects of hormonal treatments used for infertility on women and the occurrence of newly diagnosed mood and psychotic disorders.Methods: A systematic review was performed by searching PubMed and clinicaltrials.gov databases from inception until September 2019. Clinical trials on hormone treatments for infertility in patients with mood or psychotic disorders, as well as those evaluating the onset of symptoms, were included. Selected studies were published in English, Spanish, and Dutch language peer-reviewed journals. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed. Observational studies and case reports were excluded. Effect sizes for changes in depressive symptoms were calculated with Hedges'g and Cohen's d confidence intervals. A meta-analysis was not performed due to the heterogeneity of hormonal compounds in protocols.Results: From 1,281 retrieved records, nine trials were included; all of them were conducted in non-clinical populations. Four trials compared Gonadotropin-releasing hormone (GnRH) agonists and GnRH antagonists, showing a better mood profile for hormonal protocols including antagonists in one trial. Two trials compared protocols using GnRH agonists/antagonists versus natural cycle protocols (without gonadotropin stimulation), with a better mood profile (less depressive symptoms) in those protocols

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“…Association between psychological stress(such as depression and anxiety) and male or female infertility has been reported [14,15] , and the impact of psychological stress on women has been well analyzed [16][17][18] ]. However, the association of psychological stress and male semen parameters has not yet been fully studied [19] .…”

Section: Introductionmentioning

confidence: 99%

Association of Anxiety With Sperm Quality: a Multicentre Cross-sectional Study in China During the COVID-19 Outbreak

Wang

Yang

et al. 2021

Preprint

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Objectives: There is no report about association of anxiety on sperm quality during the COVID-19 epidemic. Purpose of this study was to investigate the relationship between anxiety and sperm quality during the COVID-19 outbreak in China.Methods: 896 sperm donors from 7 sperm banks in China were investigated, and passed the screening for sperm donation between 23 January 2020 and 8 June 2020. Semen quality analysis follows the standards of the WHO Fifth Edition Human Semen Examination and Processing Manual. Anxiety symptoms were assessed by the Generalized Anxiety Disorder Scal-7(GAD-7). Logistic regression and linear regression were used to identify the association between anxiety level and sperm quality.Results: Participants with anxiety status (N = 155; 17.3%) had lower sperm concentration (56.81 ± 32.70 vs. 47.21 ± 30.76 [106/mL]), sperm volume (3.58 ± 1.65 vs. 3.04 ± 1.69 [mL], P < 0.001), total sperm count (7.29 ± 1.23 vs. 6.56 ± 1.63 [106], P < 0.001), and progressive motility (50.86 ± 12.45 vs. 38.50 ± 17.00 [%], P < 0.001) than those without anxiety. Linear regression showed that anxiety symptoms was significantly associated with 8.13 (95% confidence interval [CI]: 2.51, 13.75), 0.49 (0.20, 0.79) ,51.05 (23.43, 78.68) and 12.15 (95% CI: 23.43, 78.68), reduction in sperm concentration, semen volume, and total sperm count and progressive motility respectively.Conclusions: This study revealed that anxiety symptoms were negatively associated with semen quality, and interaction was discovered between debt stress and anxiety.

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Predictors of Depressive Relapse in Women Undergoing Infertility Treatment

Cited by 15 publications

References 36 publications

Role of inflammation in depression relapse

Role of inflammation in depression relapse

Women Undergoing Hormonal Treatments for Infertility: A Systematic Review on Psychopathology and Newly Diagnosed Mood and Psychotic Disorders

Association of Anxiety With Sperm Quality: a Multicentre Cross-sectional Study in China During the COVID-19 Outbreak

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