Predictors of Diabetes Self-Management in Older Adults Receiving Chemotherapy

Hershey, Denise Soltow; Given, Barbara; Given, Charles W.; Corser, William; Eye, Alexander von

doi:10.1097/ncc.0b013e3182888b14

Cited by 17 publications

(29 citation statements)

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“…For patients with comorbid cancer and diabetes, the adverse outcomes highlighted in this review include higher mortality rates [36], consistent with findings in several studies [7,8,11,16] and poor adherence to DM medications [31,34,35] as reported by Hershey and colleagues [11]. …”

Section: Discussionsupporting

confidence: 84%

“…Consequences include: increased mortality [7,8], higher infection rates [9,10], higher hospitalisation rates [10], worse physical function [11] and poorer prognosis [12,9]. Potential reasons for these poorer outcomes include: prioritising cancer treatments over DM self-management activities [11,13]; increased prevalence of and/or under recognition of hyperglycaemia [14]; and clinicians lacking skills in managing both these complex conditions [14,15]. Sub-optimal DM management during cancer care can result in worsened glycaemic control [13].…”

Section: Introductionmentioning

confidence: 99%

“…Sub-optimal DM management during cancer care can result in worsened glycaemic control [13]. This has been associated with lower overall survival [11,16] and may be explained, to some extent, by increased deaths from cardiovascular disease [17] and obesity.…”

Section: Introductionmentioning

confidence: 99%

“…One paper found that adherence to glucose lowering drugs decreased in patients following cancer diagnosis [21]. To improve outcomes for patients with both cancer and DM, health professionals need a greater understanding of the impact cancer treatment has on glycaemic control and concomitant DM self-management activities [11,13]. Consequently, this review was undertaken to answer the following question:…”

Section: Introductionmentioning

confidence: 99%

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Glycaemic control in people with type 2 diabetes mellitus during and after cancer treatment: A systematic review and meta-analysis

et al. 2017

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BackgroundCancer and Diabetes Mellitus (DM) are leading causes of death worldwide and the prevalence of both is escalating. People with co-morbid cancer and DM have increased morbidity and premature mortality compared with cancer patients with no DM. The reasons for this are likely to be multifaceted but will include the impact of hypo/hyperglycaemia and diabetes therapies on cancer treatment and disease progression. A useful step toward addressing this disparity in treatment outcomes is to establish the impact of cancer treatment on diabetes control.AimThe aim of this review is to identify and analyse current evidence reporting glycaemic control (HbA1c) during and after cancer treatment.MethodsSystematic searches of published quantitative research relating to comorbid cancer and type 2 diabetes mellitus were conducted using databases, including Medline, Embase, PsychINFO, CINAHL and Web of Science (February 2017). Full text publications were eligible for inclusion if they: were quantitative, published in English language, investigated the effects of cancer treatment on glycaemic control, reported HbA1c (%/mmols/mol) and included adult populations with diabetes. Means, standard deviations and sample sizes were extracted from each paper; missing standard deviations were imputed. The completed datasets were analysed using a random effects model. A mixed-effects analysis was undertaken to calculate mean HbA1c (%/mmols/mol) change over three time periods compared to baseline.ResultsThe available literature exploring glycaemic control post-diagnosis was mixed. There was increased risk of poor glycaemic control during this time if studies of surgical treatment for gastric cancer are excluded, with significant differences between baseline and 12 months (p < 0.001) and baseline and 24 months (p = 0.002).ConclusionWe found some evidence to support the contention that glycaemic control during and/or after non-surgical cancer treatment is worsened, and the reasons are not well defined in individual studies. Future studies should consider the reasons why this is the case.

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Section: Discussionsupporting

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Glycaemic control in people with type 2 diabetes mellitus during and after cancer treatment: A systematic review and meta-analysis

et al. 2017

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“…Overall, the importance of comorbidities has not been well established in older patients with AML. However, it has been shown that AML cancer survivors who have comorbid disease(s) experience lower levels of QOL, (45) have poorer physical function, and less able to self-manage their disease (46). The assessment of comorbidities prior to treatment is critically important to better facilitate choice of treatment options.…”

Section: Comorbidity Measures In Amlmentioning

confidence: 99%

Comorbidity, Physical Function, and Quality of Life in Older Adults with Acute Myeloid Leukemia

2017

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Purpose of review To describe the pathology, impact of comorbidities, functional limitations, symptoms, and quality of life (QOL) related to treatment of acute myeloid leukemia (AML) in older adults. Recent findings AML is a rare aggressive hematologic disease that occurs most often in older adults. The prognosis for older patients with AML is markedly worse due to genetic mutations and patient characteristics such as comorbidities and functional limitations. Patient characteristics may influence treatment decisions, as well as impact symptoms, functional ability, health-related outcomes and (QOL). Summary As the population continues to age, the number of people diagnosed with AML is expected to increase. Better management of comorbidities is imperative to improving QOL and other treatment related outcomes. Prospective, longitudinal and multi-site studies are warranted to further understand the interaction between these characteristics on symptoms, outcomes and QOL.

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Glycemic control in people with diabetes treated with cancer chemotherapy: contribution of continuous glucose monitoring

et al. 2023

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Predictors of Diabetes Self-Management in Older Adults Receiving Chemotherapy

Abstract: Oncology nurses need to be aware of the impact cancer treatment can have on the performance of diabetes self-management activities in adults. Future research needs to test interventions that may assist patients with diabetes and cancer in managing both diseases.

Cited by 17 publications

References 50 publications

Glycaemic control in people with type 2 diabetes mellitus during and after cancer treatment: A systematic review and meta-analysis

Glycaemic control in people with type 2 diabetes mellitus during and after cancer treatment: A systematic review and meta-analysis

Comorbidity, Physical Function, and Quality of Life in Older Adults with Acute Myeloid Leukemia

Glycemic control in people with diabetes treated with cancer chemotherapy: contribution of continuous glucose monitoring

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