Predictors of distant metastasis in parotid acinic cell carcinoma

Fang, Qigen; Wu, Junhua; Du, Wei; Zhang, Xu

doi:10.1186/s12885-019-5711-4

Cited by 30 publications

(44 citation statements)

References 28 publications

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“…The authors subsequently concluded that END should be reserved for high grade tumours and for those with larger primary tumours. This viewpoint was also supported by other investigators [29, 30]. In the current study, we found that the rate of occult neck metastasis was 27.8% for early stage parotid SCC, while previous authors described a variable occult metastasis rate from 41 to 60% [8].…”

Section: Discussionsupporting

confidence: 90%

Oncologic outcome and potential prognostic factors in primary squamous cell carcinoma of the parotid gland

Fang

Liu

2019

BMC Cancer

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s Background Primary parotid squamous cell carcinoma (SCC) is an uncommon tumour, and there is limited data on its prognosis and treatment. The goal of the current study was to analyse the potential prognostic factors and clinical outcomes for this tumour type. Methods Consecutive patients with surgically treated primary parotid SCC were retrospectively enrolled in this study. The primary end point was locoregional control (LRC) and disease-specific survival (DSS), which were calculated by the Kaplan-Meier method. Independent prognostic factors were evaluated by the Cox proportional hazards method. Results In total, 53 patients were included for analysis. Perineural and lymphovascular invasion were observed in 21 and 16 patients, respectively. Intraparotid node (IPN) metastasis was reported in 23 patients with an incidence rate of 43.3%. Twenty-six patients with cN0 disease underwent neck dissection, and pathologic node metastasis was observed in 10 cases. The 5-year LRC and DS S rates were 35 and 49%, respectively. The Cox model was used to report the independence of disease stage and IPN metastasis in predicting LRC and the independence of disease stage and perineural invasion in predicting DSS. Conclusions The prognosis of primary parotid SCC is relatively unfavourable. IPN metastasis significantly decreases disease control, disease stage is the most important prognostic factor, and neck dissection is suggested for patients at any stage.

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Section: Discussionsupporting

confidence: 90%

Oncologic outcome and potential prognostic factors in primary squamous cell carcinoma of the parotid gland

Fang

Liu

2019

BMC Cancer

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“…In a previous study, Védrine et al (7) reported that differences in OS, DSS, and RFS rates were not statistically significant between primary and secondary MEC groups; only 18 patients were included in their research. Verma et al (27) reviewed 58 cases of secondary MEC in PubMed and reported that the 5-year RFS and OS rates were 95 and 93.4%, respectively, which were slightly better than our outcomes. One possible explanation was that there is much more bias in calculating the survival rates based on case reports worldwide.…”

Section: Figure 2 |contrasting

confidence: 75%

“…However, there were only 18 cases included in the analysis in this study, and this small sample size might greatly decrease its persuasiveness. Recently, Verma et al (27) reviewed 58 cases of secondary salivary MEC. These authors found that the parotid gland was most likely to be involved, that 87.5% of the diseases were low or intermediate grade, and that most of the patients were staged as T1 or T2.…”

Section: Figure 2 |mentioning

confidence: 99%

Comparison Between Primary and Secondary Pediatric Mucoepidermoid Carcinoma of the Head and Neck

Shi

2020

Front. Pediatr.

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Objectives: Secondary mucoepidermoid carcinoma (MEC) of the head and neck is occasionally observed in childhood cancer survivors. The goal of this research was to compare the demographic and pathologic characteristics, as well as survival between primary and secondary MEC in children and adolescent patients. Methods: Pediatric patients (younger than 19 years old) with surgically treated MEC of the head and neck were retrospectively enrolled at the Affiliated Children's Hospital of Zhengzhou University and divided into two groups based on their cancer history. Demographic, pathologic, and survival characteristics between the two groups were compared. The main study interests were recurrence-free survival (RFS), overall survival (OS), and disease-specific survival (DSS). Results: The primary and secondary groups consisted of 63 and 15 patients, respectively. The two groups had similar distributions in terms of age, sex, tumor stage, neck lymph node stage, perineural invasion, lymphovascular invasion, p53, Bcl-2, proliferating cell nuclear antigen, carcinoembryonic antigen, and Ki-67 index. The 10-year RFS rates for the primary group and secondary group were 80 and 71%, respectively, and this difference was not significant (p = 0.464). The 10-year DSS rates for the primary group and secondary group were 83 and 82%, respectively, and this difference was also not significant (p = 0.649). The 10-year OS rates for the primary group and secondary group were 74 and 51%, respectively; this difference was significant (p = 0.023). Further Cox model analysis confirmed the independence of a previous cancer history (p = 0.043) in decreasing OS. Conclusions: Pediatric patients with secondary MEC exhibit similar demographic, pathologic, and molecular characteristics as primary patients but worse OS. These findings indicate that special disease management approaches might be needed for secondary patients.

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“…The surgical technique required for SMG preservation is not a concerning matter [ 13 ], and our head and neck department performs nearly 5000 operations every year; thus, our rich experience enables us to face many difficulties [ 24 , 25 , 27 – 30 ]. The biggest problem involves clearing any possible lymph nodes around the SMG.…”

Section: Discussionmentioning

confidence: 99%

Impact of submandibular gland preservation in neck management of early-stage buccal squamous cell carcinoma on locoregional control and disease-specific survival

Fang

Yao

et al. 2020

BMC Cancer

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Background The feasibility of submandibular gland (SMG) preservation in oral squamous cell carcinoma (SCC) has occasionally been analyzed, but the differences in survival associated with the presence or absence of SMG preservation remain unknown. We aimed to prospectively evaluate the oncologic results of SMG preservation in cT1-2 N0 buccal SCC. Methods This was a prospective, non-randomized cohort study. Patients with surgically treated cT1-2 N0 buccal SCC were prospectively enrolled and divided into two groups based on the management of the SMG. Level 1b lymph nodes were categorized into six groups based on the positional relationship between the lymph node and the SMG. The main study endpoints were locoregional control (LRC) and disease-specific survival (DSS). Results A total of 31 of the 137 included patients underwent SMG-sparing neck dissection. Patients with SMG preservation were likely to be young persons. Superior metastasis occurred in 11 patients with a prevalence of 8.0%, followed by an anterior metastasis rate of 5.1%, and no metastases developed deeply or within the SMG. The 5-year LRC rates in the SMG-sparing and SMG-excision groups were 74 and 75%, respectively, and the difference was not significant (p = 0.970). The 5-year DSS rates in the SMG-sparing and SMG-excision groups were 74 and 69%, respectively, and the difference was not significant (p = 0.709). Conclusions SMG involvement was rare, and the superior group carried the highest risk for lymph node metastasis. SMG-sparing neck dissection is selectively suggested in cT1-2 N0 buccal SCC patients, and could avoid postoperative asymmetric appearance and dry mouth.

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Predictors of distant metastasis in parotid acinic cell carcinoma

Cited by 30 publications

References 28 publications

Oncologic outcome and potential prognostic factors in primary squamous cell carcinoma of the parotid gland

Oncologic outcome and potential prognostic factors in primary squamous cell carcinoma of the parotid gland

Comparison Between Primary and Secondary Pediatric Mucoepidermoid Carcinoma of the Head and Neck

Impact of submandibular gland preservation in neck management of early-stage buccal squamous cell carcinoma on locoregional control and disease-specific survival

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