Predictors of distress in female breast cancer survivors: a systematic review

Syrowatka, Ania; Motulsky, Aude; Kurteva, Siyana; Hanley, James A.; Dixon, William G; Meguerditchian, Ari N.; Tamblyn, Robyn

doi:10.1007/s10549-017-4290-9

Cited by 188 publications

(188 citation statements)

References 66 publications

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“…The identification of survivors who are at an increased risk of a higher symptom burden will facilitate more timely symptom management interventions . In a recent systematic review that evaluated the demographic and clinical characteristics associated with higher distress in survivors of breast cancer, younger age, being nonwhite, being unmarried, and being of lower socioeconomic status were the consistent demographic characteristics identified. In terms of clinical characteristics, having a higher number of comorbidities and functional limitations as well as receipt of CTX, less time since the completion of treatment, and disease recurrence were found to be associated with higher levels of distress.…”

Section: Introductionmentioning

confidence: 99%

Perceived stress is associated with a higher symptom burden in cancer survivors

Mazor

Paul

Chesney

et al. 2019

Cancer

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Background Although multiple co‐occurring symptoms are a significant problem for cancer survivors, to the authors' knowledge little is known regarding the phenotypic characteristics associated with a higher symptom burden. The objectives of the current study were to evaluate the occurrence, severity, and distress associated with 32 symptoms and examine the phenotypic and stress characteristics associated with a higher symptom burden. Methods A total of 623 cancer survivors completed a demographic questionnaire, as well as measures of functional status, comorbidity, and global (Perceived Stress Scale) and cancer‐related (Impact of Event Scale–Revised) stress. The Memorial Symptom Assessment Scale was used to evaluate symptom burden. Multiple linear regression analysis was used to determine the phenotypic characteristics associated with a higher symptom burden. Results The mean number of symptoms was 9.1 (±5.2). The most common, severe, and distressing symptoms were lack of energy, problems with sexual interest/activity, and hair loss, respectively. Poorer functional status, a higher level of comorbidity, and a history of smoking as well as higher Perceived Stress Scale and Impact of Event Scale–Revised scores were associated with a higher symptom burden. The overall model explained approximately 45.6% of the variance in symptom burden. Conclusions Although cancer survivors report a high number of co‐occurring symptoms of moderate severity and distress, in the current study, no disease or treatment characteristics were found to be associated with a higher symptom burden. Clinicians need to assess for general and disease‐specific stressors and provide referrals for stress management interventions. Future studies need to examine the longitudinal relationships among symptom burden, functional status, and level of comorbidity, as well as the mechanisms that underlie the associations between stress and symptom burden.

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Section: Introductionmentioning

confidence: 99%

Perceived stress is associated with a higher symptom burden in cancer survivors

Mazor

Paul

Chesney

et al. 2019

Cancer

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“…Furthermore, the present study showed that the FBSI indexes were to a lesser degree in correlation with depression and stress symptomatology, although they were closely correlated with anxiety in comparison with TOI indexes. Because cancer as a chronic condition confers the risk of psychological problems for the patients (21)(22)(23), the FBSI indexes may be seen useful in delineating the psychosocial factors associated with the breast cancer symptoms, which may foster or hamper the patients' QoL.…”

Section: Discussionmentioning

confidence: 99%

The Validation of Functional Assessment of Cancer Therapy-Breast Symptom Index (FBSI) Among Iranian Women with Breast Cancer

et al. 2020

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Background: Patient-reported outcomes (PROs) are widely utilized in research and clinical practice. The functional assessment of cancer therapy-breast cancer (FACT-B) provides effective indexes addressing different dimensions of quality of life (QoL) in patients with breast cancer. Objectives: The study aimed at evaluating the validity of the functional assessment of cancer therapy-breast symptom index (FBSI-6 and -8) on Iranian patients. Methods: Overall, 223 patients from three cancer centers participated in the present study. Internal consistency was assessed via Cronbach's alpha and inter-item correlations. Spearman's rho correlation was utilized to evaluate convergent/divergent validity and performance of the target indexes in terms of psychosocial distress, compared to trial outcome index-physical/functional/breast (TOI-PFB), as well as TOI emotional/social/breast (TOI-ESB) cancer subscales. The known-groups analysis, using Mann-Whitney U and Kruskal-Wallis tests, was conducted based on the history of metastasis, chemotherapy, radiotherapy, mastectomy, and time since diagnosis. P value < 05 was considered significant. Results: Both of the target indexes showed acceptable internal consistency. They were highly correlated with physical wellbeing and TOI-PFB, moderately with functional wellbeing and breast cancer subscale, lowly with the arm subscale, and very lowly with social wellbeing (P < 0.0001). All indexes showed significant and negative correlations with distress symptoms (P < 0.0001). The FBSI-8 slightly outperformed FBSI-6 in terms of distress symptoms. No significant differences were seen in the target indexes based on clinical characteristics, including metastasis, chemotherapy, radiotherapy, mastectomy surgery, and time since diagnosis. Conclusions: The current study confirmed the validity of FBSI-6 and -8 among Iranian women with breast cancer. Further research is required to evaluate the more profound properties of FBSI.

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“…The number of cancer survivors has increased over time, allowing individuals to live longer after their diagnosis . Depression is a very commonly observed comorbid condition among cancer survivors . Generally, cancer survivors have a higher risk of depression, and sometimes depression results in suicide in cancer patients .…”

Section: Discussionmentioning

confidence: 99%

“…1,2 Depression is a very commonly observed comorbid condition among cancer survivors. [4][5][6] Generally, cancer survivors have a higher risk of depression, and sometimes depression results in suicide in cancer patients. [7][8][9] The findings of this study reveal that 22% of cancer survivors in the sample reported having a history of depression diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…1 The prevalence of depression in cancer survivors is increasing and is a disabling condition that constitutes an important public health problem in the US as well as globally. [4][5][6] The most common behavioral sequelae of breast and other cancer include fatigue, sleep disturbance, cognitive impairment, and depression. 7 Depression in cancer survivors is not uncommon.…”

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confidence: 99%

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