Predictors of duodenal bulb biopsy performance in the evaluation of coeliac disease in children

Tanpowpong, Pornthep; Broder‐Fingert, Sarabeth; Katz, Aubrey J.; Camargo, Carlos A.

doi:10.1136/jclinpath-2012-200874

Cited by 7 publications

(6 citation statements)

References 22 publications

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“…Of the total patients included in this systematic review and meta-analysis, 47.46 % (n = 1922) were diagnosed with celiac disease based upon a positive biopsy result from any location in the duodenum. Fourteen studies found biopsy of the duodenal bulb to increase the diagnostic yield of celiac disease 10 11 12 17 18 19 20 22 23 24 25 27 29 30 A total of three included studies demonstrated no improvement in diagnostic accuracy of celiac disease with duodenal bulb biopsy 21 26 28 .…”

Section: Resultsmentioning

confidence: 99%

“…This meta-analysis included a total of 17 studies 10 11 12 17 18 19 20 21 22 23 24 25 26 27 28 29 30 . A PRISMA flow chart of search results is shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

“…Fourteen prospective and three retrospective studies were included. All three retrospective studies examined pediatric populations 18 21 22 . No randomized controlled trials were found and included in this systematic review and meta-analysis.…”

Section: Resultsmentioning

confidence: 99%

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Efficacy of duodenal bulb biopsy for diagnosis of celiac disease: a systematic review and meta-analysis

et al. 2018

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Background and study aims Although duodenal biopsy is considered the “gold standard” for diagnosis of celiac disease, the optimal location of biopsy within the small bowel for diagnosis remains unclear. The primary aim of this study was to perform a structured systematic review and meta-analysis to evaluate the diagnostic utility of endoscopic duodenal bulb biopsy for celiac disease. Patients and methods Searches of PubMed, EMBASE, Web of Science, and Cochrane Library databases were performed from 2000 through December 2017. Review of titles/abstracts, full review of potentially relevant studies, and data abstraction was performed. Measured outcomes of adult and pediatric patients included location of biopsy, mean number of biopsies performed, and diagnosis of celiac disease as defined by the modified Marsh-Oberhuber classification. Results A total of 17 studies (n = 4050) were included. Seven studies evaluated adults and 11 studies assessed pediatric populations. Mean age of adults and pediatric patients was 46.70 ± 2.69 and 6.33 ± 1.26 years, respectively. Overall, sampling from the duodenal bulb demonstrated a 5 % (95 % CI 3 – 9; P < 0.001) increase in the diagnostic yield of celiac disease. When stratified by pediatric and adult populations, duodenal bulb biopsy demonstrated a 4 % (95 % CI: 1 to 9; P < 0.001) and 8 % (95 % CI: 6 to 10; P < 0.001) increase in the diagnostic yield of celiac disease. Non-celiac histologic diagnoses including Brunner gland hyperplasia and peptic duodenitis were reported more commonly in the duodenal bulb as compared to the distal duodenum with an increase in diagnostic yield of 4 % (95 % CI 3 – 5; P < 0.001) and 1 % (95 % CI 1 – 2; P < 0.001), respectively. Conclusions Based upon our results, biopsy and histologic examination of duodenal bulb during routine upper endoscopy increases the diagnostic yield of celiac disease.

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Section: Resultsmentioning

confidence: 99%

“…This meta-analysis included a total of 17 studies 10 11 12 17 18 19 20 21 22 23 24 25 26 27 28 29 30 . A PRISMA flow chart of search results is shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

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Efficacy of duodenal bulb biopsy for diagnosis of celiac disease: a systematic review and meta-analysis

et al. 2018

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“…Thus, multiple biopsies from different sites in the proximal small bowel are recommended [35]. A very elevated TTG IgA titer or a moderately elevated TTG IgA titer in the setting of a high antiendomysium IgA potentially may lead to the diagnosis of CD in symptomatic adults without duodenal biopsy [36].…”

Section: Testingmentioning

confidence: 99%

Cystic Fibrosis and Celiac Disease

Pohl¹,

Lowichik²,

Cantrell³

2015

Diet and Exercise in Cystic Fibrosis

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“…Несмотря на достигнутые результаты, в полной мере рас-крыть механизмы восстановления гистоархитектоники слизистой оболочки до сих пор не удается. Существенным недостатком большинства проведенных исследований является видение проблемы регенерации ткани в основ-ном через призму иммунологических и иммуноморфо-логических аспектов [7,8]. Лишь в единичных работах по изучению регенерации слизистой оболочки тонкой кишки упомянуто о наличии кооперации клеточных попу-ляций, способных формировать полноценные эпителиаль-но-миоцито-стромальные взаимодействия, обеспечивая, таким образом, структурную целостность и функциональ-ную состоятельность органа в целом.…”

Section: обоснованиеunclassified

Regeneration Process Markers in Hyperregenerative Type of Small Intestinal Mucosal Atrophy

Кузнецова¹,

Широкова²,

Бугров³

et al. 2015

Vopr. sovr. pediatr.

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Predictors of duodenal bulb biopsy performance in the evaluation of coeliac disease in children

Abstract: The authors found a significant increase in DBB performance over time, but the overall performance remains suboptimal. Improving education on obtaining a DBB for CD evaluation is crucial, especially among those children in whom DBB is more likely to be omitted.

Cited by 7 publications

References 22 publications

Efficacy of duodenal bulb biopsy for diagnosis of celiac disease: a systematic review and meta-analysis

Efficacy of duodenal bulb biopsy for diagnosis of celiac disease: a systematic review and meta-analysis

Cystic Fibrosis and Celiac Disease

Regeneration Process Markers in Hyperregenerative Type of Small Intestinal Mucosal Atrophy

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