Today organizations have confronted a dynamic environment and open-end changes from the VUCA world; they must always competitively struggle to change themselves to increase operational efficiency, financial effectiveness, and strategic capabilities development for survival. Along with changes, they must maintain customer satisfaction and employee engagement in a manner with limited resources. Therefore, understanding the nature of organizational change, and the mechanisms of effectively managing change so that organizations can successfully achieve the goals of change is a vital field for management. For the question, the paper adopted the methodology of the exploratory approach; it examined the literature to present the dimensions and characteristics of organizational change and change management. To integrate all findings from the exploratory study into a unified form, the authors propose a system-based framework for managing organizational change, that hopes to help organizations increase their change success ratio when applying to their own contexts, especially in their digital transformation, which is considered the most complex, open-end and holistic change nowadays.