Predictors of fatigue following the onset of infectious mononucleosis

Candy, Bridget; Chalder, Trudie; Cleare, Anthony J.; Peakman, A.; Skowera, Ania; Wessely, Simon; Weinman, John; Zuckerman, Mark; Hotopf, Matthew

doi:10.1017/s0033291703007554

Cited by 78 publications

(44 citation statements)

References 24 publications

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“…Studies focusing on fatigue in specific groups at risk found no predictive role of cortisol in the development of post-infectious unexplained fatigue in 71 primary care patients after 3 or 6 months [41], or in postoperative unexplained fatigue in 161 patients undergoing elective surgery after two days, three weeks, or six months [42]. From a study on fatigue in the general population, however, another picture emerges.…”

Section: Do Alterations In Hpa Axis Activity Precede Fsd?mentioning

confidence: 99%

Dysfunction of stress responsive systems as a risk factor for functional somatic syndromes

Tak

Rosmalen

2010

Journal of Psychosomatic Research

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The etiology of functional somatic syndromes or disorders (FSDs) is generally considered to be a multifactorial interplay between psychological, biological, and social factors. One of the most investigated biological factors is stress responsive system dysfunction. Despite more than twenty years of research of the autonomic nervous system and the hypothalamic-pituitary-adrenal axis, however, it is yet unknown whether dysfunctions in these systems play a causal role in the etiology of FSDs and whether they are generic or FSD-specific. In this review, we will give an overview of available evidence on whether or not alterations in these stress responsive systems can be considered causal risk factors of FSDs. We conclude that although not necessary factors for FSDs in general, lowered cardiac vagal activity and hypocortisolism may be pivotal in the etiology and treatment strategy in subgroups of subjects with a FSD. Such subgroups need to be better identified.

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Section: Do Alterations In Hpa Axis Activity Precede Fsd?mentioning

confidence: 99%

Dysfunction of stress responsive systems as a risk factor for functional somatic syndromes

Tak

Rosmalen

2010

Journal of Psychosomatic Research

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“…The literature gives ample evidence of chronic fatigue syndromes after infections with viruses like Epstein-Barr virus [1], Ross River virus [2], Coxiella burnetii [3,4], and enterovirus [5,6]. However, also noninfectious diseases have been associated with chronic fatigue such as rheumatic arthritis [7], cancer [8,9], or Crohn's disease [10].…”

Section: Introductionmentioning

confidence: 99%

Post-inflammatory fatigue in sarcoidosis: Personality profiles, psychological symptoms and stress hormones

Korenromp

Grutters

Bosch

et al. 2012

Journal of Psychosomatic Research

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“…The finding that the more pronounced the HPA axis changes, the longer the CFS, supports the latter assertion [30]. Furthermore, two prospective studies of groups at high risk of developing chronic fatigue (post-EBV infection and post-surgery) found that the development of fatigue 6 months after was not associated with any HPA axis changes [31,32]. However, one study [33] suggested the opposite, showing that a subset of healthy regular exercisers developed pain and fatigue after being experimentally deprived of exercise for 1 week, and these individuals had lower HPA axis function at the baseline of the experiment.…”

Section: Pharmacological Treatmentsmentioning

confidence: 62%

Herbal Drugs in Chronic Fatigue Syndrome: An Overview

Semalty

Panda

et al. 2012

Schweiz Z Ganzheitsmed

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Chronic fatigue syndrome (CFS) is a debilitating and complex disorder characterized by profound fatigue of 6 months or longer duration that is not improved by bed rest and that may be worsened by physical or mental activity. It is often age-related and may coexist with other diseases such as multiple sclerosis, Parkinson’s disease, depression, cancer, HIV infection etc. Persons with CFS most often function at a substantially lower level of activity than they were capable of before the onset of illness. Modern medicine has limited therapies and those offered by it have strong side-effects. On the other hand, various traditional systems of medicine such as the Chinese herbal system and Ayurveda offer several botanicals, especially the adaptogens, which have been used to combat chronic fatigue effectively. Literature reports a plethora of animal and clinical studies on the safety and efficacy of these plant drugs. The present article extensively reviews CFS, its pathophysiology, and its pharmacological treatment, with a special emphasis on herbal drugs such as Cat’s claw, Ginseng, caterpillar fungus, ashwagandha, Tulsi, jiaogulan etc. The botanical therapies discussed here are very commonly used drugs with profound data available on them.

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Predictors of fatigue following the onset of infectious mononucleosis

Cited by 78 publications

References 24 publications

Dysfunction of stress responsive systems as a risk factor for functional somatic syndromes

Dysfunction of stress responsive systems as a risk factor for functional somatic syndromes

Post-inflammatory fatigue in sarcoidosis: Personality profiles, psychological symptoms and stress hormones

Herbal Drugs in Chronic Fatigue Syndrome: An Overview

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