Predictors of Future Atrial Fibrillation Development in Patients with Hypertrophic Cardiomyopathy: A Prospective Follow‐Up Study

Tülüce, Kamil; Tülüce, Selcen Yakar; Eren, Nihan Kahya; Kocabaş, Uğur; Akçay, Filiz Akyıldız; Gündüz, Ramazan; Akyıldız, Zehra İlke; Ergene, Oktay

doi:10.1111/echo.13093

Cited by 20 publications

(17 citation statements)

References 31 publications

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“…23,24 This is consistent with our observation that left atrial size was an independent predictor of incident AF. It has also been shown that age and congestive symptoms are independent predictors of AF occurrence.…”

Section: Discussionsupporting

confidence: 92%

Clinical Correlates and Prognostic Value of Elevated Right Atrial Pressure in Patients With Hypertrophic Cardiomyopathy

McCullough

Fifer

Mohajer

et al. 2018

Circ J

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Background:The clinical characteristics associated with elevated right atrial pressure (RAP) in hypertrophic cardiomyopathy (HCM) are unknown. Few data exist as to whether elevated RAP has prognostic implications in patients with HCM. This study investigated the clinical correlates and prognostic value of elevated RAP in HCM. Methods and Results:This retrospective cohort study was performed on 180 patients with HCM who underwent right heart catheterization between 1997 and 2014. Elevated RAP was defined as >8 mmHg. Baseline characteristics, mean pulmonary artery pressure, and mean pulmonary capillary wedge pressure (PCWP) were assessed for association with elevated RAP. The predictive value of elevated RAP for all-cause mortality and the development of atrial fibrillation (AF), ventricular tachycardia/fibrillation (VT/VF), and stroke was evaluated. Elevated RAP was associated with higher New York Heart Association class, dyspnea on exertion, orthopnea, edema, jugular venous distention, larger left atrial size, right ventricular hypertrophy, higher pulmonary artery pressure, and higher PCWP. RAP independently predicted all-cause mortality (adjusted hazard ratio [aHR] 2.18 per 5-mmHg increase, 95% confidence interval [CI] 1.05-4.50, P=0.04) and incident AF (aHR 1.85 per 5-mmHg increase, 95% CI 1.20-2.85, P=0.005). Elevated RAP did not predict VT/VF (P=0.36) or stroke (P=0.28). Conclusions:Elevated RAP in patients with HCM is associated with left-sided heart failure and is an independent predictor of all-cause mortality and new-onset AF.

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Section: Discussionsupporting

confidence: 92%

Clinical Correlates and Prognostic Value of Elevated Right Atrial Pressure in Patients With Hypertrophic Cardiomyopathy

McCullough

Fifer

Mohajer

et al. 2018

Circ J

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“…Atrial enlargement implies loss of normal architecture and generation of new electric circuits that predispose to the development of AF. This finding has been repeated in several studies using atrial dimension instead of atrial area . Our study is the first to consider a cutoff value for the atrial area, a parameter that is much more used in clinical practice than atrial dimension.…”

Section: Discussionsupporting

confidence: 62%

“…This finding has been repeated in several studies using atrial dimension instead of atrial area. 1,4,16,17 Our study is the first to consider a cutoff value for the atrial area, a parameter that is much more used in clinical practice than atrial dimension. The value of 28 cm 2 was found a good parameter to predict the development of AF.…”

Section: Discussionmentioning

confidence: 99%

E/eʹ ratio and left atrial area are predictors of atrial fibrillation in patients with hypertrophic cardiomyopathy

et al. 2018

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“…Hypertrophic Cardiomyopathy: PWD together with LA phasic functions, and N-Terminal Pro-Brain Natriuretic Peptide (NT-proBNP) levels, predict development of AF [22].…”

Section: Normal Limit Values Of P-wave Dispersion (Pwd)mentioning

confidence: 99%

P-wave dispersion: an update

Pérez‐Riera

Abreu

Barbosa‐Barros

et al. 2016

Indian Pacing and Electrophysiology Journal

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P-wave dispersion (PWD, Pd or Pdis) is a noninvasive electrocardiographic (ECG) marker for atrial remodeling and predictor for atrial fibrillation (AF). PWD is defined as the difference between the widest and the narrowest P-wave duration recorded from the 12 ECG leads. Increased P-wave duration and PWD reflect prolongation of intraatrial and interatrial conduction time with lack of a well-coordinated conduction system within the atrial muscles, with inhomogeneous, asynchronic, pro-inflammatory and anti-inflammatory effect mediated by interleukin-6 (IL-6) in patients with the CG + GG genotype IL-6 -634C/G polymorphism [1] and discontinuous propagation of sinus impulses mainly between the left and right atria, interstitial/extracellular fibroblast activation and collagen deposition with fibrosis (via TGF-β) in atrial tissue, insufficient blood supply, significant not isotropic myoelectric activity, and thin wall thickness and consequent expansion tendency all well-known electrophysiological characteristics in patients with atrial arrhythmias and especially paroxysmal atrial fibrillation (PAF) [2].

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Predictors of Future Atrial Fibrillation Development in Patients with Hypertrophic Cardiomyopathy: A Prospective Follow‐Up Study

Cited by 20 publications

References 31 publications

Clinical Correlates and Prognostic Value of Elevated Right Atrial Pressure in Patients With Hypertrophic Cardiomyopathy

Clinical Correlates and Prognostic Value of Elevated Right Atrial Pressure in Patients With Hypertrophic Cardiomyopathy

E/eʹ ratio and left atrial area are predictors of atrial fibrillation in patients with hypertrophic cardiomyopathy

P-wave dispersion: an update

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