Predictors of health-related quality of life in Parkinson's disease

Kuhlman, G. M.; Flanigan, Joseph L.; Sperling, Scott A.; Barrett, Matthew J.

doi:10.1016/j.parkreldis.2019.05.009

Cited by 93 publications

(95 citation statements)

References 27 publications

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“…Our study indicated that EDS, evaluated by the ESS, was different among the three groups. In addition, consistent with previous studies that investigated the impacts of EDS on QoL (Kuhlman et al, 2019;Xiang et al, 2019;Yoo et al, 2019), we found that EDS was an important contributor to QoL in all PD patients. It was reported that EDS was independently correlated to cognitive impairment in PD (Marinus et al, 2018).…”

Section: Discussionsupporting

confidence: 92%

“…Different from the result that motor function showed the greatest effects on the QoL of PD-NC patients, depression, which was assessed by the GDS in this study, had the strongest impact on the QoL of PD-MCI and PDD patients. A series of studies reported that depression was the main and most frequently identified contributor of QoL for patients with PD (Winter et al, 2010(Winter et al, , 2011Hinnell et al, 2012;Lawson et al, 2014Lawson et al, , 2016Fereshtehnejad et al, 2015;van Uem et al, 2018;Kuhlman et al, 2019). Consistent with the other two studies (Kadastik-Eerme et al, 2015;Ophey et al, 2018), we also found that depression was the most critical determinant of QoL in all PD patients, emphasizing the impacts of depression.…”

Section: Discussionsupporting

confidence: 90%

“…PD is incurable at present, and the improvement or maintenance of QoL is an important objective of treatment and care in PD patients (Martinez-Martin, 2017). Accruing studies have reported that both motor symptoms and NMS make significant contributions to QoL in PD patients (Hinnell et al, 2012;Wu et al, 2014;Kuhlman et al, 2019). Cognitive impairment has also been shown to be correlated with poor QoL (Lawson et al, 2014(Lawson et al, , 2016.…”

Section: Introductionmentioning

confidence: 99%

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Determinants of Quality of Life According to Cognitive Status in Parkinson’s Disease

Fan

Liang

et al. 2020

Front. Aging Neurosci.

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Background: Quality of life (QoL) was worse in Parkinson's disease patients with mild cognitive impairment (PD-MCI) or dementia (PDD) than PD patients with normal cognition (PD-NC). The aim of this study was to investigate and compare the potential heterogeneous determinants of QoL in PD patients with different cognitive statuses. Methods: We recruited 600 PD patients, including 185 PD-NC patients, 336 PD-MCI patients and 79 PDD patients, in this cross-sectional study. All patients completed the QoL assessment by the 39-item Parkinson's Disease Questionnaire (PDQ-39), as well as clinical evaluations and neuropsychological tests. The determinants of the QoL were analyzed by multiple stepwise regression analysis. Results: QoL was more impaired across the three groups (PD-NC < PD-MCI < PDD). The Unified Parkinson's Disease Rating Scale part III (UPDRS-III) score, Geriatric Depression Rating Scale (GDS) score and daily levodopa equivalent dose (LED) were independent variables of PDQ-39 in PD-NC patients. The GDS score, disease duration, UPDRS-III score, Epworth Sleepiness Score (ESS) and sex were independent variables of PDQ-39 in PD-MCI patients. The GDS score and disease duration were independent variables of PDQ-39 in PDD patients. Conclusion: The determinants of QoL in PD-NC, PD-MCI and PDD patients were heterogeneous. Motor function was considered to be the most crucial determinant for QoL in PD-NC, while depression was indicated to be the most vital determinant for PD-MCI and PDD. For QoL improvement, clinicians might need to focus more on motor function in PD-NC patients and on depression in PD-MCI and PDD patients.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

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Determinants of Quality of Life According to Cognitive Status in Parkinson’s Disease

Fan

Liang

et al. 2020

Front. Aging Neurosci.

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“…Non-motor symptoms (NMS) are prevalent in PD, even early in the disease course and have a negative impact on health-related quality of life [33]. Among these, cognitive dysfunction is estimated to be present in 205 to 40% of patients with early PD and up to 47% with normal baseline cognition develop cognitive impairment at six years follow up [34,35].…”

Section: Osa and Cognitive Function In Pdmentioning

confidence: 99%

Obstructive Sleep Apnea in Neurodegenerative Disorders: Current Evidence in Support of Benefit from Sleep Apnea Treatment

Lajoie

Lafontaine

Kimoff

et al. 2020

JCM

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Obstructive sleep apnea (OSA) is a prevalent disorder characterized by recurrent upper airway obstruction during sleep resulting in intermittent hypoxemia and sleep fragmentation. Research has recently increasingly focused on the impact of OSA on the brain’s structure and function, in particular as this relates to neurodegenerative diseases. This article reviews the links between OSA and neurodegenerative disease, focusing on Parkinson’s disease, including proposed pathogenic mechanisms and current knowledge on the effects of treatment.

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“…Assessing quality of life (QOL) has moved to the forefront of clinical research and practice in PD [4,5]. e assessment of QOL is important because it can help identify the aspects of a patient's functioning that are affected by his or her disease and that are potential problems that need to be addressed during treatment.…”

Section: Introductionmentioning

confidence: 99%

Validation of an Individualized Measure of Quality of Life, Patient Generated Index, for Use with People with Parkinson’s Disease

Kuspinar

Mate

Lafontaine

et al. 2020

Neurology Research International

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Introduction. Parkinson’s disease (PD) affects all aspects of an individual’s life and is heterogeneous across people and time. The Patient Generated Index (PGI) is an individualized measure of quality of life (QOL) that allows patients to identify the areas of life that are important to them. Although the PGI has immense potential for use in clinical and research settings, its validity has not been assessed in PD. The purpose of this study is to estimate how well areas of QOL that patients with PD nominate on the PGI agree with ratings obtained from standard outcome measures. Methods. Patients with PD completed the PGI and various standard patient-reported outcome (PRO) measures. The PGI and standard PRO measures were compared at the total score, domain, and item levels. Pearson’s correlations and independent t-tests were used, as well as positive and negative predictive values. Results. The sample (n = 76) had a mean age of 69 (standard deviation 9) and were predominantly men (59%). The PGI was moderately correlated (r = −0.35) with the standardized disease-specific QOL measure Parkinson’s Disease Questionnaire (PDQ-8). Within one severity rating, agreement between the PGI and different standard outcome measures ranged from 85 to 100% for walking, 69 to 100% for fatigue, 38 to 75% for depression, and 20 to 80% for memory/concentration. Conclusion. This study demonstrates that nominated areas of QOL on the PGI provide comparable results to standard PRO measures, and provides evidence in support of the validity of this individualized measure in PD.

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Predictors of health-related quality of life in Parkinson's disease

Cited by 93 publications

References 27 publications

Determinants of Quality of Life According to Cognitive Status in Parkinson’s Disease

Determinants of Quality of Life According to Cognitive Status in Parkinson’s Disease

Obstructive Sleep Apnea in Neurodegenerative Disorders: Current Evidence in Support of Benefit from Sleep Apnea Treatment

Validation of an Individualized Measure of Quality of Life, Patient Generated Index, for Use with People with Parkinson’s Disease

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