Predictors of health status and health-related quality of life 12 months after severe burn

Wasiak, Jason; Lee, Stuart; Paul, Eldho; Mahar, Patrick; Pfitzer, B; Spinks, Anneliese; Cleland, Heather; Gabbe, Belinda

doi:10.1016/j.burns.2014.01.021

Cited by 81 publications

(61 citation statements)

References 24 publications

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“…Most patients were recruited during or after a treatment in a (pediatric) hospital ( n = 21), while others were selected from a specialized burn center ( n = 2) [20, 28], sports center ( n = 1) [23], or nursing home facility ( n = 1) [30]. …”

Section: Resultsmentioning

confidence: 99%

“…The remaining studies used the Pediatric Quality of Life Inventory (PedsQL, n = 3) [19, 22, 25], or a combination of the EQ-5D and SF-36 ( n = 1) [44]. The majority of the studies assessed the participants’ pre-injury HRQL by using a questionnaire ( n = 16) [18, 20, 22–24, 27, 28, 31–33, 35, 37, 41, 44–46] or a face-to-face interview ( n = 11) [8, 21, 25, 29, 30, 34, 36, 38–40]. At follow-up, most studies used questionnaires ( n = 17) [18, 23, 24, 27, 28, 31–33, 35, 37, 39–41, 44–47] followed by the use of telephone interviews ( n = 10) [19, 21, 22, 25, 26, 30, 34, 36, 42, 43].…”

Section: Resultsmentioning

confidence: 99%

“…The focus of the questionnaire and/or interviews (i.e., a specified period prior to the injury) was often not specifically defined (e.g., “before the injury,” n = 15) or not reported ( n = 2) [28, 38]. The studies that specified the period of their pre-injury assessment used a day before injury ( n = 1) [31], “just” before injury ( n = 1) [30], a week before injury ( n = 4) [25, 39, 45], the previous week ( n = 2) [23, 29], or the month or four weeks before injury ( n = 3) [20, 24, 26].…”

Section: Resultsmentioning

confidence: 99%

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Assessment of pre-injury health-related quality of life: a systematic review

Scholten

Haagsma

Beeck

et al. 2017

Popul Health Metrics

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BackgroundInsight into the change from pre- to post-injury health-related quality of life (HRQL) of trauma patients is important to derive estimates of the impact of injury on HRQL. Prospectively collected pre-injury HRQL data are, however, often not available due to the difficulty to collect these data before the injury. We performed a systematic review on the current methods used to assess pre-injury health status and to estimate the change from pre- to post-injury HRQL due to an injury.MethodsA systematic literature search was conducted in EMBASE, MEDLINE, and other databases. We identified studies that reported on the pre-injury HRQL of trauma patients. Articles were collated by type of injury and HRQL instrument used. Reported pre-injury HRQL scores were compared with general age- and gender-adjusted norms for the EQ-5D, SF-36, and SF-12.ResultsWe retrieved results from 31 eligible studies, described in 41 publications. All but two studies used retrospective assessment and asked patients to recall their pre-injury HRQL, showing widely varying timings of assessments (soon after injury up to years after injury). These studies commonly applied the SF-36 (n = 13), EQ-5D (n = 9), or SF-12 (n = 3) using questionnaires (n = 14) or face-to-face interviews (n = 11). Two studies reported prospective pre-injury assessment, based on prospective longitudinal cohort studies from a sample of initially non-injured patients, and applied questionnaires using the SF-36 or SF-12. The recalled pre-injury HRQL scores of injury patients consistently exceeded age- and sex-adjusted population norms, except in a limited number of studies on injury types of higher severity (e.g., traumatic brain injury and hip fractures). All studies reported reduced post-injury HRQL compared to pre-injury HRQL. Both prospective studies reported that patients had recovered to their pre-injury levels of physical and mental health, while in all but one retrospective study patients did not regain the reported pre-injury levels of HRQL, even years after injury.ConclusionsSo far, primarily retrospective research has been conducted to assess pre-injury HRQL. This research shows consistently higher pre-injury HRQL scores than population norms and a recovery that lags behind that of prospective assessments, implying a systematic overestimation of the change in HRQL from pre- to post-injury due to an injury. More prospective research is necessary to examine the effect of recall bias and response shift. Researchers should be aware of the bias that may arise when pre-injury HRQL is assessed retrospectively or when population norms are applied, and should use prospectively derived HRQL scores wherever possible to estimate the impact of injury on HRQL.Electronic supplementary materialThe online version of this article (doi:10.1186/s12963-017-0127-3) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Assessment of pre-injury health-related quality of life: a systematic review

Scholten

Haagsma

Beeck

et al. 2017

Popul Health Metrics

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“…Several studies have reported that, over time, the HRQoL of burn patients approaches the HRQoL levels of the general population [9][10][11][12]. However, in those burn patients reporting lower HRQoL larger total body surface area (TBSA) [9,11,12], presence of mental disorders such as major depression [9] or PTSD [10], and higher pain levels [12] are important determining factors.…”

mentioning

confidence: 97%

Health-related quality of life (EQ-5D) early after injury predicts long-term pain after burn

Gauffin

Öster

Sjöberg

et al. 2016

Burns

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“…4 Although several studies have questioned the validity of a sexual dimorphism for trauma patients in general, 5,6 the findings within the burn population has remained consistent across time and between different populations. 7-10 …”

Section: Introductionmentioning

confidence: 99%

Effects of Estrogen on Bacterial Clearance and Neutrophil Response After Combined Burn Injury and Wound Infection

Plackett

Deburghraeve

Palmer

et al. 2016

Journal of Burn Care & Research

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Objective Females have a higher rate of mortality following burn injury, largely due to differences in sepsis-related mortality. The present study seeks to understand the underpinnings of the estrogen’s immunomodulatory effects in a murine model of burn injury and infection. Methods Gonad-intact and ovariectomized female mice were subjected to a 15% total body surface area scald injury and then inoculated with 3,000 CFU of Pseudomonas aeruginosa by topical application to the wound. Animals were sacrificed at 1, 2, or 7 days after injury. Tissue and whole blood were collected. Cultures were performed of all tissues to assess for bacteria content. Lungs were examined for histologic appearance and homogenates were analyzed for chemokines and myeloperoxidase activity. Results Mortality reached 95% by 3 days after injury for gonad intact mice, whereas in ovariectomized mice it was 76% at 7 days. Blood and tissue samples from gonad intact mice had significantly higher levels of Pseudomonas aeruginosa compared to ovariectomized mice. Histologic assessment of lungs demonstrated a similar overall cellularity in ovariectomized mice relative to gonad intact mice 1 day after injury, but increased neutrophil count in gonad intact mice. This correlated with chemotactic signaling as lung homogenates had lower levels of KC in ovariectomized mice (128.0±19.8 vs 48.3±5.7 pg/mg protein). Also, myeloperoxidase was significantly lower in lung homogenates of ovariectomized mice (1.12±0.34 vs 0.56±0.08 units/mg protein). Conclusions Ovariectomy confers an early, but brief survival advantage in female mice after burn injury and wound infection. This appears to be secondary to enhanced bacterial clearance

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Predictors of health status and health-related quality of life 12 months after severe burn

Cited by 81 publications

References 24 publications

Assessment of pre-injury health-related quality of life: a systematic review

Assessment of pre-injury health-related quality of life: a systematic review

Health-related quality of life (EQ-5D) early after injury predicts long-term pain after burn

Effects of Estrogen on Bacterial Clearance and Neutrophil Response After Combined Burn Injury and Wound Infection

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