Predictors of Hospital-Acquired Clostridioides difficile Infection: A Systematic Review

Puro, Neeraj; Joseph, Reena; Zengul, Ferhat; Cochran, Kenneth J; Camins, Bernard; Ray, Midge N.

doi:10.1097/jhq.0000000000000236

Cited by 6 publications

(2 citation statements)

References 42 publications

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“…reduction of the risk of complications associated with the use of antibiotics: various forms of mycosis, incidence of nosocomial diarrhea of Clostridioides difficile etiology [ 12 , 13 ];…”

Section: Discussionmentioning

confidence: 99%

Preliminary trial of 24 vs 72 hour perioperative meropenem in patients with ESBL-producing Enterobacterales bacteriuria scheduled for urological procedures

Radko

Guzek

Syryło

et al. 2022

Cent european J Urol

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Introduction Antimicrobial prophylaxis is an important issue in positive urine culture patients undergoing endourological procedures or extracorporeal shock wave lithotripsy (ESWL). It is especially recognized in asymptomatic bacteriuria patients of alarm pathogen etiology. We designed a preliminary study to determine optimal duration of antibiotic prophylaxis in patients undergoing endourological procedures or ESWL with asymptomatic bacteriuria caused by Enterobacterales with extended spectrum beta-lactamase positive (ESBL+) type resistance. Material and methods A total of 60 patients with confirmed ESBL+ Enterobacterales bacteriuria were admitted for endourological procedures or ESWL. The patients were randomized into two groups – a one-day (n = 33) and a three-day (n = 27) period of perioperative antibiotic prophylaxis with meropenem. In both groups on the following day after the procedure (24 hours after the procedure) and 7 days after the procedure serum inflammation markers were assessed. Results Values of white blood count, C-reactive protein and procalcitonin prior to, 24 hours and seven days after the procedure clearly showed no statistically significant differences between groups that have received a one-day and three-day antibiotic regimen. Conclusions In patients with ESBL+ Enterobacterales asymptomatic bacteriuria undergoing endourological procedures or ESWL a 72-hour perioperative meropenem prophylaxis showed no superiority over a 24-hour regimen. Further studies will be carried out to establish optimal prophylaxis for specific endourological procedures and to test safety of a single dose regimen.

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“…reduction of the risk of complications associated with the use of antibiotics: various forms of mycosis, incidence of nosocomial diarrhea of Clostridioides difficile etiology [ 12 , 13 ];…”

Section: Discussionmentioning

confidence: 99%

Preliminary trial of 24 vs 72 hour perioperative meropenem in patients with ESBL-producing Enterobacterales bacteriuria scheduled for urological procedures

Radko

Guzek

Syryło

et al. 2022

Cent european J Urol

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“…Although we know of no published systematic reviews of scoring systems/models, numerous independent risk factors for CDI have been described, including patient level, medication-related, and organizational features (Table 1: risk factors for CDI) [12]. Translating known risk factors into an individualized, quantified estimate of iCDI risk for patients requires development and validation of a risk prediction tool.…”

Section: Predictive Modeling: Overviewmentioning

confidence: 99%

Can prediction scores be used to identify patients at risk of Clostridioides difficile infection?

Rao

Dubberke

2021

Current Opinion in Gastroenterology

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Purpose of reviewTo describe the current state of literature on modeling risk of incident and recurrent Clostridioides difficile infection (iCDI and rCDI), to underscore limitations, and to propose a path forward for future research. Recent findingsThere are many published risk factors and models for both iCDI and rCDI. The approaches include scores with a limited list of variables designed to be used at the bedside, but more recently have also included automated tools that take advantage of the entire electronic health record. Recent attempts to externally validate scores have met with mixed success. SummaryFor iCDI, the performance largely hinges on the incidence, which even for hospitalized patients can be low (often <1%). Most scores fail to achieve high accuracy and/or are not externally validated. A challenge in predicting rCDI is the significant overlap with risk factors for iCDI, reducing the discriminatory ability of models. Automated electronic health record-based tools show promise but portability to other centers is challenging. Future studies should include external validation and consider biomarkers to augment performance.

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Organizational and infrastructural risk factors for health care–associated Clostridioides difficile infections or methicillin-resistant Staphylococcus aureus in hospitals

Wang,

Garrod,

Duncombe

et al. 2024

American Journal of Infection Control

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Predictors of Hospital-Acquired Clostridioides difficile Infection: A Systematic Review

Cited by 6 publications

References 42 publications

Preliminary trial of 24 vs 72 hour perioperative meropenem in patients with ESBL-producing Enterobacterales bacteriuria scheduled for urological procedures

Preliminary trial of 24 vs 72 hour perioperative meropenem in patients with ESBL-producing Enterobacterales bacteriuria scheduled for urological procedures

Can prediction scores be used to identify patients at risk of Clostridioides difficile infection?

Organizational and infrastructural risk factors for health care–associated Clostridioides difficile infections or methicillin-resistant Staphylococcus aureus in hospitals

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