Predictors of hospitalization for respiratory failure among patients with sarcoidosis‐associated pulmonary hypertension

Gayen, S.; Mamary, A.J.

doi:10.1002/pul2.12212

Cited by 1 publication

(2 citation statements)

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“…It showed that 60% of sarcoid patients with PH were hospitalized at least once for respiratory failure before LTx or death. Treatment with vasodilators was significantly associated with a 80% decrease in risk of hospitalization [105]. This important finding might be taken into account in therapeutic decision making for SAPH patients, in whom guidelines are presently poorly validated.…”

Section: Discussionmentioning

confidence: 82%

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Sarcoidosis-Associated Pulmonary Hypertension

Israël-Biet,

Pastré,

Nunes

2024

JCM

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Sarcoidosis-associated pulmonary hypertension (SAPH) is a very severe complication of the disease, largely impacting its morbidity and being one of its strongest predictors of mortality. With the recent modifications of the hemodynamic definition of pulmonary hypertension (mean arterial pulmonary pressure >20 instead of <25 mmHg,) its prevalence is presently not precisely known, but it affects from 3 to 20% of sarcoid patients; mostly, although not exclusively, those with an advanced, fibrotic pulmonary disease. Its gold-standard diagnostic tool remains right heart catheterization (RHC). The decision to perform it relies on an expert decision after a non-invasive work-up, in which echocardiography remains the screening tool of choice. The mechanisms underlying SAPH, very often entangled, are crucial to define, as appropriate and personalized therapeutic strategies will aim at targeting the most significant ones. There are no recommendations so far as to the indications and modalities of the medical treatment of SAPH, which is based upon the opinion of a multidisciplinary team of sarcoidosis, pulmonary hypertension and sometimes lung transplant experts.

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Section: Discussionmentioning

confidence: 82%

“…Finally, a recent study has addressed the question of risk factors for hospitalization in patients with SAPH undergoing LTx evaluation [105], as it has been addressed in group 1 PH [106,107]. It showed that 60% of sarcoid patients with PH were hospitalized at least once for respiratory failure before LTx or death.…”

Section: Discussionmentioning

confidence: 99%