Predictors of hospitalization in patients with systemic lupus erythematosus: a 10-year cohort study

Assunção, H.; Rodrigues, Marília; Prata, Ana Rita; Luís, Mariana; Silva, José António Pereira da; Inês, Luís

doi:10.1007/s10067-022-06251-7

Cited by 4 publications

(4 citation statements)

References 37 publications

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“…Previous studies have already noted the increased risk of admission with SLE disease activity and steroid dosage, and serological marker and organ damage were not evaluated in our study. 4,5,8,9 We did not found that the use of hydroxychloroquine was associated with a lower risk for hospitalization, and we were unable to analyze whether the use of cyclophosphamide was associated with an increased risk of hospitalization because only three patients used this medication in our cohort. 8,9 We also found that several novel risk factors, including a lower educational level, smoking, underweight, and alcohol, were important for prediction of hospitalization.…”

Section: Discussionmentioning

confidence: 81%

“…The recall period for disease activity is the previous 10 days. 8 Disease activity was categorized as mild (SLEDAI-2K ≤6), moderate (6 < SLEDAI-2K ≤12), or high (SLEDAI-2K >12). 15 The recently developed SLE-DAS consists of major disease manifestations in the 24-item SLEDAI-2K, except for pyuria, hematuria, urinary casts, and fever, and SLE-DAS modified and added some additional items, including hemolytic anemia, cardiopulmonary, and gastrointestinal involvement.…”

Section: Measurement Of Disease Activitymentioning

confidence: 99%

“…3 Various parameters, including medication, clinical manifestation of SLE, serology, organ damage, and most importantly, SLE disease activity, have been associated with an increased risk of hospital admissions. [4][5][6][7][8][9] Traditionally, the Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) has been used to define the disease activity of SLE for more than 20 years. 10 Recently, Jesus et al developed a new SLE disease measurement tool called the Systemic Lupus Erythematosus Disease Activity Score (SLE-DAS), which is based on the parameters accessed by SLEDAI-2K with additional clinical manifestations of SLE and several changes, including arthritis, proteinuria, thrombocytopenia, and leukopenia, from categorical ratings to continuous measurements.…”

Section: Introductionmentioning

confidence: 99%

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Increased frequency of hospital admissions with active systemic lupus erythematosus disease activity defined by two different disease activity indices: A cohort study

Wang

Koo

Hsu

et al. 2023

Lupus

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The objective of this cohort study was to evaluate the association between the frequency of hospital admissions and disease activity, as defined by two different disease activity measurements: the Systemic Lupus Erythematosus Disease Activity Score (SLE-DAS) and the Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K), in adult patients with systemic lupus erythematosus (SLEs). Patients with SLE were recruited from the rheumatology outpatient department of a regional hospital in southern Taiwan. SLE-DAS and SLEDAI-2K were used to define SLE disease activity and the cause of hospital admissions was identified by a rheumatologist based on medical records. A generalized linear model (GLM) with gamma distribution and log-linked function was used to analyze variables associated with the frequency of admission. The mean frequency of hospitalization was 0.34 times per year for all-cause and 0.21 times per year for SLE-related admission. Multivariate GLM analysis showed that moderate/severe SLE disease activity defined by SLE-DAS was associated with an increased frequency of all-cause and SLE-related hospital admissions while adjusting for other covariates. Moderate/severe SLE disease activity defined by SLEDAI-2K was only significantly associated with an increased frequency of all-cause hospitalization. When steroid dosage was included in the model, moderate/severe SLE disease activity defined by the SLE-DAS remained significantly associated with SLE-related hospital admissions ( p = 0.032). In conclusion, disease activity defined by the SLE-DAS, but not SLEDAI-2K was associated with an increased frequency of SLE-related hospitalization. Steroid dosage, a lower educational level, and smoking were associated with an increased frequency of hospital admissions, whereas underweight and alcohol use were associated with a decreased frequency of hospital admissions. Rheumatologists should promptly control SLE disease activity of their patients, provide them with adequate health education, and maintain steroid doses to as low as possible to reduce the risk of hospital admissions.

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Section: Discussionmentioning

confidence: 81%

Section: Measurement Of Disease Activitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Increased frequency of hospital admissions with active systemic lupus erythematosus disease activity defined by two different disease activity indices: A cohort study

Wang

Koo

Hsu

et al. 2023

Lupus

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“…Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that affects several organs in the body and is more common among females [1]. Genetically predisposed individuals seem to develop loss of T-cell tolerance to self-antigens [2], resulting in increased production of autoantibodies and an imbalance between Th17 and regulatory T-cells [3,4].…”

Section: Introductionmentioning

confidence: 99%

Blood levels of brain-derived neurotrophic factor (BDNF) in systemic lupus erythematous (SLE): a systematic review and meta-analysis

et al. 2023

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Objectives BDNF has been implicated in the pathophysiology of systemic lupus erythematosus (SLE), especially its neuropsychiatric symptoms. The purpose of this study was to investigate the profile of blood BDNF levels in patients with SLE. Methods We searched PubMed, EMBASE, and the Cochrane Library for papers that compared BDNF levels in SLE patients and healthy controls (HCs). The Newcastle–Ottawa scale was used to assess the quality of the included publications, and statistical analyses were carried out using R 4.0.4. Results The final analysis included eight studies totaling 323 healthy controls and 658 SLE patients. Meta-analysis did not show statistically significant differences in blood BDNF concentrations in SLE patients compared to HCs (SMD 0.08, 95% CI [ − 1.15; 1.32], P value = 0.89). After removing outliers, there was no significant change in the results: SMD -0.3868 (95% CI [ − 1.17; 0.39], P value = 0.33. Univariate meta-regression analysis revealed that sample size, number of males, NOS score, and mean age of the SLE participants accounted for the heterogeneity of the studies (R2 were 26.89%, 16.53%, 18.8%, and 49.96%, respectively). Conclusion In conclusion, our meta-analysis found no significant association between blood BDNF levels and SLE. The potential role and relevance of BDNF in SLE need to be further examined in higher quality studies.

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Hospitalization and outcome of systemic lupus erythematosus patients admitted to the Rheumatology ward of Kasr Al-Ainy University Hospital

Kotb

Khalad

Moghazy

2023

The Egyptian Rheumatologist

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Predictors of hospitalization in patients with systemic lupus erythematosus: a 10-year cohort study

Cited by 4 publications

References 37 publications

Increased frequency of hospital admissions with active systemic lupus erythematosus disease activity defined by two different disease activity indices: A cohort study

Increased frequency of hospital admissions with active systemic lupus erythematosus disease activity defined by two different disease activity indices: A cohort study

Blood levels of brain-derived neurotrophic factor (BDNF) in systemic lupus erythematous (SLE): a systematic review and meta-analysis

Hospitalization and outcome of systemic lupus erythematosus patients admitted to the Rheumatology ward of Kasr Al-Ainy University Hospital

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