The study examined demographic factors as antecedents towards turnover intentions for secondary school teachers in Mbarara District. The study was conducted by collecting quantitative data from over 600 teachers in 64 secondary schools in Mbarara District. The data collected were analysed for variation of turnover intentions with demographic factors including age, gender, work experience, religious affiliation and teacher qualifications. Kruskal Wallis and t-tests were conducted to examine turnover intention scores with the demographic factors of teachers. Study results showed that demographic factors are actually antecedents of turnover intentions among secondary school teachers in Mbarara District. It is thus suggested that schools should plan to accommodate the different demographic factors of their staff to minimize turnover intentions among teachers. Additionally, schools should constructively manage professional growth and development of teachers without increasing turnover. Increasing job responsibility for teachers who attain better qualifications and performance-based incentives can equally reduce attrition and turnover intentions among secondary school teachers.