Predictors of IVF/ICSI success following treatment of endometriosis as the cause of primary infertility

Bila, Jovan; Vidaković, S; Radjenović, Svetlana Spremović; Dokić, Milan; Surlan, Lela; Sparić, Radmila

doi:10.5603/gp.a2018.0042

Cited by 6 publications

(9 citation statements)

References 31 publications

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“…In addition, Billa et al 2018 reported a higher pregnancy rate in the surgery + ART group who received 3‐6 months of repressive therapies according to the stage of endometriosis rather than the surgery group who did not receive repressive therapy before ART (44% vs. 21%). They also had better results than in the ART alone group . This point may have not been considered in the studies evaluated in this meta‐analysis.…”

Section: Discussionmentioning

confidence: 94%

“…All data about the authors, places and period of research, studies and diagnostic methods, treatment methods, and outcomes of research are given in Table …”

Section: Resultsmentioning

confidence: 99%

“…In terms of severity of endometriosis, 333 patients were in stage III or stage IV based on the ASRM classification that was mentioned in only four articles …”

Section: Resultsmentioning

confidence: 99%

“…The results did not show any significant differences among the three groups, but surgery and aspiration of the cyst before starting ART procedures seemed to increase the fertilization rate without any difference in duration of stimulation of ovaries or in required dosage of hormonal drugs during the ART procedure. Only one study was found regarding postsurgical treatment with GNRH‐agonist drugs, especially in moderate‐to‐severe endometriotic and symptomatic women, and their effects on pregnancy rate …”

Section: Resultsmentioning

confidence: 99%

“…Only three articles mentioned the duration of infertility in the absence of associated infertility factors; Billa et al, and Alborzi et al mentioned a duration of more than one year, and Pubuccu et al reported a mean period of infertility of 5 years. Moreover, they had better outcomes of pregnancy in the group with a shorter infertility duration.…”

Section: Resultsmentioning

confidence: 99%

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The success of various endometrioma treatments in infertility: A systematic review and meta‐analysis of prospective studies

Alborzi

Sorouri

Askari

et al. 2019

Reprod Medicine & Biology

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Background Endometriosis is seen in 0.5%‐5% of fertile and 25%‐40% of infertile women. To investigate this conflict between gynecologists that ovarian endometriomas should be removed or not before making any decision about pregnancy among infertile women, the authors decided to carry out a systematic review and meta‐analysis to compare the effect of various available therapeutic methods and notice the impact of these options on women's pregnancy rate. Methods This review is based on PRISMA recommendations with an electronic search using the following databases: PubMed, Scopus, Google scholar, etc, from 2000 to 2018, in the English language. The studies compare pregnancy rate based on four different treatment types of OMAs between infertile women: (surgery + ART, surgery + spontaneous pregnancy, aspiration ± sclerotherapy + ART, and ART alone). Main findings At least eight prospective studies were included, in which 553 infertile women were compared in terms of treatment methods of OMAs before trying to become pregnant. Conclusion Treatments are usually based on the patient's clinical condition and must be individual, with the purpose of relieving pain, improving fertility, or both. The authors do not have not any significant difference between our four groups of study; however, the success of surgical procedure compared to other methods was higher and the success of ART alone was the least.

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Section: Discussionmentioning

confidence: 94%

“…All data about the authors, places and period of research, studies and diagnostic methods, treatment methods, and outcomes of research are given in Table …”

Section: Resultsmentioning

confidence: 99%

“…In terms of severity of endometriosis, 333 patients were in stage III or stage IV based on the ASRM classification that was mentioned in only four articles …”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

The success of various endometrioma treatments in infertility: A systematic review and meta‐analysis of prospective studies

Alborzi

Sorouri

Askari

et al. 2019

Reprod Medicine & Biology

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IVF Outcome in Patients with Different Stages of Endometriosis: Can AMH Be a Predictor?

Marwaha¹

2022

FandR

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Background and Objectives: The role of Anti Mullerian Hormone (AMH) in determining the outcome of in vitro fertilization (IVF) in endometriosis has been controversial. This study was conducted to assess whether AMH can predict poor response in endometriosis patients undergoing IVF and to compare the IVF outcomes among the different stages of endometriosis. Methodology: A retrospective study was conducted among 90 endometriosis patients undergoing IVF using the flexible antagonist protocol from January 2016 to December 2018 at DY Patil Medical College, Navi Mumbai. Serum AMH levels were obtained from different patients, primary outcome being clinical pregnancy rate (CPR) while the secondary outcome included the number of oocytes retrieved, number of mature oocytes obtained, fertilization rates (FR), and number of good quality embryos formed. Data was analyzed with SPSS 16.0. Mann-Whitney U and chi-square tests were used to compare the outcomes of IVF with AMH level in different stages of endometriosis. Receiver Operator Characteristic (ROC) curves were plotted to know the predictive ability of AMH by determining the area under the curve (AUC), [Formula: see text] value < 0.05 was considered significant for all statistical tests. Results: AUC was found to be significant for AMH in detecting poor response among those with late staged endometriosis but with poor accuracy (AUC = 0.65, [Formula: see text] = 0.02[Formula: see text]). Considering a median AMH level of 1.24 ng/mL with sensitivity and specificity of > 60%, the primary and secondary outcomes were significantly higher among those with median AMH levels of more than 1.24 ng/mL compared to those with the median [Formula: see text] 1.24 ng/mL. The significance, however, was mainly found in the late stages of endometriosis ([Formula: see text] < 0.05). Fertilization rates, good quality embryos, and CPR did not vary with AMH levels among those with early stages of endometriosis ([Formula: see text] > 0.05). The outcomes of IVF did not vary significantly across the different stages of endometriosis except for good quality embryos which were formed in patients with early staged endometriosis ([Formula: see text] < 0.05). Conclusion: AMH levels may be a predictor of nonconception with poor accuracy in late stages of endometriosis (III/IV), while good quality embryos were obtained in patients with early stages of endometriosis.

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Ендометріоз-Асоційоване Безпліддя: Нові Підходи Діагностики Та Лікування

Хміль¹,

Візняк²,

Хміль³

et al. 2023

ЗКЕМ

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РЕЗЮМЕ. Eндомeтріоз – однe з нaйпоширeніших зaхворювaнь жіночої рeпродуктивної систeми. Нeзвaжaючи нa понад столітній пeріод з момeнту появи пeрших повідомлeнь про цю проблeму, дeякі aспeкти eтіології, пaтогeнeзу, клініки, діaгностики, лікувaння тa профілaктики цьoго зaхворювaння зaлишaються прeдмeтом нaукових дoсліджeнь. Мета – aнaліз впливу eндомeтріозу нa фeртильність тa використaння допoміжних рeпрoдуктивних тeхнологій у жінок, які хворіють нa дaне зaхворювaння. Матеріал і методи. Було проaнaлізовaно 42 джерела сучaсної наукової літератури, з яких 35 – іноземні. Для цього застосували бібліосемантичний метод. Результати. Eндомeтріоз зaлишaється причинoю вeликої кількості діaгностичних помилок, незвaжaючи нa використaння сучaсних мeтодів обстeжeння. На сьогодні нe існує жодних відомих спосoбів профілaктики eндомeтріозу. Підвищeння обізнaності, рaння підозрa, а тaкож рaння діaгностикa тa лікувaння можуть сповільнити aбо зупинити прогрeсувaння зaхворювaння, оскільки eндомeтріоз чaсто можe мaти симптоми, що імітують інші стaни, чeрeз що діaгностикa є усклaднeною. Бeзліч схeм тa мeтодик лікувaння хворих нa eндомeтріоз при бeзплідді, у тому числі нa eтaпі підготовки до прогрaми допоміжних рeпродуктивних тeхнологій (ДРТ), викликaють дискусії. Висновки. Проблeмa лікування хворих нa eндомeтріоз є склaдною і до кінця нe вирішeною нa сьогоднішній день. Для кожної конкрeтної пaцієнтки слід розробити індивідуaльну схeму обстeжeння і лікувaння. Нe викликає сумніву, що бeзпeрeрвні досліджeння мeхaнізмів пaтогeнeзу, імунологічних тa гeнeтичних основ зaхворювaння, розробкa нових мeтодик хірургічного лікувaння, схeм корeкції клінічних проявів eндомeтріозу тa оптимізaція профілaктичних зaходів покрaщaть eфeктивність тeрaпії тa підвищaть якiсть життя пaцієнток.

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Predictors of IVF/ICSI success following treatment of endometriosis as the cause of primary infertility

Abstract: Therapy for endometriosis, AMH and P4 levels appeared to be predictors for the successful IVF/ICSI outcome and the use of long protocol with agonists could be advised in these cycles.

Cited by 6 publications

References 31 publications

The success of various endometrioma treatments in infertility: A systematic review and meta‐analysis of prospective studies

The success of various endometrioma treatments in infertility: A systematic review and meta‐analysis of prospective studies

IVF Outcome in Patients with Different Stages of Endometriosis: Can AMH Be a Predictor?

Ендометріоз-Асоційоване Безпліддя: Нові Підходи Діагностики Та Лікування

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