Predictors of Liver Cancer: a Review

Abstract

The present paper reviews current publications of Russian and foreign authors addressing the issues of liver pathology and associated consequences. Primary liver cancer is a malignant tumor originated from hepatocytes and epithelium of the biliary duct. It differs from other liver pathologies by rapid progression and low life expectancy of patients. The morphology of cancer and its carcinogenesis is particularly considered. The paper describes the carcinogenesis of liver cancer in detail. Numerous scientific papers consider liver cancer as a global health issue due to the late diagnosis and, consequently, the limited treatment options for patients with this disease. The analysis of recent publications revealed that the incidence of this pathology tends to increase worldwide. According to the available data provided by different experts who study cancer globally, about 906 thousand new cases of liver cancer are registered annually and the number of patients is expected to exceed 1.4 million by 2040. In the conclusion, the present paper briefly observes the reasons of the late diagnosis of liver cancer and its consequences.