Predictors of local adverse effects caused by topical tretinoin cream 0·1% in the Veterans Affairs Topical Tretinoin Chemoprevention trial

Pomerantz, Hyemin; Weinstock, Martin A.

doi:10.1111/bjd.12987

Cited by 4 publications

(3 citation statements)

References 13 publications

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“…Predicting which patients will be susceptible to retinoid irritation poses a clinical challenge [ 57 ]. A 2014 study designed to evaluate predictors of irritation with tretinoin cream ( n = 324) reported 61% of subjects had local adverse effects.…”

Section: Introductionmentioning

confidence: 99%

“…A 2014 study designed to evaluate predictors of irritation with tretinoin cream ( n = 324) reported 61% of subjects had local adverse effects. Increased risk for side effects was associated with the use of other topical medications (OR 1.88, 95% CI 1.15–3.08) [ 57 ]. Thus, when utilizing topical tretinoin as part of a combination regimen—as is recommended for most patients with acne—it may be prudent to utilize one or more of the strategies listed in Table 1 .…”

Section: Introductionmentioning

confidence: 99%

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Why Topical Retinoids Are Mainstay of Therapy for Acne

Leyden

Stein-Gold

Weiss

2017

Dermatol Ther (Heidelb)

122

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Acne-focused dermatology expert groups have consistently recommended that most patients with acne be treated with a combination of topical retinoid and antimicrobial therapy. This is based on clinical data as well as evidence that these drug classes have different and complementary mechanisms of action that target multiple aspects of acne’s complex pathophysiology. Recent evidence-based guidelines for acne, including those from the American Academy of Dermatology (AAD) and the European Dermatology Forum (EDF), have agreed that retinoids have an essential role in this widespread disease. The AAD states “retinoids are the core of topical therapy for acne because they are comedolytic, resolve the precursor microcomedone lesion, and are anti-inflammatory;” further, they “allow for maintenance of clearance.” Despite uniform recommendation for use of topical retinoids, a recent study of prescribing practices from 2012 to 2014 indicated that dermatologists prescribed retinoids just 58.8% of the time while non-dermatologists prescribed them for only 32.4% of cases. In this article, we review the reasons supporting retinoids as the mainstay of acne therapy and discuss some of the perceived barriers that may be limiting use of this important drug class. Further, we discuss how and when titrating retinoid concentrations may be utilized in clinical practice. Funding: Galderma International.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Why Topical Retinoids Are Mainstay of Therapy for Acne

Leyden

Stein-Gold

Weiss

2017

Dermatol Ther (Heidelb)

122

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“…Both excess and shortage of ATRA were shown to have pathophysiological consequences and rather tight maintenance of ATRA levels is necessary both in development and adult life in order to prevent disease manifestation [ 2 ]. Apart from its well described role as a teratogen, variety of side-effects associated with ATRA therapy in postnatal stages of life have been described both for topical [ 3 ] and systemic administration [ 4 ]. Serum concentrations of lipids [ 5 , 6 ], glucose tolerance or bone metabolism [ 7 ] are among the systems most frequently affected in adverse reactions to ATRA administration.…”

Section: Introductionmentioning

confidence: 99%

Pharmacogenomic analysis of retinoic-acid induced dyslipidemia in congenic rat model

et al. 2014

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BackgroundAll-trans retinoic acid (ATRA, tretinoin) is a vitamin A derivative commonly used in the treatment of diverse conditions ranging from cancer to acne. In a fraction of predisposed individuals, the administration of ATRA is accompanied by variety of adverse metabolic effects, particularly by the induction of hyperlipidemia. We have previously derived a minimal congenic SHR.PD-(D8Rat42-D8Arb23)/Cub (SHR-Lx) strain sensitive to ATRA-induced increase of triacylglycerols and cholesterol under condition of high-sucrose diet. SHR-Lx differs only by 7 genes of polydactylous rat (PD/Cub) origin from its spontaneously hypertensive rat (SHR) progenitor strain.MethodsAdult male rats of SHR and SHR-Lx strains were fed standard diet (STD) and experimental groups were subsequently treated with ATRA (15 mg/kg) via oral gavage for 16 days, while still on STD. We contrasted the metabolic profiles (including free fatty acids, triacylglycerols (TG) and cholesterol (C) in 20 lipoprotein fractions) between SHR and SHR-Lx under conditions of standard diet and standard diet + ATRA. We performed transcriptomic analysis of muscle tissue (m. soleus) in all groups using Affymetrix GeneChip Rat Gene 2.0 ST Arrays followed by Ingenuity Pathway Analysis and real-time PCR validation.ResultsIn response to ATRA, SHR-Lx reacted with substantially greater rise in TG and C concentrations throughout the lipoprotein spectrum (two-way ANOVA strain * RA interaction significant for C content in chylomicrons (CM), VLDL and LDL as well as total, CM and HDL-TG).ConclusionsAccording to our modeling of metabolic and signalization pathways using differentially expressed genes we have identified a network with major nodes (including Sirt3, Il1b, Cpt1b and Pparg) likely to underlie the observed strain specific response to ATRA.Electronic supplementary materialThe online version of this article (doi:10.1186/1476-511X-13-172) contains supplementary material, which is available to authorized users.

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Interventions for preventing keratinocyte cancer in high-risk groups not receiving immunosuppressive therapy

Morales‐Sánchez¹,

Peralta‐Pedrero²,

Cruz³

et al. 2016

Cochrane Database of Systematic Reviews

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Predictors of local adverse effects caused by topical tretinoin cream 0·1% in the Veterans Affairs Topical Tretinoin Chemoprevention trial

Abstract: In this study population, the common indications of topical tretinoin treatment were associated with lower risks of adverse effects. The concurrent use of other topical medications may worsen irritation caused by tretinoin.

Cited by 4 publications

References 13 publications

Why Topical Retinoids Are Mainstay of Therapy for Acne

Why Topical Retinoids Are Mainstay of Therapy for Acne

Pharmacogenomic analysis of retinoic-acid induced dyslipidemia in congenic rat model

Interventions for preventing keratinocyte cancer in high-risk groups not receiving immunosuppressive therapy

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