Predictors of locoregional recurrence in early stage buccal cancer with pathologically clear surgical margins and negative neck

Zaman, Shakeel Uz; Aqil, Shakil; Sulaiman, Mohammad Ahsan

doi:10.1016/j.otorri.2017.09.003

Cited by 4 publications

(2 citation statements)

References 18 publications

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“…However, this chance is low since most recurrences occurred within the first year. Furthermore, our 0% local recurrence rate for tumor‐free margins of ≥5.0 mm is low compared to the literature, where rates of 6%–52% are reported 20,24,33,39,45 . However, local recurrence in case of field cancerization is often not clearly defined, and new primaries could therefore have been reported as local recurrences in these studies.…”

Section: Discussioncontrasting

confidence: 62%

“…Furthermore, our 0% local recurrence rate for tumor-free margins of ≥5.0 mm is low compared to the literature, where rates of 6%-52% are reported. 20,24,33,39,45 However, local recurrence in case of field cancerization is often not clearly defined, and new primaries could therefore have been reported as local recurrences in these studies. The aspect of dysplasia in the resection margins, the worst pattern of invasion, and the effect of adjuvant therapy on quality of life were not addressed in this study and are suggested for future research.…”

Section: Perspectivementioning

confidence: 93%

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A closer look at the resection margins of buccal mucosa cancer: Their influence on local recurrence free survival

et al. 2023

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Background: The adequate surgical margin for local control of buccal mucosa squamous cell carcinoma (BMSCC) is under debate. This study investigates surgical margins and other factors associated with local recurrence free survival (LRFS) in a large cohort of BMSCC patients.Methods: Multiple factors were evaluated retrospectively in 97 patients with BMSCC. Cox-regression and Kaplan-Meier curves were used for analysis.Results: The local recurrence rate was 23%. The tumor-free margin was <5.0 mm in 89% of the patients and the deep margin was significantly more often inadequate. Multivariate analysis associated pT3-classification, former smokers, tumor-free margin status, and postoperative (chemo)radiation (PO (ch)RT) with local recurrence. Re-resections did not improve LRFS in patients with <5.0 mm tumor-free margins.Conclusions: Adequate tumor-free margins are pivotal for LRFS of BMSCC. PO(ch)RT, not re-resection, can improve LRFS in patients with <5.0 mm tumor-free margins.

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Section: Discussioncontrasting

confidence: 62%

Section: Perspectivementioning

confidence: 93%

A closer look at the resection margins of buccal mucosa cancer: Their influence on local recurrence free survival

et al. 2023

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Cumulative suppressive index as a predictor of relapse free survival and overall survival in Human Papilloma Virus‐negative oral squamous cell carcinomas with negative resection margins

et al. 2020

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Background: This study aimed to analyze margin status and the impact of the immune elements on recurrence in patients with oral squamous cell carcinoma (OSCC), employing a prognostic biomarker, cumulative suppressive index (CSI), which reflects FoxP3+, PD-L1+, and CD8+ cell spatial relationships in the tumor microenvironment. Methods: Cox proportional hazards regression was used to evaluate the interactive effect of the margin by CSI discrepancy (high, 3-4 vs low, 0-2) on recurrence free survival (RFS) and overall survival (OS) in 119 patients with stage I to IVA OSCC. Results: In cases with negative margins, multivariable analysis showed high CSI was significantly associated with worse RFS (HR = 2.59, 95% CI [1.03, 6.49], P = .04) and OS (HR = 5.49, 95% CI [1.48, 20.35], P = .01) compared to low CSI. However, high CSI was not significantly associated with recurrence in cases with positive margins.

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Clinicopathologic predictors of survival in buccal squamous cell carcinoma

Marinelli

Chatzopoulos

Marinelli

et al. 2020

J Oral Pathology Medicine

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Background: Buccal squamous cell carcinoma (SCC) is a locoregionally aggressive malignancy, representing a small subset of oral cancers in North America. We investigated the prognostic value of several clinicopathologic factors in a cohort of patients diagnosed with buccal SCC. Methods: Between years 1992 and 2017, 52 patients were diagnosed with conventional buccal SCC. Archival surgical pathology material was retrospectively reviewed for reportable findings according to the latest reporting guidelines published by the College of American Pathologists. Clinical data were obtained through chart review. Results: The majority of patients were of older age, current or past smokers, and without specific gender predilection. Most presented at a clinically advanced stage and were treated with surgery alone, or surgery followed by adjuvant radiotherapy. The tumor recurred in about 40% of patients, and almost half of the patients died from the disease by the end of the follow-up period. The worst pattern of invasion (WPOI) was associated with greater depth of invasion (DOI) (P = .031) and perineural invasion (P < .001). In univariate analyses, older age (P = .004), positive nodal status (P = .047), lymphovascular invasion (P = .012), perineural invasion (P = .05), and WPOI-5 (P = .015) were adverse predictors of 5-year overall survival (OS). In multivariate analysis, older age (P = .011), WPOI-5 (P < .001), and perineural invasion (P = .001) remained statistically significant independent prognosticators of worse 5-year OS. Conclusions: Older age, WPOI-5, and perineural invasion are significant prognosticators of worse OS. WPOI is associated with DOI, a finding which may have important implications for the pathogenesis and biologic behavior of the disease.

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Predictors of locoregional recurrence in early stage buccal cancer with pathologically clear surgical margins and negative neck

Cited by 4 publications

References 18 publications

A closer look at the resection margins of buccal mucosa cancer: Their influence on local recurrence free survival

A closer look at the resection margins of buccal mucosa cancer: Their influence on local recurrence free survival

Cumulative suppressive index as a predictor of relapse free survival and overall survival in Human Papilloma Virus‐negative oral squamous cell carcinomas with negative resection margins

Clinicopathologic predictors of survival in buccal squamous cell carcinoma

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